Tetrandrine reduces oxidative stress, apoptosis, and extracellular matrix degradation and improves intervertebral disc degeneration by inducing autophagy

The protective effects of dezocine on interleukin-1β-induced inflammation, oxidative stress and apoptosis of human nucleus pulposus cells and the possible mechanisms

(2022) Fang Zhu et al.   Bioengineered

Genetic Therapy for Intervertebral Disc Degeneration

(2021) Eun Roh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy as a potential therapeutic target in intervertebral disc degeneration

(2021) Chao-yang Gong et al.   LIFE SCIENCES

The enhancement of Tetrandrine to gemcitabine-resistant PANC-1 cytochemical sensitivity involves the promotion of PI3K/Akt/mTOR-mediated apoptosis and AMPK-regulated autophagy

(2021) Jianlin Song et al.   ACTA HISTOCHEMICA

The Mechanism of α2-macroglobulin Against Oxidative Stress and Promoting Cell Proliferation in Intervertebral Disc Degeneration

(2021) Hui Liang et al.   Bioengineered

HO-1 induced autophagy protects against IL-1 β-mediated apoptosis in human nucleus pulposus cells by inhibiting NF-κB

(2020) Luetao Zou et al.   Aging-US

Intervertebral disc and endplate cell characterisation highlights annulus fibrosus cells as the most promising for tissue-specific disc degeneration therapy

(2020) P De Luca et al.   EUROPEAN CELLS & MATERIALS

Crosstalk between oxidative stress-induced apoptotic and autophagic signaling pathways in Zn(II) phthalocyanine photodynamic therapy of melanoma

(2020) Federico Valli et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bone-derived mesenchymal stem cells alleviate compression-induced apoptosis of nucleus pulposus cells by N6 methyladenosine of autophagy

(2020) Gaocai Li et al.   Cell Death & Disease

Tetrandrine sensitizes nasopharyngeal carcinoma cells to irradiation by inducing autophagy and inhibiting MEK/ERK pathway

(2020) Jun Wang et al.   Cancer Medicine

Hypoxia Helps Maintain Nucleus Pulposus Homeostasis by Balancing Autophagy and Apoptosis

(2020) Han-Jun Kim et al.   Oxidative Medicine and Cellular Longevity

Allicin Attenuated Advanced Oxidation Protein Product-Induced Oxidative Stress and Mitochondrial Apoptosis in Human Nucleus Pulposus Cells

(2020) Qian Xiang et al.   Oxidative Medicine and Cellular Longevity

Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway

(2020) Dong Wang et al.   Frontiers in Cell and Developmental Biology

Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling

(2019) Yubo Guo et al.   Evidence-based Complementary and Alternative Medicine

Autophagy-Independent Functions of the Autophagy Machinery

(2019) Lorenzo Galluzzi et al.   CELL

Parkin and Nrf2 prevent oxidative stress-induced apoptosis in intervertebral endplate chondrocytes via inducing mitophagy and anti-oxidant defenses

(2019) Liang Kang et al.   LIFE SCIENCES

Restoration of Autophagic Flux Rescues Oxidative Damage and Mitochondrial Dysfunction to Protect against Intervertebral Disc Degeneration

(2019) Liang Kang et al.   Oxidative Medicine and Cellular Longevity

17β-Estradiol Prevents Extracellular Matrix Degradation by Downregulating MMP3 Expression via PI3K/Akt/FOXO3 Pathway

(2019) Xiao-Wen Gao et al.   SPINE

Intervertebral disc regeneration: From cell therapy to the development of novel bioinspired endogenous repair strategies

(2018) Johann Clouet et al.   ADVANCED DRUG DELIVERY REVIEWS

Tetrandrine attenuates the bone erosion in collagen-induced arthritis rats by inhibiting osteoclastogenesis via spleen tyrosine kinase

(2018) Yugai Jia et al.   FASEB JOURNAL

Spermidine promotes nucleus pulposus autophagy as a protective mechanism against apoptosis and ameliorates disc degeneration

(2018) Zengming Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Curcumin protects against diabetic cardiomyopathy by promoting autophagy and alleviating apoptosis

(2018) Qing Yao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Biomechanics of the human intervertebral disc: A review of testing techniques and results

(2017) N. Newell et al.   Journal of the Mechanical Behavior of Biomedical Materials

Tetrandrine, an Activator of Autophagy, Induces Autophagic Cell Death via PKC-α Inhibition and mTOR-Dependent Mechanisms

(2017) Vincent Kam Wai Wong et al.   Frontiers in Pharmacology

Disc cell senescence in intervertebral disc degeneration: Causes and molecular pathways

(2016) Chencheng Feng et al.   CELL CYCLE

Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase-dependent pathways and associated with beclin-1-induced cell autophagy

(2016) Jin-Cherng Lien et al.   ENVIRONMENTAL TOXICOLOGY

Tetrandrine suppresses articular inflammatory response by inhibiting pro-inflammatory factors via NF-κB inactivation

(2016) Li-Na Gao et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Molecular mechanisms of biological aging in intervertebral discs

(2016) Nam V. Vo et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Advances in biological therapy for nucleus pulposus regeneration

(2016) P. Priyadarshani et al.   OSTEOARTHRITIS AND CARTILAGE

Tetrandrine – A molecule of wide bioactivity

(2016) N. Bhagya et al.   PHYTOCHEMISTRY

MMPs and ADAMTSs in intervertebral disc degeneration

(2015) Wen-Jun Wang et al.   CLINICA CHIMICA ACTA

Recombinant human SIRT1 protects against nutrient deprivation-induced mitochondrial apoptosis through autophagy induction in human intervertebral disc nucleus pulposus cells

(2015) Shingo Miyazaki et al.   ARTHRITIS RESEARCH & THERAPY

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells

(2015) Ting Liu et al.   Oncotarget

Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species

(2015) Haiqing Wang et al.   Cell and Bioscience

SIRT1 protects against apoptosis by promoting autophagy in degenerative human disc nucleus pulposus cells

(2014) Wei Jiang et al.   Scientific Reports

Comparison of biological processes induced in HepG2 cells by tert-butyl hydroperoxide (t-BHP) and hydroperoxide (H2O2): The influence of carvacrol

(2013) Darina Slamenova et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration

(2013) Nam V. Vo et al.   Spine Journal