The role of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis

Endothelial tip cells in vitro are less glycolytic and have a more flexible response to metabolic stress than non-tip cells

(2019) B. Yetkin-Arik et al.   Scientific Reports

Hydrogen Peroxide–Releasing Hydrogels for Enhanced Endothelial Cell Activities and Neovascularization

(2018) Yunki Lee et al.   ACS Applied Materials & Interfaces

IGF2 and IGF1R identified as novel tip cell genes in primary microvascular endothelial cell monolayers

(2018) Marchien G. Dallinga et al.   ANGIOGENESIS

Consensus guidelines for the use and interpretation of angiogenesis assays

(2018) Patrycja Nowak-Sliwinska et al.   ANGIOGENESIS

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

In silico gene expression analysis reveals glycolysis and acetate anaplerosis in IDH1 wild-type glioma and lactate and glutamate anaplerosis in IDH1-mutated glioma

(2017) Mohammed Khurshed et al.   Oncotarget

Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1α-deficient mice

(2016) Nieves García-Quintans et al.   ANGIOGENESIS

Regulation of endothelial dynamics by PGC-1α relies on ROS control of VEGF-A signaling

(2016) Nieves García-Quintans et al.   FREE RADICAL BIOLOGY AND MEDICINE

The angiogenic switch leads to a metabolic shift in human glioblastoma

(2016) Krishna M. Talasila et al.   NEURO-ONCOLOGY

Determining Maximum Glycolytic Capacity Using Extracellular Flux Measurements

(2016) Shona A. Mookerjee et al.   PLoS One

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

(2015) Andrea Weiss et al.   ANGIOGENESIS

Interactions between mitochondrial reactive oxygen species and cellular glucose metabolism

(2015) Dania C. Liemburg-Apers et al.   ARCHIVES OF TOXICOLOGY

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

The chicken chorioallantoic membrane model in biology, medicine and bioengineering

(2014) Patrycja Nowak-Sliwinska et al.   ANGIOGENESIS

Endothelial PFKFB3 Plays a Critical Role in Angiogenesis

(2014) Yiming Xu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing

(2014) Oliver Coutelle et al.   EMBO Molecular Medicine

Principles of targeting endothelial cell metabolism to treat angiogenesis and endothelial cell dysfunction in disease

(2014) J. Goveia et al.   EMBO Molecular Medicine

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

Mitochondria and Endothelial Function

(2013) Matthew A. Kluge et al.   CIRCULATION RESEARCH

Endothelial cell metabolism and tumour angiogenesis: glucose and glutamine as essential fuels and lactate as the driving force

(2013) F. Polet et al.   JOURNAL OF INTERNAL MEDICINE

Mild Phenotype in a Male with Pyruvate Dehydrogenase Complex Deficiency Associated with Novel Hemizygous In-Frame Duplication of the E1α Subunit Gene (PDHA1)

(2013) J. Steller et al.   NEUROPEDIATRICS

Lactate Dehydrogenase A Expression Is Necessary to Sustain Rapid Angiogenesis of Pulmonary Microvascular Endothelium

(2013) Glenda Parra-Bonilla et al.   PLoS One

Increased mitochondrial activity in a novel IDH1-R132H mutant human oligodendroglioma xenograft model: in situ detection of 2-HG and α-KG

(2013) Anna C Navis et al.   Acta Neuropathologica Communications

CD34 marks angiogenic tip cells in human vascular endothelial cell cultures

(2012) Martin J. Siemerink et al.   ANGIOGENESIS

Endothelial Tip Cells in Ocular Angiogenesis

(2012) Martin J. Siemerink et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis

(2012) Pierre Sonveaux et al.   PLoS One

Image Cytometry: Protocols for 2D and 3D Quantification in Microscopic Images

(2012) Pasquale Chieco et al.   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription

(2012) A.-B. Al-Mehdi et al.   Science Signaling

Regulation of Endothelial Function by Mitochondrial Reactive Oxygen Species

(2011) Michael E. Widlansky et al.   ANTIOXIDANTS & REDOX SIGNALING

Lactate Influx through the Endothelial Cell Monocarboxylate Transporter MCT1 Supports an NF- B/IL-8 Pathway that Drives Tumor Angiogenesis

(2011) F. Vegran et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Coordinating cell behaviour during blood vessel formation

(2011) I. Geudens et al.   DEVELOPMENT

The spectrum of pyruvate dehydrogenase complex deficiency: Clinical, biochemical and genetic features in 371 patients

(2011) Kavi P. Patel et al.   MOLECULAR GENETICS AND METABOLISM

Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma?

(2010) Caroline Jose et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species

(2010) Brian P. Dranka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

The Neovessel Occlusion Efficacy of 151-Hydroxypurpurin-7-Lactone Dimethyl Ester Induced with Photodynamic Therapy

(2010) Siang Hui Lim et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic transformation in cancer

(2009) D. A. Tennant et al.   CARCINOGENESIS

Altered expression of genes related to blood–retina barrier disruption in streptozotocin-induced diabetes

(2009) Ingeborg Klaassen et al.   EXPERIMENTAL EYE RESEARCH

Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells

(2009) Harun Elmasri et al.   FASEB JOURNAL

AMPK in Health and Disease

(2009) Gregory R. Steinberg et al.   PHYSIOLOGICAL REVIEWS

Advances in measuring cellular bioenergetics using extracellular flux

(2008) David A. Ferrick et al.   DRUG DISCOVERY TODAY

Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence

(2008) Michael Schleicher et al.   JOURNAL OF CELL BIOLOGY

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION