Causes and Consequences of A Glutamine Induced Normoxic HIF1 Activity for the Tumor Metabolism

Pharmacologic Targeting of Hypoxia-Inducible Factors

(2019) Gregg L. Semenza   Annual Review of Pharmacology and Toxicology

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

(2019) Ayako Nagao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

L-ascorbic acid: A true substrate for HIF prolyl hydroxylase?

(2018) Andrey I. Osipyants et al.   BIOCHIMIE

Endocytotic uptake of HPMA-based polymers by different cancer cells: impact of extracellular acidosis and hypoxia

(2017) Daniel Gündel et al.   International Journal of Nanomedicine

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Nucleus accumbens-associated protein-1 promotes glycolysis and survival of hypoxic tumor cells via the HDAC4-HIF-1α axis

(2017) Y Zhang et al.   ONCOGENE

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival

(2016) Steve Stegen et al.   Cell Metabolism

The MCT4 Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer

(2016) S. Y. C. Choi et al.   CLINICAL CANCER RESEARCH

Normoxic accumulation of HIF1α is associated with glutaminolysis

(2016) Matthias Kappler et al.   Clinical Oral Investigations

Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma

(2016) Alexander W. Eckert et al.   Journal of Translational Medicine

Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials

(2016) Peter M Rothwell et al.   LANCET

Downregulation of acetyl-CoA synthetase 2 is a metabolic hallmark of tumor progression and aggressiveness in colorectal carcinoma

(2016) Jeong Mo Bae et al.   MODERN PATHOLOGY

A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome

(2016) Michael H. Tatham et al.   MOLECULAR & CELLULAR PROTEOMICS

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling

(2016) Lili Guo et al.   TUMOR BIOLOGY

Hypoxia regulates global membrane protein endocytosis through caveolin-1 in cancer cells

(2016) E. Bourseau-Guilmain et al.   Nature Communications

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer

(2016) Oscar Aguilera et al.   Oncotarget

In vivo genetic dissection of tumor growth and the Warburg effect

(2016) Cheng-Wei Wang et al.   eLife

Hypoxia-Like Signatures Induced by BCR-ABL Potentially Alter the Glutamine Uptake for Maintaining Oxidative Phosphorylation

(2016) Pallavi Sontakke et al.   PLoS One

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism

(2015) Jianrong Lu et al.   CANCER LETTERS

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells

(2015) Jhudit Pérez-Escuredo et al.   CELL CYCLE

In silico aided thoughts on mitochondrial vitamin C transport

(2015) András Szarka et al.   JOURNAL OF THEORETICAL BIOLOGY

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

Glutaminolysis as a target for cancer therapy

(2015) L Jin et al.   ONCOGENE

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response

(2014) Caroline Kuiper et al.   FREE RADICAL BIOLOGY AND MEDICINE

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer

(2014) Caroline Kuiper et al.   Frontiers in Oncology

Widespread and Enzyme-independentNϵ-Acetylation andNϵ-Succinylation of Proteins in the Chemical Conditions of the Mitochondrial Matrix

(2013) Gregory R. Wagner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

(2013) Ruiting Lin et al.   MOLECULAR CELL

Cavin-3 dictates the balance between ERK and Akt signaling

(2013) Victor J Hernandez et al.   eLife

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Snakemake--a scalable bioinformatics workflow engine

(2012) J. Koster et al.   BIOINFORMATICS

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

(2012) N. Zaidi et al.   CANCER RESEARCH

The real face of HIF1α in the tumor process

(2012) Matthias Kappler et al.   CELL CYCLE

Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials

(2012) Peter M Rothwell et al.   LANCET

Therapeutic targeting of cancer cell metabolism

(2011) Chi V. Dang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Oxygen Sensing, Homeostasis, and Disease

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

(2010) C. V. Dang   CANCER RESEARCH

Nitrogen anabolism underlies the importance of glutaminolysis in proliferating cells

(2010) Meng Meng et al.   CELL CYCLE

Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?

(2010) Chi V. Dang   CELL CYCLE

Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

(2010) Peter M Rothwell et al.   LANCET

Regulation of intermediary metabolism by protein acetylation

(2010) Kun-Liang Guan et al.   TRENDS IN BIOCHEMICAL SCIENCES

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas

(2009) Marie E. Beckner et al.   INTERNATIONAL JOURNAL OF CANCER

Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells

(2009) Olivier Feron   RADIOTHERAPY AND ONCOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Activation of HIF-1α in exponentially growing cells via hypoxic stimulation is independent of the Akt/mTOR pathway

(2008) Frédéric Dayan et al.   JOURNAL OF CELLULAR PHYSIOLOGY