The folding equilibrium of huntingtin exon 1 monomer depends on its polyglutamine tract

A General Strategy to Access Structural Information at Atomic Resolution in Polyglutamine Homorepeats

(2018) Annika Urbanek et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers

(2018) Ammon E. Posey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length

(2018) Estella A. Newcombe et al.   JOURNAL OF MOLECULAR BIOLOGY

Interaction of Huntingtin Exon-1 Peptides with Lipid-Based Micellar Nanoparticles Probed by Solution NMR and Q-Band Pulsed EPR

(2018) Alberto Ceccon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

(2018) Sean M. Deguire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 17-residue-long N terminus in huntingtin controls stepwise aggregation in solution and on membranes via different mechanisms

(2017) Nitin K. Pandey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths

(2017) John B. Warner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging β-Sheet Rich Conformations in Supercompact Huntingtin Exon-1 Mutant Structures

(2017) Hongsuk Kang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective

(2017) Maria Baias et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solid-State Nuclear Magnetic Resonance on the Static and Dynamic Domains of Huntingtin Exon-1 Fibrils

(2015) J. Mario Isas et al.   BIOCHEMISTRY

Primary cilia and autophagic dysfunction in Huntington’s disease

(2015) M Kaliszewski et al.   CELL DEATH AND DIFFERENTIATION

Structure of a Single-Chain Fv Bound to the 17 N-Terminal Residues of Huntingtin Provides Insights into Pathogenic Amyloid Formation and Suppression

(2015) Erwin De Genst et al.   JOURNAL OF MOLECULAR BIOLOGY

Anti-PolyQ Antibodies Recognize a Short PolyQ Stretch in Both Normal and Mutant Huntingtin Exon 1

(2015) Gwen E. Owens et al.   JOURNAL OF MOLECULAR BIOLOGY

Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?

(2014) Guylaine Hoffner et al.   MOLECULAR NEUROBIOLOGY

Polyglutamine- and Temperature-Dependent Conformational Rigidity in Mutant Huntingtin Revealed by Immunoassays and Circular Dichroism Spectroscopy

(2014) Valentina Fodale et al.   PLoS One

Pharmacological protein targets in polyglutamine diseases: Mutant polypeptides and their interactors

(2013) Boris A. Margulis et al.   FEBS LETTERS

Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues

(2013) Meewhi Kim   Prion

Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation

(2013) S. L. Crick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin

(2013) Nicholas Stephane Caron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetically Competing Huntingtin Aggregation Pathways Control Amyloid Polymorphism and Properties

(2012) Murali Jayaraman et al.   BIOCHEMISTRY

Structural Features and Domain Organization of Huntingtin Fibrils

(2012) Charles W. Bugg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disease-Associated Polyglutamine Stretches in Monomeric Huntingtin Adopt a Compact Structure

(2012) Clare Peters-Libeu et al.   JOURNAL OF MOLECULAR BIOLOGY

A Compact β Model of huntingtin Toxicity

(2011) Qi Charles Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Slow Amyloid Nucleation via α-Helix-Rich Oligomeric Intermediates in Short Polyglutamine-Containing Huntingtin Fragments

(2011) Murali Jayaraman et al.   JOURNAL OF MOLECULAR BIOLOGY

The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils

(2011) V. N. Sivanandam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Age, CAG repeat length, and clinical progression in Huntington's disease

(2011) Adam Rosenblatt et al.   MOVEMENT DISORDERS

Identifying polyglutamine protein species in situ that best predict neurodegeneration

(2011) Jason Miller et al.   Nature Chemical Biology

Modulation of Polyglutamine Conformations and Dimer Formation by the N-Terminus of Huntingtin

(2009) Tim E. Williamson et al.   JOURNAL OF MOLECULAR BIOLOGY

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

(2009) Stephen Tam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

(2009) Xiaofeng Gu et al.   NEURON

Secondary Structure of Huntingtin Amino-Terminal Region

(2009) Mee Whi Kim et al.   STRUCTURE

Huntington’s disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases

(2008) Ray Truant et al.   FEBS Journal