Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice

(2019) Vienna E. Brunt et al.   JOURNAL OF PHYSIOLOGY-LONDON

Increased circulating trimethylamine N-oxide plays a contributory role in the development of endothelial dysfunction and hypertension in the RUPP rat model of preeclampsia

(2019) Hui Chen et al.   HYPERTENSION IN PREGNANCY

Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans

(2019) Dick H J Thijssen et al.   EUROPEAN HEART JOURNAL

Increased circulating trimethylamine N-oxide contributes to endothelial dysfunction in a rat model of chronic kidney disease

(2018) Tiejun Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress

(2018) Yilang Ke et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic Supplementation With a Mitochondrial Antioxidant (MitoQ) Improves Vascular Function in Healthy Older AdultsNovelty and Significance

(2018) Matthew J. Rossman et al.   HYPERTENSION

Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice

(2018) Rachel A. Gioscia-Ryan et al.   JOURNAL OF APPLIED PHYSIOLOGY

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

(2017) Ming‐liang Chen et al.   Journal of the American Heart Association

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress

(2017) Tiejun Li et al.   Frontiers in Physiology

Vascular endothelium – Gatekeeper of vessel health

(2016) Paul A. Cahill et al.   ATHEROSCLEROSIS

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Towards understanding brain-gut-microbiome connections in Alzheimer’s disease

(2016) Rong Xu et al.   BMC Systems Biology

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

Increased Trimethylamine N- Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus

(2016) W. H. Wilson Tang et al.   CLINICAL CHEMISTRY

Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults

(2016) Allison E. DeVan et al.   JOURNAL OF APPLIED PHYSIOLOGY

Intestinal Microbiota‐Generated Metabolite Trimethylamine‐N‐Oxide and 5‐Year Mortality Risk in Stable Coronary Artery Disease: The Contributory Role of Intestinal Microbiota in a COURAGE‐Like Patient Cohort

(2016) Vichai Senthong et al.   Journal of the American Heart Association

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

(2016) Marcus M. Seldin et al.   Journal of the American Heart Association

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Short-term high-fat diet increases postprandial trimethylamine- N -oxide in humans

(2015) Nabil E. Boutagy et al.   NUTRITION RESEARCH

Probiotic supplementation and trimethylamine-N-oxide production following a high-fat diet

(2015) Nabil E. Boutagy et al.   Obesity

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide

(2015) Kymberleigh A. Romano et al.   mBio

Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry

(2014) Zeneng Wang et al.   ANALYTICAL BIOCHEMISTRY

The Vascular Endothelium and Human Diseases

(2014) Peramaiyan Rajendran et al.   International Journal of Biological Sciences

Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice

(2014) Rachel A. Gioscia-Ryan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

(2013) Robert A Koeth et al.   NATURE MEDICINE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vascular aging: Chronic oxidative stress and impairment of redox signaling—consequences for vascular homeostasis and disease

(2012) Markus M. Bachschmid et al.   ANNALS OF MEDICINE

Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme

(2012) S. Craciun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging

(2011) Amy L. Sindler et al.   AGING CELL

Aging and vascular endothelial function in humans

(2011) Douglas R. Seals et al.   CLINICAL SCIENCE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

(2010) Catarina Rippe et al.   AGING CELL

Composition, variability, and temporal stability of the intestinal microbiota of the elderly

(2010) M. J. Claesson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

eNOS uncoupling and endothelial dysfunction in aged vessels

(2009) Yang-Ming Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Nuclear Factor-κB Activation Contributes to Vascular Endothelial Dysfunction via Oxidative Stress in Overweight/Obese Middle-Aged and Older Humans

(2009) Gary L. Pierce et al.   CIRCULATION

Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease

(2008) Michael Shechter et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY