Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents

Hawthorn fruit extract reduced trimethylamine-N-oxide (TMAO)-exacerbated atherogenesis in mice via anti-inflammation and anti-oxidation

(2021) Zouyan He et al.   Nutrition & Metabolism

Interleukin‐12/23 deficiency differentially affects pathology in male and female Alzheimer's disease‐like mice

(2020) Pascale Eede et al.   EMBO REPORTS

Oxidative Stress and Gut-Derived Lipopolysaccharides in Neurodegenerative Disease: Role of NOX2

(2020) Lorenzo Loffredo et al.   Oxidative Medicine and Cellular Longevity

Microbial imbalance in inflammatory bowel disease patients at different taxonomic levels

(2020) Mohammad Tauqeer Alam et al.   Gut Pathogens

Murine Gut Microbiome Association With APOE Alleles

(2020) Ishita J. Parikh et al.   Frontiers in Immunology

The blood–brain barrier in health and disease: Important unanswered questions

(2020) Caterina P. Profaci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Effect of ApoE isoforms on mitochondria in Alzheimer disease

(2020) Junxiang Yin et al.   NEUROLOGY

Sleep and Diurnal Rest-Activity Rhythm Disturbances in a Mouse Model of Alzheimer’s Disease

(2020) Mikolaj J Filon et al.   SLEEP

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer’s disease

(2020) Maria Calvo-Rodriguez et al.   Nature Communications

Traditional Chinese Medicine: Role in Reducing β-Amyloid, Apoptosis, Autophagy, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction of Alzheimer’s Disease

(2020) Shi-Yu Chen et al.   Frontiers in Pharmacology

Actigraphy‐estimated sleep and 24‐hour activity rhythms and the risk of dementia

(2020) Thom S. Lysen et al.   Alzheimers & Dementia

Apolipoprotein E4 disrupts the neuroprotective action of sortilin in neuronal lipid metabolism and endocannabinoid signaling

(2020) Antonino Asaro et al.   Alzheimers & Dementia

miR-16-5p is upregulated by amyloid β deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2

(2020) Yeong-Jin Kim et al.   EXPERIMENTAL GERONTOLOGY

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

(2020) Vienna E. Brunt et al.   HYPERTENSION

Dexmedetomidine Provides Protection Against Hippocampal Neuron Apoptosis and Cognitive Impairment in Mice with Alzheimer’s Disease by Mediating the miR-129/YAP1/JAG1 Axis

(2020) Weiying Sun et al.   MOLECULAR NEUROBIOLOGY

Positive association of a Sirt1 variant and parameters of oxidative stress on Alzheimer’s disease

(2020) Daniela Camporez et al.   NEUROLOGICAL SCIENCES

SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology

(2019) Anna R. Malik et al.   Cell Reports

Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males

(2019) Maartje C. P. Cleophas et al.   Scientific Reports

APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer’s disease pathophysiology

(2019) Tam T. T. Tran et al.   FASEB JOURNAL

Type II Diabetes Interacts With Alzheimer Disease Risk Factors to Predict Functional Decline

(2019) Kelsey R. Thomas et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

The role of thiols in antioxidant systems

(2019) Kathrin Ulrich et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota

(2019) Binyin Li et al.   Alzheimers & Dementia

Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression

(2019) Xinyi Wang et al.   CELL RESEARCH

Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model

(2019) Min-Soo Kim et al.   GUT

Increased Trimethylamine N-Oxide Is Not Associated with Oxidative Stress Markers in Healthy Aged Women

(2019) Robert Antoni Olek et al.   Oxidative Medicine and Cellular Longevity

APOE ε4 is associated with younger age at ischemic stroke onset but not with stroke outcome

(2019) Cecilia Lagging et al.   NEUROLOGY

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

(2019) Pooja Jadiya et al.   Nature Communications

The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis

(2019) Bahar Yetkin-Arik et al.   Scientific Reports

Neuroinflammation and the Gut Microbiota: Possible Alternative Therapeutic Targets to Counteract Alzheimer’s Disease?

(2019) Milica Cerovic et al.   Frontiers in Aging Neuroscience

Diabetes as a risk factor for Alzheimer’s disease in the Middle East and its shared pathological mediators

(2019) Richard L. Jayaraj et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Oxidative stress as a biomarker for Alzheimer's disease

(2018) Fabrice Collin et al.   Biomarkers in Medicine

Elevated expression of ageing and immunity genes in queens of the black garden ant

(2018) Eric R. Lucas et al.   EXPERIMENTAL GERONTOLOGY

Nutrition: Review on the Possible Treatment for Alzheimer’s Disease

(2018) Benson O.A. Botchway et al.   JOURNAL OF ALZHEIMERS DISEASE

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Sirtuin 1 and Alzheimer's disease: An up-to-date review

(2018) Liara Rizzi et al.   NEUROPEPTIDES

A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration

(2018) Clara Hiu-Ling Hung et al.   Redox Biology

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

An APOE Haplotype Associated with Decreased ε4 Expression Increases the Risk of Late Onset Alzheimer's Disease

(2018) Francesco Lescai et al.   JOURNAL OF ALZHEIMERS DISEASE

A Randomized Placebo-Controlled Pilot Trial of Omega-3 Fatty Acids and Alpha Lipoic Acid in Alzheimer's Disease

(2018) Lynne Shinto et al.   JOURNAL OF ALZHEIMERS DISEASE

Redox Proteomics and Amyloid β-Peptide: Insights into Alzheimer Disease

(2018) D Allan Butterfield et al.   JOURNAL OF NEUROCHEMISTRY

Understanding the Role of ApoE Fragments in Alzheimer’s Disease

(2018) Sonia Sanz Muñoz et al.   NEUROCHEMICAL RESEARCH

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

(2018) Nicholas M. Vogt et al.   Alzheimers Research & Therapy

Functional and therapeutic potential of mitochondrial SIRT3 deacetylase in disease conditions

(2018) Abhinav Kanwal   Expert Review of Clinical Pharmacology

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms

(2017) Lap Ho et al.   Expert Review of Neurotherapeutics

Mitochondrial catalase induces cells transformation through nucleolin-dependent Cox-2 mRNA stabilization

(2017) Xin Liao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure

(2017) Jędrzej Szymański et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Hidden Twins: SorCS Neuroreceptors Form Stable Dimers

(2017) Dovile Januliene et al.   JOURNAL OF MOLECULAR BIOLOGY

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

(2017) Charbel Moussa et al.   Journal of Neuroinflammation

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms

(2017) Lap Ho et al.   Expert Review of Neurotherapeutics

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

(2017) Yuhai Zhao et al.   Frontiers in Cellular and Infection Microbiology

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress

(2017) Tiejun Li et al.   Frontiers in Physiology

Oxidative stress affects processing of amyloid precursor protein in vascular endothelial cells

(2017) Abebe Muche et al.   PLoS One

A novel oxidative stress marker in patients with Alzheimer’s disease: dynamic thiol–disulphide homeostasis

(2016) Sadiye Gumusyayla et al.   ACTA NEUROPSYCHIATRICA

APOE2eases cognitive decline during Aging: Clinical and preclinical evaluations

(2016) Mitsuru Shinohara et al.   ANNALS OF NEUROLOGY

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients

(2016) Fabio Di Domenico et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional role of mitochondrial reactive oxygen species in physiology

(2016) Plamena R. Angelova et al.   FREE RADICAL BIOLOGY AND MEDICINE

A Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer’s Disease

(2016) Carl-Henrik Andersson et al.   JOURNAL OF ALZHEIMERS DISEASE

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders

(2016) Robert W. Mahley   JOURNAL OF MOLECULAR MEDICINE-JMM

Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

(2016) Timothy G. Dinan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Apolipoprotein E ε4 Allele was Associated With Nonlesional Mesial Temporal Lobe Epilepsy in Han Chinese Population

(2016) Zhimei Li et al.   MEDICINE

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

Gram-negative bacterial molecules associate with Alzheimer disease pathology

(2016) Xinhua Zhan et al.   NEUROLOGY

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of gut microbiota and nutrients in amyloid formation and pathogenesis of Alzheimer disease

(2016) Francesca Pistollato et al.   NUTRITION REVIEWS

Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins

(2016) Xia-Chun Li et al.   Scientific Reports

A novel oxidative stress marker in patients with Alzheimer’s disease: dynamic thiol–disulphide homeostasis

(2016) Sadiye Gumusyayla et al.   ACTA NEUROPSYCHIATRICA

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle

(2016) Orsolya M. Palacios et al.   Aging-US

ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer’s disease mouse model

(2016) Elizabeth S. Chan et al.   Scientific Reports

Altered fecal microbiota composition in patients with major depressive disorder

(2015) Haiyin Jiang et al.   BRAIN BEHAVIOR AND IMMUNITY

Mitochondrial superoxide dismutase deficiency accelerates chronological aging in the fission yeastSchizosaccharomyces pombe

(2015) Toshiya Ogata et al.   CELL BIOLOGY INTERNATIONAL

Association of the C47T Polymorphism in SOD2 with Amnestic Mild Cognitive Impairment and Alzheimer’s Disease in Carriers of the APOEε4 Allele

(2015) David Gamarra et al.   DISEASE MARKERS

PGC-1α overexpression by in vivo transfection attenuates mitochondrial deterioration of skeletal muscle caused by immobilization

(2015) Chounghun Kang et al.   FASEB JOURNAL

Identification of an anti-inflammatory protein fromFaecalibacterium prausnitzii, a commensal bacterium deficient in Crohn’s disease

(2015) E Quévrain et al.   GUT

Aerobic Training Increases Expression Levels of SIRT3 and PGC-1α in Skeletal Muscle of Overweight Adolescents Without Change in Caloric Intake

(2015) Katya Vargas-Ortiz et al.   PEDIATRIC EXERCISE SCIENCE

Insights into the Role of Erysipelotrichaceae in the Human Host

(2015) Nadeem O. Kaakoush   Frontiers in Cellular and Infection Microbiology

Antioxidant responses and cellular adjustments to oxidative stress

(2015) Cristina Espinosa-Diez et al.   Redox Biology

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease

(2014) Maurice W. Dysken et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Intestinal Microbiota, Microbial Translocation, and Systemic Inflammation in Chronic HIV Infection

(2014) Duy M. Dinh et al.   JOURNAL OF INFECTIOUS DISEASES

Axonal Transport Defects in Alzheimer’s Disease

(2014) Zi-Xuan Wang et al.   MOLECULAR NEUROBIOLOGY

rs2070424 of the SOD1 gene is associated with risk of Alzheimer's disease

(2014) Karolina Spisak et al.   Neurologia i Neurochirurgia Polska

Correction: Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer’s Disease and Related Dementias

(2014)   PLoS Genetics

Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: a 6-month, randomized, placebo-controlled, multicenter trial

(2014) Moshe Laudon et al.   Clinical Interventions in Aging

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Vascular Oxidative Stress and Mitochondrial Failure in the Pathobiology of Alzheimer’s Disease: A New Approach to Therapy

(2013) Marta Sochocka et al.   CNS & Neurological Disorders-Drug Targets

Oxidative stress and APO E polymorphisms in Alzheimer's disease and in mild cognitive impairment

(2013) L. Chico et al.   FREE RADICAL RESEARCH

De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease

(2013) Hon-Kit Andus Wong et al.   HUMAN MOLECULAR GENETICS

TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer’s disease in Han Chinese

(2013) Rui-Chun Lu et al.   JOURNAL OF NEURAL TRANSMISSION

Tau phosphorylation affects its axonal transport and degradation

(2013) Teresa Rodríguez-Martín et al.   NEUROBIOLOGY OF AGING

Human copper chaperone for superoxide dismutase 1 mediates its own oxidation-dependent import into mitochondria

(2013) Yutaka Suzuki et al.   Nature Communications

Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)

(2013) C Reitz et al.   Translational Psychiatry

Diet-Induced Alterations of Host Cholesterol Metabolism Are Likely To Affect the Gut Microbiota Composition in Hamsters

(2012) Inés Martínez et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population

(2012) Hui-Fu Wang et al.   BRAIN RESEARCH

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Regulation of Mitochondrial Transport and Inter-Microtubule Spacing by Tau Phosphorylation at the Sites Hyperphosphorylated in Alzheimer's Disease

(2012) K. Shahpasand et al.   JOURNAL OF NEUROSCIENCE

Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline

(2012) Johannes vom Berg et al.   NATURE MEDICINE

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain

(2011) Mark A. Lovell et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

(2010) Shinichi Someya et al.   CELL

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Detergent-Insoluble EAAC1/EAAT3 Aberrantly Accumulates in Hippocampal Neurons of Alzheimer's Disease Patients

(2008) Kevin Duerson et al.   BRAIN PATHOLOGY