An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
An Expanded Polyproline Domain Maintains Mutant Huntingtin Soluble in vivo and During Aging
Authors
Keywords
-
Journal
Frontiers in Molecular Neuroscience
Volume 14, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-10-16
DOI
10.3389/fnmol.2021.721749
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- In Silico Analysis of Huntingtin Homologs in Lower Eukaryotes
- (2021) Valentina Brandi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Rethinking protein aggregation and drug discovery in neurodegenerative diseases: Why we need to embrace complexity?
- (2021) Hilal A. Lashuel CURRENT OPINION IN CHEMICAL BIOLOGY
- Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I
- (2020) Alberto Ceccon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Thermodynamics of Huntingtin Aggregation
- (2020) Tam T.M. Phan et al. BIOPHYSICAL JOURNAL
- The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species
- (2020) Jessica Tittelmeier et al. EMBO JOURNAL
- Evidence of the Reduced Abundance of Proline cis Conformation in Protein Poly Proline Tracts
- (2020) Annika Urbanek et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Flanking Regions Determine the Structure of the Poly-Glutamine in Huntingtin through Mechanisms Common among Glutamine-Rich Human Proteins
- (2020) Annika Urbanek et al. STRUCTURE
- Characterization of Amyloid Structures in Aging C. Elegans Using Fluorescence Lifetime Imaging
- (2020) Maria Lucia Pigazzini et al. Jove-Journal of Visualized Experiments
- Huntington’s disease alters human neurodevelopment
- (2020) Monia Barnat et al. SCIENCE
- Exploding the Repeat Length Paradigm while Exploring Amyloid Toxicity in Huntington’s Disease
- (2020) Ronald Wetzel ACCOUNTS OF CHEMICAL RESEARCH
- Physical, Biomechanical, and Optical Characterization of Collagen and Elastin Blend Hydrogels
- (2020) Nelda Vazquez-Portalatin et al. ANNALS OF BIOMEDICAL ENGINEERING
- Novel amyloid-beta pathology C. elegans model reveals distinct neurons as seeds of pathogenicity
- (2020) Christian Gallrein et al. PROGRESS IN NEUROBIOLOGY
- Insights into the Aggregation Mechanism of PolyQ Proteins with Different Glutamine Repeat Lengths
- (2018) Tetyana Yushchenko et al. BIOPHYSICAL JOURNAL
- Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers
- (2018) Ammon E. Posey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length
- (2018) Estella A. Newcombe et al. JOURNAL OF MOLECULAR BIOLOGY
- Molecular and structural architecture of polyQ aggregates in yeast
- (2018) Anselm Gruber et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes
- (2018) P. Conforti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington’s Disease
- (2018) Anne Ast et al. MOLECULAR CELL
- The cryo-electron microscopy structure of huntingtin
- (2018) Qiang Guo et al. NATURE
- Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington's disease
- (2018) Kenneth W. Drombosky et al. NEUROBIOLOGY OF DISEASE
- Regulatory mechanisms of incomplete huntingtin mRNA splicing
- (2018) Andreas Neueder et al. Nature Communications
- The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract
- (2018) Jose M. Bravo-Arredondo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
- (2017) John B. Warner et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective
- (2017) Maria Baias et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington’s disease
- (2017) Mingchen Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation
- (2016) Sophie Vieweg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fluorescence Self-Quenching from Reporter Dyes Informs on the Structural Properties of Amyloid Clusters Formed in Vitro and in Cells
- (2016) WeiYue Chen et al. NANO LETTERS
- The Biology of Huntingtin
- (2016) Frédéric Saudou et al. NEURON
- Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core
- (2016) Cody L. Hoop et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Huntington's Paradox
- (2016) Chiara Zuccato et al. SCIENTIFIC AMERICAN
- OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research
- (2016) Seong Kyu Han et al. Oncotarget
- Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract
- (2016) Koning Shen et al. eLife
- Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer
- (2016) Bankanidhi Sahoo et al. PLoS One
- The Biology of Proteostasis in Aging and Disease
- (2015) Johnathan Labbadia et al. Annual Review of Biochemistry
- Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments
- (2015) J. Kirstein et al. EMBO JOURNAL
- The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington’s disease model
- (2015) Matthew B. Veldman et al. Molecular Neurodegeneration
- N17 Modifies Mutant Huntingtin Nuclear Pathogenesis and Severity of Disease in HD BAC Transgenic Mice
- (2015) Xiaofeng Gu et al. NEURON
- Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease?
- (2015) Kevin W. Tipping et al. TRENDS IN BIOCHEMICAL SCIENCES
- Detection of ubiquitinated huntingtin species in intracellular aggregates
- (2015) Katrin Juenemann et al. Frontiers in Molecular Neuroscience
- Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?
- (2014) Guylaine Hoffner et al. MOLECULAR NEUROBIOLOGY
- Contribution of proline to the pre-structuring tendency of transient helical secondary structure elements in intrinsically disordered proteins
- (2013) Chewook Lee et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Modeling neurodegenerative diseases in Caenorhabditis elegans
- (2013) Jia Li et al. EXPERIMENTAL NEUROLOGY
- Rapid Global Fitting of Large Fluorescence Lifetime Imaging Microscopy Datasets
- (2013) Sean C. Warren et al. PLoS One
- Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation
- (2013) S. L. Crick et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin
- (2013) Nicholas Stephane Caron et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- C. elegans Chemotaxis Assay
- (2013) Olivia Margie et al. Jove-Journal of Visualized Experiments
- Kinetically Competing Huntingtin Aggregation Pathways Control Amyloid Polymorphism and Properties
- (2012) Murali Jayaraman et al. BIOCHEMISTRY
- Structural Features and Domain Organization of Huntingtin Fibrils
- (2012) Charles W. Bugg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Fluorescence lifetime imaging - techniques and applications
- (2012) W. BECKER JOURNAL OF MICROSCOPY
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Polyglutamine Repeats Are Associated to Specific Sequence Biases That Are Conserved among Eukaryotes
- (2012) Matteo Ramazzotti et al. PLoS One
- Basic Caenorhabditis elegans Methods: Synchronization and Observation
- (2012) Montserrat Porta-de-la-Riva et al. Jove-Journal of Visualized Experiments
- A Statistical Analysis of the PPII Propensity of Amino Acid Guests in Proline-Rich Peptides
- (2011) Mahmoud Moradi et al. BIOPHYSICAL JOURNAL
- Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions
- (2011) Heidi Olzscha et al. CELL
- A FRET Sensor for Non-Invasive Imaging of Amyloid Formation in Vivo
- (2011) Gabriele S. Kaminski Schierle et al. CHEMPHYSCHEM
- Protein aggregates in Huntington's disease
- (2011) Montserrat Arrasate et al. EXPERIMENTAL NEUROLOGY
- The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils
- (2011) V. N. Sivanandam et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Identifying polyglutamine protein species in situ that best predict neurodegeneration
- (2011) Jason Miller et al. Nature Chemical Biology
- A novel approach to investigate tissue-specific trinucleotide repeat instability
- (2010) Jong-Min Lee et al. BMC Systems Biology
- Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences
- (2010) Vinal V. Lakhani et al. PLoS Computational Biology
- Jalview Version 2--a multiple sequence alignment editor and analysis workbench
- (2009) A. M. Waterhouse et al. BIOINFORMATICS
- Mechanism of Cis-Inhibition of PolyQ Fibrillation by PolyP: PPII Oligomers and the Hydrophobic Effect
- (2009) Gregory D. Darnell et al. BIOPHYSICAL JOURNAL
- Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset
- (2009) Meera Swami et al. HUMAN MOLECULAR GENETICS
- Protein sequences encode safeguards against aggregation
- (2009) Joke Reumers et al. HUMAN MUTATION
- Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism
- (2009) Ashwani K Thakur et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
- (2009) Xiaofeng Gu et al. NEURON
- Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
- (2009) A. Ben-Zvi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Secondary Structure of Huntingtin Amino-Terminal Region
- (2009) Mee Whi Kim et al. STRUCTURE
- Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases
- (2008) Ray Truant et al. FEBS Journal
- Increased Cognitive Functioning in Symptomatic Huntington's Disease As Revealed by Behavioral and Event-Related Potential Indices of Auditory Sensory Memory and Attention
- (2008) C. Beste et al. JOURNAL OF NEUROSCIENCE
- Misfolded proteins partition between two distinct quality control compartments
- (2008) Daniel Kaganovich et al. NATURE
- Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis
- (2008) Randal Halfmann et al. Jove-Journal of Visualized Experiments
- Phylogenetic Comparison of Huntingtin Homologues Reveals the Appearance of a Primitive polyQ in Sea Urchin
- (2007) M. Tartari et al. MOLECULAR BIOLOGY AND EVOLUTION
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now