Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I

Probing initial transient oligomerization events facilitating Huntingtin fibril nucleation at atomic resolution by relaxation-based NMR

(2019) Samuel A. Kotler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers

(2018) Ammon E. Posey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Huntingtin Exon-1 Peptides with Lipid-Based Micellar Nanoparticles Probed by Solution NMR and Q-Band Pulsed EPR

(2018) Alberto Ceccon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TiO2 Nanoparticles Catalyze Oxidation of Huntingtin Exon 1-Derived Peptides Impeding Aggregation: A Quantitative NMR Study of Binding and Kinetics

(2018) Alberto Ceccon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Singular NMR Fingerprint of a Polyproline II Helical Bundle

(2018) Miguel Ángel Treviño et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

(2017) Cristina Cariulo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington’s disease

(2017) Mingchen Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core

(2017) Hsiang-Kai Lin et al.   Nature Communications

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients

(2017) Andreas Neueder et al.   Scientific Reports

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

Huntingtin exon 1 fibrils feature an interdigitated β-hairpin–based polyglutamine core

(2016) Cody L. Hoop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils

(2015) J. Mario Isas et al.   BIOCHEMISTRY

Molecular View of Ligands Specificity for CAG Repeats in Anti-Huntington Therapy

(2015) Anna Bochicchio et al.   Journal of Chemical Theory and Computation

Huntington disease

(2015) Gillian P. Bates et al.   Nature Reviews Disease Primers

Super-Resolution Fluorescence of Huntingtin Reveals Growth of Globular Species into Short Fibers and Coexistence of Distinct Aggregates

(2014) Whitney C. Duim et al.   ACS Chemical Biology

Polyglutamine Amyloid Core Boundaries and Flanking Domain Dynamics in Huntingtin Fragment Fibrils Determined by Solid-State Nuclear Magnetic Resonance

(2014) Cody L. Hoop et al.   BIOCHEMISTRY

Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease

(2014) Brett A. Barbaro et al.   HUMAN MOLECULAR GENETICS

Quantification Assays for Total and Polyglutamine-Expanded Huntingtin Proteins

(2014) Douglas Macdonald et al.   PLoS One

Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation

(2013) S. L. Crick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increasing the Exchange Time-Scale That Can Be Probed by CPMG Relaxation Dispersion NMR

(2011) Pramodh Vallurupalli et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Small Changes, Big Impact

(2011) Dagmar E. Ehrnhoefer et al.   NEUROSCIENTIST

Refined solution structure of human profilin I

(2010) William J. Metzler et al.   PROTEIN SCIENCE

Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells

(2009) Tamara Ratovitski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

(2009) Ashwani K Thakur et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of Profilin by ROCK1 Regulates Polyglutamine Aggregation

(2008) J. Shao et al.   MOLECULAR AND CELLULAR BIOLOGY