ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer’s disease mouse model

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice

(2015) De-shan Liu et al.   Molecular Neurodegeneration

Regulation of AMPA receptor subunit GluA1 surface expression by PAK3 phosphorylation

(2015) Natasha K. Hussain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease

(2015) L. Kunz et al.   SCIENCE

APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults

(2015) J. P. Shine et al.   Scientific Reports

Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice

(2015) Elizabeth S Chan et al.   Scientific Reports

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

Apolipoprotein E in Alzheimer's Disease: An Update

(2014) Jin-Tai Yu et al.   Annual Review of Neuroscience

Insulin induces phosphorylation of the AMPA receptor subunit GluR1, reversed by ZIP, and over-expression of Protein Kinase M zeta, reversed by amyloid beta

(2014) Linda Adzovic et al.   JOURNAL OF NEUROCHEMISTRY

Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice

(2014) Shan-May Yong et al.   Scientific Reports

AMPARs and Synaptic Plasticity: The Last 25 Years

(2013) Richard L. Huganir et al.   NEURON

Apolipoprotein E4 Causes Age- and Sex-Dependent Impairments of Hilar GABAergic Interneurons and Learning and Memory Deficits in Mice

(2013) Laura Leung et al.   PLoS One

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

(2012) Katherine L. Youmans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent A  Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice

(2012) N. Bien-Ly et al.   JOURNAL OF NEUROSCIENCE

Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration

(2012) J. R. Sundaram et al.   JOURNAL OF NEUROSCIENCE

Preventing Alzheimer's Disease

(2012) D. J. Selkoe   SCIENCE

PI3K-PKB/Akt Pathway

(2012) B. A. Hemmings et al.   Cold Spring Harbor Perspectives in Biology

C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-  (A ) and acts in concert with A  to elicit neuronal and behavioral deficits in mice

(2011) N. Bien-Ly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific Roles of AMPA Receptor Subunit GluR1 (GluA1) Phosphorylation Sites in Regulating Synaptic Plasticity in the CA1 Region of Hippocampus

(2009) Hey-Kyoung Lee et al.   JOURNAL OF NEUROPHYSIOLOGY

Human APOE Isoform-Dependent Effects on Brain  -Amyloid Levels in PDAPP Transgenic Mice

(2009) K. R. Bales et al.   JOURNAL OF NEUROSCIENCE

Reduced levels of human apoE4 protein in an animal model of cognitive impairment

(2009) P.M. Sullivan et al.   NEUROBIOLOGY OF AGING

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

(2008) D. R. Riddell et al.   JOURNAL OF NEUROSCIENCE

APOE  4 allele predicts faster cognitive decline in mild Alzheimer disease

(2008) S. Cosentino et al.   NEUROLOGY

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Insulin rescues amyloid β-induced impairment of hippocampal long-term potentiation

(2007) Cheng-Che Lee et al.   NEUROBIOLOGY OF AGING