Adipocytes affect castration-resistant prostate cancer cells to develop the resistance to cytotoxic action of NK cells with alterations of PD-L1/NKG2D ligand levels in tumor cells

Among Active Surveillance Candidates does Obesity Influence Tumor Aggressiveness and/or Location?

(2017) Alexis R. Freedland et al.   JOURNAL OF UROLOGY

Radiation alters PD-L1/NKG2D ligand levels in lung cancer cells and leads to immune escape from NK cell cytotoxicity via IL-6-MEK/Erk signaling pathway

(2017) Ming Jing Shen et al.   Oncotarget

Enhancing NK cell-mediated cytotoxicity to cisplatin-resistant lung cancer cells via MEK/Erk signaling inhibition

(2017) Li Yang et al.   Scientific Reports

Cisplatin enhances NK cells immunotherapy efficacy to suppress HCC progression via altering the androgen receptor (AR)-ULBP2 signals

(2016) Liang Shi et al.   CANCER LETTERS

Inherent and Tumor-Driven Immune Tolerance in the Prostate Microenvironment Impairs Natural Killer Cell Antitumor Activity

(2016) Christine Pasero et al.   CANCER RESEARCH

Influence of adipocytokines in periprostatic adipose tissue on prostate cancer aggressiveness

(2016) Qiang Zhang et al.   CYTOKINE

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: a single-arm, multicentre, phase 2 trial

(2016) Jonathan E Rosenberg et al.   LANCET

Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity

(2016) Victor Laurent et al.   Nature Communications

Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer

(2016) Valsamo Anagnostou et al.   Cancer Discovery

Early evidence of anti-PD-1 activity in enzalutamide-resistant prostate cancer

(2016) Julie N. Graff et al.   Oncotarget

Serum Amyloid A3 Gene Expression in Adipocytes is an Indicator of the Interaction with Macrophages

(2016) Yohei Sanada et al.   Scientific Reports

Control of PD-L1 Expression by Oncogenic Activation of the AKT–mTOR Pathway in Non–Small Cell Lung Cancer

(2015) Kristin J. Lastwika et al.   CANCER RESEARCH

Immune checkpoint regulator PD-L1 expression on tumor cells by contacting CD11b positive bone marrow derived stromal cells

(2015) Hyangsoon Noh et al.   Cell Communication and Signaling

Interaction between human mature adipocytes and lymphocytes induces T-cell proliferation

(2015) Antonella Poloni et al.   CYTOTHERAPY

Re: Ipilimumab versus Placebo after Radiotherapy in Patients with Metastatic Castration-Resistant Prostate Cancer that had Progressed after Docetaxel Chemotherapy (CA184-043): A Multicentre, Randomised, Double-Blind, Phase 3 Trial

(2015) Samir S. Taneja   JOURNAL OF UROLOGY

The Clinical Relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 Network in Chemoresistant Non-small-cell Lung Cancer

(2015) Yu Fujita et al.   MOLECULAR THERAPY

Nivolumab versus Docetaxel in Advanced Nonsquamous Non–Small-Cell Lung Cancer

(2015) Hossein Borghaei et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

(2015) Robert J. Motzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-β1/Smad/MMP9 signals

(2015) Hongjun Xie et al.   Oncotarget

Highly effective NK cells are associated with good prognosis in patients with metastatic prostate cancer

(2015) Christine Pasero et al.   Oncotarget

Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression

(2015) Roberto Bellucci et al.   OncoImmunology

3T3-L1 adipocytes display phenotypic characteristics of multiple adipocyte lineages

(2015) Shona Morrison et al.   Adipocyte

Inducible but Not Constitutive Expression of PD-L1 in Human Melanoma Cells Is Dependent on Activation of NF-κB

(2015) Kavitha Gowrishankar et al.   PLoS One

Loss of Lkb1 and Pten Leads to Lung Squamous Cell Carcinoma with Elevated PD-L1 Expression

(2014) Chunxiao Xu et al.   CANCER CELL

Prolactin is a major inhibitor of hepatic Leptin A synthesis and secretion: Studies utilizing a homologous Leptin A ELISA in the tilapia

(2014) Jonathan D. Douros et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial

(2014) Eugene D Kwon et al.   LANCET ONCOLOGY

Adipokines – removing road blocks to obesity and diabetes therapy

(2014) Matthias Blüher   Molecular Metabolism

Destructive impact of t-lymphocytes, NK and mast cells on basal cell layers: implications for tumor invasion

(2013) Hongyan Yuan et al.   BMC CANCER

Periprostatic Adipose Tissue and Prostate Cancer Progression: New Insights into the Tumor Microenvironment

(2013) Paul Toren et al.   Clinical Genitourinary Cancer

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease

(2013) Annika Mehlem et al.   Nature Protocols

Importance of NKG2D-NKG2D ligands interaction for cytolytic activity of natural killer cell

(2012) Deok Sung Bae et al.   CELLULAR IMMUNOLOGY

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Human Primary Adipocytes Exhibit Immune Cell Function: Adipocytes Prime Inflammation Independent of Macrophages

(2011) Kees Meijer et al.   PLoS One

A Simple Protocol for Using a LDH-Based Cytotoxicity Assay to Assess the Effects of Death and Growth Inhibition at the Same Time

(2011) Shilo M. Smith et al.   PLoS One

The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody

(2010) D. M. Benson et al.   BLOOD

Associations between adipokines and obesity-related cancer

(2010) Gilberto Paz-Filho   Frontiers in Bioscience-Landmark

High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation

(2010) Chuan-Yong Mu et al.   MEDICAL ONCOLOGY

B7-H1 expression is regulated by MEK/ERK signaling pathway in anaplastic large cell lymphoma and Hodgkin lymphoma

(2009) Ryo Yamamoto et al.   CANCER SCIENCE

Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients

(2009) Philippe O. Gannon et al.   JOURNAL OF IMMUNOLOGICAL METHODS

NKG2D ligands in tumor immunity

(2008) N Nausch et al.   ONCOGENE

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

(2008) M. Marzec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NKG2D ligands: key targets of the immune response

(2008) Segundo González et al.   TRENDS IN IMMUNOLOGY