Dexmedetomidine Provides Protection Against Hippocampal Neuron Apoptosis and Cognitive Impairment in Mice with Alzheimer’s Disease by Mediating the miR-129/YAP1/JAG1 Axis

Neuronal Protein Tyrosine Phosphatase 1B Hastens Amyloid β-Associated Alzheimer's Disease in Mice

(2020) Konrad M. Ricke et al.   JOURNAL OF NEUROSCIENCE

An aptamer based fluorometric assay for amyloid-β oligomers using a metal-organic framework of type Ru@MIL-101(Al) and enzyme-assisted recycling

(2020) Hong-Xia Ren et al.   MICROCHIMICA ACTA

Behavioural and psychological symptoms of dementia in mouse models of Alzheimer’s disease-related pathology

(2020) Filip Kosel et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma

(2020) Kayoung Kim et al.   Nature Communications

Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis

(2019) Yi-Bing Sun et al.   Cell Death & Disease

Upregulation of microRNA‐196a improves cognitive impairment and alleviates neuronal damage in hippocampus tissues of Alzheimer's disease through downregulating LRIG3 expression

(2019) Ke Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer’s disease

(2019) Soheil Madadi et al.   Cell and Bioscience

Mitochondria-targeted TPP-MoS2 with dual enzyme activity provides efficient neuroprotection through M1/M2 microglial polarization in an Alzheimer's disease model

(2019) Chaoxiu Ren et al.   BIOMATERIALS

Dexmedetomidine modulates neuroinflammation and improves outcome via alpha2-adrenergic receptor signaling after rat spinal cord injury

(2019) Jiandong Gao et al.   BRITISH JOURNAL OF ANAESTHESIA

Poloxamer-chitosan-based Naringenin nanoformulation used in brain targeting for the treatment of cerebral ischemia

(2019) Niyaz Ahmad et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease

(2018) Min Xu et al.   Alzheimers & Dementia

Inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury

(2018) Di Li et al.   CNS Neuroscience & Therapeutics

microRNA-129-5p Involved in the Neuroprotective Effect of Dexmedetomidine on Hypoxic-Ischemic Brain Injury by Targeting COL3A1 through the Wnt/β-Catenin Signaling Pathway in Neonatal Rats

(2018) Xiu-Min Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of microRNA-129 and its target gene c-Fos on proliferation and apoptosis of hippocampal neurons in rats with epilepsy via the MAPK signaling pathway

(2018) Dong-Mei Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

miR-34a deficiency in APP/PS1 mice promotes cognitive function by increasing synaptic plasticity via AMPA and NMDA receptors

(2018) Yuelong Xu et al.   NEUROSCIENCE LETTERS

Yes‑associated protein 1 promotes the metastasis of U251 glioma cells by upregulating Jagged‑1 expression and activating the Notch signal pathway

(2018) Bin Hao et al.   Experimental and Therapeutic Medicine

The Role of microRNAs in Alzheimer’s Disease and Their Therapeutic Potentials

(2018) Munvar Miya Shaik et al.   Genes

miR‑223‑3p/TIAL1 interaction is involved in the mechanisms associated with the neuroprotective effects of dexmedetomidine on hippocampal neuronal cells in�vitro

(2018) Qi Wang et al.   Molecular Medicine Reports

miR-598 inhibits metastasis in colorectal cancer by suppressing JAG1/Notch2 pathway stimulating EMT

(2017) Jia Chen et al.   EXPERIMENTAL CELL RESEARCH

MicroRNA-622 suppresses the proliferation of glioma cells by targeting YAP1

(2017) Jin Xu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dexmedetomidine Inhibits Osteosarcoma Cell Proliferation and Migration, and Promotes Apoptosis by Regulating MiR-520a-3p

(2017) Xiaoyan Wang et al.   ONCOLOGY RESEARCH

TNFα-YAP/p65-HK2 axis mediates breast cancer cell migration

(2017) Y Gao et al.   Oncogenesis

MicroRNA-186 targets Yes-associated protein 1 to inhibit Hippo signaling and tumorigenesis in hepatocellular carcinoma

(2016) TINGYAN RUAN et al.   Oncology Letters

Dexmedetomidine: A Review of Its Use for Sedation in the Intensive Care Setting

(2015) Gillian M. Keating   DRUGS

Dexmedetomidine improves early postoperative cognitive dysfunction in aged mice

(2015) Xiao-Lan Qian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Electroacupuncture Suppressed Neuronal Apoptosis and Improved Cognitive Impairment in the AD Model Rats Possibly via Downregulation of Notch Signaling Pathway

(2015) Hai-dong Guo et al.   Evidence-based Complementary and Alternative Medicine

The Notch ligand Jagged1 as a target for anti-tumor therapy

(2014) Demin Li   Frontiers in Oncology

Alteration of the microRNA network during the progression of Alzheimer's disease

(2013) Pierre Lau et al.   EMBO Molecular Medicine

A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin, and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke

(2013) Niyaz Ahmad et al.   PROTOPLASMA

Possible involvement of notch signaling in the pathogenesis of Buerger’s disease

(2013) Hiroaki Tamai et al.   SURGERY TODAY

BACE1 Regulates Hippocampal Astrogenesis via the Jagged1-Notch Pathway

(2013) Xiangyou Hu et al.   Cell Reports

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Hippocampal atrophy rates in Alzheimer's disease: Automated segmentation variability analysis

(2011) Abderazzak Mouiha et al.   NEUROSCIENCE LETTERS

Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats

(2009) Robert D. Sanders et al.   ANESTHESIOLOGY