Sinomenine Attenuates Cartilage Degeneration by Regulating miR-223-3p/NLRP3 Inflammasome Signaling

NLRP3 as a potentially novel biomarker for the management of osteoarthritis

(2018) M.J. McAllister et al.   OSTEOARTHRITIS AND CARTILAGE

MiR-223-3p overexpression inhibits cell proliferation and migration by regulating inflammation-associated cytokines in glioblastomas

(2018) Qiuping Ding et al.   PATHOLOGY RESEARCH AND PRACTICE

Icariin Activates Autophagy via Down-Regulation of the NF-κB Signaling-Mediated Apoptosis in Chondrocytes

(2018) Bobin Mi et al.   Frontiers in Pharmacology

Sinomenine protects against E.coli-induced acute lung injury in mice through Nrf2-NF-κB pathway

(2018) Suzi Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Acetazolamide protects rat articular chondrocytes from IL-1β-induced apoptosis by inhibiting the activation of NF-κB signal pathway

(2018) Li Cai et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis

(2018) Jinsoo Song et al.   Nature Communications

Cryptotanshinone protects against IL-1β-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice

(2017) Zhenhua Feng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Baicalin suppresses IL-1β-induced expression of inflammatory cytokines via blocking NF-κB in human osteoarthritis chondrocytes and shows protective effect in mice osteoarthritis models

(2017) Chunhui Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Curcumin Prevents Osteoarthritis by Inhibiting the Activation of Inflammasome NLRP3

(2017) Yufeng Sun et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Downregulation of miR-221-3p contributes to IL-1β-induced cartilage degradation by directly targeting the SDF1/CXCR4 signaling pathway

(2017) Xin Zheng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats

(2017) Weifeng Wang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

miRNA-1271 inhibits cell proliferation in neuroglioma by targeting fibronectin 1

(2017) Jian Gong et al.   Molecular Medicine Reports

Ly6G+ neutrophil-derived miR-223 inhibits the NLRP3 inflammasome in mitochondrial DAMP-induced acute lung injury

(2017) Zunyong Feng et al.   Cell Death & Disease

Revisiting the Role of Interleukin-1 Pathway in Osteoarthritis: Interleukin-1α and -1β, and NLRP3 Inflammasome Are Not Involved in the Pathological Features of the Murine Menisectomy Model of Osteoarthritis

(2017) Sonia Nasi et al.   Frontiers in Pharmacology

Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells

(2017) Chun Wang et al.   Scientific Reports

MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts

(2016) Dongze Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sinomenine enhances microglia M2 polarization and attenuates inflammatory injury in intracerebral hemorrhage

(2016) Hui Shi et al.   JOURNAL OF NEUROIMMUNOLOGY

The Overexpression of NALP3 Inflammasome in Knee Osteoarthritis Is Associated with Synovial Membrane Prolidase and NADPH Oxidase 2

(2016) Denise Clavijo-Cornejo et al.   Oxidative Medicine and Cellular Longevity

NLRP3 at the interface of metabolism and inflammation

(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage

(2015) Zhao Yang et al.   MOLECULAR IMMUNOLOGY

Eps8 regulates cellular proliferation and migration of breast cancer

(2014) CHENG CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

TLR4 signalling in osteoarthritis—finding targets for candidate DMOADs

(2014) Rodolfo Gómez et al.   Nature Reviews Rheumatology

Physiological and excessive mechanical compression of articular cartilage activates Smad2/3P signaling

(2014) W. Madej et al.   OSTEOARTHRITIS AND CARTILAGE

MAPK signaling mediates sinomenine hydrochloride-induced human breast cancer cell death via both reactive oxygen species-dependent and -independent pathways: an in vitro and in vivo study

(2014) X Li et al.   Cell Death & Disease

Histone deacetylase inhibitors increase microRNA-146a expression and enhance negative regulation of interleukin-1β signaling in osteoarthritis fibroblast-like synoviocytes

(2013) J.H. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models

(2012) Carole Bougault et al.   ARTHRITIS AND RHEUMATISM

NLRP3 Inflammasome Activity Is Negatively Controlled by miR-223

(2012) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Constitutively Activated NLRP3 Inflammasome Causes Inflammation and Abnormal Skeletal Development in Mice

(2012) Sheri L. Bonar et al.   PLoS One

Disease Modifying Osteoarthritis Drugs: Facing Development Challenges and Choosing Molecular Targets

(2010) Marie-Pierre Hellio Le Graverand-Gastineau   CURRENT DRUG TARGETS

Protective Effect of Sinomenine on Cartilage Degradation and Chondrocytes Apoptosis

(2010) Xiao-dong JU et al.   YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN