Characterization and miRNA Profiling of Extracellular Vesicles from Human Osteoarthritic Subchondral Bone Multipotential Stromal Cells (MSCs)

Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-κB dependent inflammatory/catabolic environment of osteoarthritis

(2021) Carola Cavallo et al.   Scientific Reports

Secreted Factors and EV-miRNAs Orchestrate the Healing Capacity of Adipose Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis

(2020) Enrico Ragni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

microRNA and exosome profiling in multiple sclerosis

(2020) Marcin P Mycko et al.   Multiple Sclerosis Journal

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017

(2020) Saeid Safiri et al.   ANNALS OF THE RHEUMATIC DISEASES

Impact of Type 2 Diabetes Mellitus on Human Bone Marrow Stromal Cell Number and Phenotypic Characteristics

(2020) Féaron C. Cassidy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Altered protein levels in bone marrow lesions of hip osteoarthritis: Analysis by proteomics and multiplex immunoassays

(2020) Maziar Shabestari et al.   International Journal of Rheumatic Diseases

Sequencing identifies a distinct signature of circulating microRNAs in early radiographic knee osteoarthritis

(2020) S.A. Ali et al.   OSTEOARTHRITIS AND CARTILAGE

Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis

(2020) Ching-Heng Chou et al.   Scientific Reports

In Vitro Study of Extracellular Vesicles Migration in Cartilage-Derived Osteoarthritis Samples Using Real-Time Quantitative Multimodal Nonlinear Optics Imaging

(2020) Leonardo Mortati et al.   Pharmaceutics

hBMSC-Derived Extracellular Vesicles Attenuate IL-1β-Induced Catabolic Effects on OA-Chondrocytes by Regulating Pro-inflammatory Signaling Pathways

(2020) Shushan Li et al.   Frontiers in Bioengineering and Biotechnology

Sex-Specific Differences in Extracellular Vesicle Protein Cargo in Synovial Fluid of Patients with Osteoarthritis

(2020) Ravindra Kolhe et al.   Life-Basel

Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis

(2019) Jiao Li et al.   Nanomaterials

Impact of Diabetes Mellitus on Human Mesenchymal Stromal Cell Biology and Functionality: Implications for Autologous Transplantation

(2019) Marwa Mahmoud et al.   Stem Cell Reviews and Reports

Role of Epigenomics in Bone and Cartilage Disease

(2019) Joyce BJ van Meurs et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling

(2019) Hai-Chao Dong et al.   INFLAMMATION

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

(2019) Shipin Zhang et al.   BIOMATERIALS

The simultaneous analysis of mesenchymal stem cells and early osteocytes accumulation in osteoarthritic femoral head sclerotic bone

(2019) Dragos C Ilas et al.   RHEUMATOLOGY

Gene expression and functional comparison between multipotential stromal cells from lateral and medial condyles of knee osteoarthritis patients

(2019) Clara Sanjurjo-Rodriguez et al.   Scientific Reports

MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes

(2019) Zafar Rasheed et al.   Scientific Reports

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Association between cytokines and exosomes in synovial fluid of individuals with knee osteoarthritis

(2019) Kun Gao et al.   Modern Rheumatology

The reactome pathway knowledgebase

(2019) Bijay Jassal et al.   NUCLEIC ACIDS RESEARCH

Exosomes in intercellular communication and implications for osteoarthritis

(2019) Sabha Asghar et al.   RHEUMATOLOGY

TGFBI secreted by mesenchymal stromal cells ameliorates osteoarthritis and is detected in extracellular vesicles

(2019) Maxime Ruiz et al.   BIOMATERIALS

Single-cell RNA-seq analysis reveals the progression of human osteoarthritis

(2018) Quanbo Ji et al.   ANNALS OF THE RHEUMATIC DISEASES

Emerging Role of Exosomes in the Joint Diseases

(2018) Zeng Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Extracellular vesicles in cartilage homeostasis and osteoarthritis

(2018) Shigeru Miyaki et al.   CURRENT OPINION IN RHEUMATOLOGY

Comprehensive miRNA Analysis of Human Umbilical Cord-Derived Mesenchymal Stromal Cells and Extracellular Vesicles

(2018) Xiang-yu Zou et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Comparison of secretome from osteoblasts derived from sclerotic versus non-sclerotic subchondral bone in OA: A pilot study

(2018) Christelle Sanchez et al.   PLoS One

FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis

(2018) Tokio Matsuzaki et al.   Science Translational Medicine

Early Changes of Articular Cartilage and Subchondral Bone in The DMM Mouse Model of Osteoarthritis

(2018) Hang Fang et al.   Scientific Reports

Fatty acids and osteoarthritis: different types, different effects

(2018) Marieke Loef et al.   JOINT BONE SPINE

miRWalk: An online resource for prediction of microRNA binding sites

(2018) Carsten Sticht et al.   PLoS One

Mechanical stress contributes to osteoarthritis development through the activation of transforming growth factor beta 1 (TGF-β1)

(2018) R-K. Zhang et al.   Bone & Joint Research

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Dendritic Cell Maturation and Function

(2018) Monica Reis et al.   Frontiers in Immunology

Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles

(2017) Stella Cosenza et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of the Proinflammatory Profile of Synovial Fluid-Derived Exosomes of Patients with Osteoarthritis

(2017) Rossana Domenis et al.   MEDIATORS OF INFLAMMATION

mirDIP 4.1—integrative database of human microRNA target predictions

(2017) Tomas Tokar et al.   NUCLEIC ACIDS RESEARCH

Progress in Exosome Isolation Techniques

(2017) Pin Li et al.   Theranostics

A Dual Role of Upper Zone of Growth Plate and Cartilage Matrix-Associated Protein in Human and Mouse Osteoarthritic Cartilage: Inhibition of Aggrecanases and Promotion of Bone Turnover

(2017) Michael Stock et al.   Arthritis & Rheumatology

Mechanisms of Osteoarthritic Pain. Studies in Humans and Experimental Models

(2017) Annett Eitner et al.   Frontiers in Molecular Neuroscience

Identification of miR-16 as an endogenous reference gene for the normalization of urinary exosomal miRNA expression data from CKD patients

(2017) Tim Lange et al.   PLoS One

Gender-specific differential expression of exosomal miRNA in synovial fluid of patients with osteoarthritis

(2017) Ravindra Kolhe et al.   Scientific Reports

The role of subchondral bone damage in post-traumatic osteoarthritis

(2016) Thomas R. Coughlin et al.   Annals of the New York Academy of Sciences

MicroRNA-142-3p Inhibits Chondrocyte Apoptosis and Inflammation in Osteoarthritis by Targeting HMGB1

(2016) Xiuqin Wang et al.   INFLAMMATION

Extracellular vesicles — new tool for joint repair and regeneration

(2016) Jos Malda et al.   Nature Reviews Rheumatology

MicroRNAs: exploring new horizons in osteoarthritis

(2016) M. Nugent   OSTEOARTHRITIS AND CARTILAGE

What drives osteoarthritis?—synovialversussubchondral bone pathology

(2016) Thomas Hügle et al.   RHEUMATOLOGY

Mesenchymal Stem Cell Alterations in Bone Marrow Lesions in Patients With Hip Osteoarthritis

(2016) T. Mark Campbell et al.   Arthritis & Rheumatology

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

(2015) Yoshihiro Nakamura et al.   FEBS LETTERS

Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis

(2015) Hyeonkyeong Kim et al.   MOLECULES AND CELLS

DIANA-miRPath v3.0: deciphering microRNA function with experimental support

(2015) Ioannis S. Vlachos et al.   NUCLEIC ACIDS RESEARCH

Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use

(2015) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

Mesenchymal stem cell exosomes

(2015) Ruenn Chai Lai et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mesenchymal stem cells use extracellular vesicles to outsource mitophagy and shuttle microRNAs

(2015) Donald G. Phinney et al.   Nature Communications

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species

(2015) Serena Rubina Baglio et al.   Stem Cell Research & Therapy

The Role of Peripheral Nociceptive Neurons in the Pathophysiology of Osteoarthritis Pain

(2015) Rachel E. Miller et al.   Current Osteoporosis Reports

Chondrocyte and mesenchymal stem cell-based therapies for cartilage repair in osteoarthritis and related orthopaedic conditions

(2014) Ali Mobasheri et al.   MATURITAS

Osteoblast-Chondrocyte Interactions in Osteoarthritis

(2014) David M. Findlay et al.   Current Osteoporosis Reports

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

(2013) M A Karsdal et al.   ANNALS OF THE RHEUMATIC DISEASES

Paracrine Mechanisms of Mesenchymal Stem Cell-Based Therapy: Current Status and Perspectives

(2013) Xiaoting Liang et al.   CELL TRANSPLANTATION

Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis

(2013) Ashish Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes

(2013) Tetsuya Matsukawa et al.   ARTHRITIS RESEARCH & THERAPY

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration, and Invasion

(2012) Ning Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A microRNA signature associated with chondrogenic lineage commitment

(2012) BEHNAZ BAKHSHANDEH et al.   JOURNAL OF GENETICS

MicroRNA-199a-3p, microRNA-193b, and microRNA-320c are correlated to aging and regulate human cartilage metabolism

(2012) Taku Ukai et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

(2012) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Chondroclasts are mature osteoclasts which are capable of cartilage matrix resorption

(2012) H. J. Knowles et al.   VIRCHOWS ARCHIV

Patterns of compartment involvement in tibiofemoral osteoarthritis in men and women and in whites and African Americans

(2012) Barton L. Wise et al.   ARTHRITIS CARE & RESEARCH

Tissue engineering of functional articular cartilage: the current status

(2011) Linda Kock et al.   CELL AND TISSUE RESEARCH

Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs

(2010) Federica Collino et al.   PLoS One

Complexity of the microRNA repertoire revealed by next-generation sequencing

(2010) L. W. Lee et al.   RNA

miR-199a*, a Bone Morphogenic Protein 2-responsive MicroRNA, Regulates Chondrogenesis via Direct Targeting to Smad1

(2009) Edward A. Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-125b inhibits osteoblastic differentiation by down-regulation of cell proliferation

(2008) Yosuke Mizuno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS