Mitochondrial Dysfunction and Diabetic Nephropathy: Nontraditional Therapeutic Opportunities

Astragaloside II Ameliorated Podocyte Injury and Mitochondrial Dysfunction in Streptozotocin-Induced Diabetic Rats

(2021) Jun Su et al.   Frontiers in Pharmacology

Interplay of adenosine monophosphate‐activated protein kinase/sirtuin‐1 activation and sodium influx inhibition mediates the renal benefits of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes: A novel conceptual framework

(2020) Milton Packer   DIABETES OBESITY & METABOLISM

CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM – 2020 EXECUTIVE SUMMARY

(2020) Alan J. Garber et al.   Endocrine Practice

Mitophagy in Acute Kidney Injury and Kidney Repair

(2020) Ying Wang et al.   Cells

Nepeta angustifolia C. Y. Wu improves renal injury in HFD/STZ-induced diabetic nephropathy and inhibits oxidative stress-induced apoptosis of mesangial cells

(2020) Shan Huang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Curcumin reverses diabetic nephropathy in streptozotocin-induced diabetes in rats by inhibition of PKCβ/p66Shc axis and activation of FOXO-3a

(2020) Jozaa Z. ALTamimi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Are low-carbohydrate diets safe in diabetic and nondiabetic chronic kidney disease?

(2019) Nia S. Mitchell et al.   Annals of the New York Academy of Sciences

Notoginsenoside R1 Protects db/db Mice against Diabetic Nephropathy via Upregulation of Nrf2-Mediated HO-1 Expression

(2019) Bin Zhang et al.   MOLECULES

Efficacy of Co-administration of Liuwei Dihuang Pills and Ginkgo Biloba Tablets on Albuminuria in Type 2 Diabetes: A 24-Month, Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial

(2019) Ruifeng Shi et al.   Frontiers in Endocrinology

Obacunone attenuates high glucose-induced oxidative damage in NRK-52E cells by inhibiting the activity of GSK-3β

(2019) Jie Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy

(2019) Sugandh Saxena et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy

(2019) Di Zhou et al.   Cell Death & Disease

Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy

(2019) Yongfang Wang et al.   Frontiers in Pharmacology

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Berberine protects against diabetic kidney disease via promoting PGC‐1α‐regulated mitochondrial energy homeostasis

(2019) Xin Qin et al.   BRITISH JOURNAL OF PHARMACOLOGY

AGE Content of a Protein Load Is Responsible for Renal Performances: A Pilot Study

(2018) Gabrielle Normand et al.   DIABETES CARE

Activation of GSK3β/β-TrCP axis via PHLPP1 exacerbates Nrf2 degradation leading to impairment in cell survival pathway during diabetic nephropathy

(2018) Alpana Mathur et al.   FREE RADICAL BIOLOGY AND MEDICINE

Incidence of end-stage renal disease following bariatric surgery in the Swedish Obese Subjects Study

(2018) A. Shulman et al.   INTERNATIONAL JOURNAL OF OBESITY

Impairment of PPARαand the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging

(2018) Ki Wung Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effect of Bariatric Surgery on CKD Risk

(2018) Allon N. Friedman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Update of pathophysiology and management of diabetic kidney disease

(2018) Yi-Chih Lin et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Mitochondrial dynamics in adaptive and maladaptive cellular stress responses

(2018) Verónica Eisner et al.   NATURE CELL BIOLOGY

Mitochondrial dysfunction in diabetic kidney disease

(2018) Josephine M. Forbes et al.   Nature Reviews Nephrology

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease

(2018) Szu-Yuan Li et al.   SEMINARS IN NEPHROLOGY

A Low-Protein Diet for Diabetic Kidney Disease: Its Effect and Molecular Mechanism, an Approach from Animal Studies

(2018) Munehiro Kitada et al.   Nutrients

Tangshen Formula Attenuates Diabetic Nephropathy by Promoting ABCA1-Mediated Renal Cholesterol Efflux in db/db Mice

(2018) Peng Liu et al.   Frontiers in Physiology

Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1α mediated attenuation of mitochondrial oxidative stress

(2018) Tao Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

5. Lifestyle Management: Standards of Medical Care in Diabetes—2019

(2018)   DIABETES CARE

Salidroside stimulates the Sirt1/PGC-1α axis and ameliorates diabetic nephropathy in mice

(2018) Haiyan Xue et al.   PHYTOMEDICINE

Nepeta angustifolia attenuates responses to vascular inflammation in high glucose-induced human umbilical vein endothelial cells through heme oxygenase-1 induction

(2018) Shan Huang et al.   JOURNAL OF ETHNOPHARMACOLOGY

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

(2017) Wen Li et al.   ENDOCRINOLOGY

High glucose repatterns human podocyte energy metabolism during differentiation and diabetic nephropathy

(2017) Toshiyuki Imasawa et al.   FASEB JOURNAL

Polydatin impairs mitochondria fitness and ameliorates podocyte injury by suppressing Drp1 expression

(2017) Zheng Ni et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PGC-1αProtects from Notch-Induced Kidney Fibrosis Development

(2017) Seung Hyeok Han et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Modeling glucose metabolism and lactate production in the kidney

(2017) Ying Chen et al.   MATHEMATICAL BIOSCIENCES

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Low-protein diet for the prevention of renal failure

(2017) Shaw WATANABE   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

The protective effect of betulinic acid (BA) diabetic nephropathy on streptozotocin (STZ)-induced diabetic rats

(2017) Rui Xie et al.   Food & Function

Diabetes-Induced Reactive Oxygen Species: Mechanism of Their Generation and Role in Renal Injury

(2017) Selim Fakhruddin et al.   Journal of Diabetes Research

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network

(2017) Xinhui Liu et al.   PLoS One

Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK/NF-κB pathway

(2016) Kang-feng Jiang et al.   ACTA PHARMACOLOGICA SINICA

UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness

(2016) Chitoku Toda et al.   CELL

The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated HypercholesterolemiaClinical Perspective

(2016) Mary E. Haas et al.   CIRCULATION

Mapping time-course mitochondrial adaptations in the kidney in experimental diabetes

(2016) M. T. Coughlan et al.   CLINICAL SCIENCE

Tapping into Mitochondria to Find Novel Targets for Diabetes Complications

(2016) Nicole B. Flemming et al.   CURRENT DRUG TARGETS

SGLT2 Inhibitors and the Diabetic Kidney

(2016) Paola Fioretto et al.   DIABETES CARE

Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy

(2016) B. A. Ayanga et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Resveratrol increases AdipoR1 and AdipoR2 expression in type 2 diabetic nephropathy

(2016) Hoon Suk Park et al.   Journal of Translational Medicine

Renal Function and Remission of Hypertension After Bariatric Surgery: a 5-Year Prospective Cohort Study

(2016) Karl J. Neff et al.   OBESITY SURGERY

Role of low protein diet in management of different stages of chronic kidney disease - practical aspects

(2016) Bharat V. Shah et al.   BMC Nephrology

Low-Protein Diets in Diabetic Chronic Kidney Disease (CKD) Patients: Are They Feasible and Worth the Effort?

(2016) Giorgina Piccoli et al.   Nutrients

PGC-1α overexpression protects against aldosterone-induced podocyte depletion: role of mitochondria

(2016) Min Zhao et al.   Oncotarget

Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice

(2016) Kristoffer Svensson et al.   PLoS One

Effects of Bariatric Surgery on Renal Function in Obese Patients: A Systematic Review and Meta Analysis

(2016) Kun Li et al.   PLoS One

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway

(2016) Chunling Huang et al.   Scientific Reports

The protective effects of beta-carotene against ischemia/reperfusion injury in rat ovarian tissue

(2015) Selina Aksak Karamese et al.   ACTA HISTOCHEMICA

Maintaining Ancient Organelles: Mitochondrial Biogenesis and Maturation

(2015) R. B. Vega et al.   CIRCULATION RESEARCH

Is Bariatric Surgery an Effective Treatment for Type II Diabetic Kidney Disease?

(2015) A. N. Friedman et al.   Clinical Journal of the American Society of Nephrology

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Leisure-time physical activity and development and progression of diabetic nephropathy in type 1 diabetes: the FinnDiane Study

(2015) Johan Wadén et al.   DIABETOLOGIA

Oleanolic acid andN-acetylcysteine ameliorate diabetic nephropathy through reduction of oxidative stress and endoplasmic reticulum stress in a type 2 diabetic rat model

(2015) Eun Soo Lee et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Chronic Running Exercise Alleviates Early Progression of Nephropathy with Upregulation of Nitric Oxide Synthases and Suppression of Glycation in Zucker Diabetic Rats

(2015) Daisuke Ito et al.   PLoS One

New Insights Into Molecular Mechanisms of Diabetic Kidney Disease

(2014) Shawn S. Badal et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Mitochondrial function and mitochondrial DNA maintenance with advancing age

(2014) Azhub I. Gaziev et al.   BIOGERONTOLOGY

The Glomerulus: The Sphere of Influence

(2014) M. R. Pollak et al.   Clinical Journal of the American Society of Nephrology

IHG-1 Increases Mitochondrial Fusion and Bioenergetic Function

(2014) F. B. Hickey et al.   DIABETES

The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells

(2014) Sean David Hughes et al.   JOURNAL OF NEUROCHEMISTRY

The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

(2014) Y. C. Wong et al.   JOURNAL OF NEUROSCIENCE

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion

(2013) Roberto Teruya et al.   Acta Cirurgica Brasileira

Effects of Zishentongluo in Patients with Early-Stage Diabetic Nephropathy

(2013) Jianwei Ma et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

(2013) G C Higgins et al.   BRITISH JOURNAL OF PHARMACOLOGY

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

(2013) Laura L. Dugan et al.   JOURNAL OF CLINICAL INVESTIGATION

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

(2013) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Effects of weight loss on renal function in obese CKD patients: a systematic review

(2013) Davide Bolignano et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Role of Exercise in the Management of Diabetes Mellitus: the Global Scenario

(2013) Zar Chi Thent et al.   PLoS One

Bariatric surgery versus non-surgical treatment for obesity: a systematic review and meta-analysis of randomised controlled trials

(2013) V. L. Gloy et al.   BMJ-British Medical Journal

Recent advances into the understanding of mitochondrial fission

(2012) Kirstin Elgass et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Mitochondria and Mitophagy

(2012) Dieter A. Kubli et al.   CIRCULATION RESEARCH

Bariatric Surgery Does Not Exacerbate and May Be Beneficial for the Microvascular Complications of Type 2 Diabetes

(2012) A. D. Miras et al.   DIABETES CARE

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

Glomerular hyperfiltration: definitions, mechanisms and clinical implications

(2012) Imed Helal et al.   Nature Reviews Nephrology

Management of Obesity-Induced Kidney Disease: A Critical Review of the Literature

(2012) Dimitrios N. Kiortsis et al.   Obesity Facts

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties

(2011) Edite Teixeira-Lemos et al.   Cardiovascular Diabetology

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway

(2011) M. Kitada et al.   DIABETES

AMPK Mediates the Initiation of Kidney Disease Induced by a High-Fat Diet

(2011) A.-E. Decleves et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: Effects of exercise and aging

(2009) Vladimir Ljubicic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Regulation and pharmacology of the mitochondrial permeability transition pore

(2009) D. B. Zorov et al.   CARDIOVASCULAR RESEARCH

Weight Loss Interventions in Chronic Kidney Disease: A Systematic Review and Meta-analysis

(2009) S. D. Navaneethan et al.   Clinical Journal of the American Society of Nephrology

Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications

(2009) J. E. Gerich   DIABETIC MEDICINE

Long-term effect of modification of dietary protein intake on the progression of diabetic nephropathy: a randomised controlled trial

(2009) D. Koya et al.   DIABETOLOGIA

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

(2008) J. M. Forbes et al.   DIABETES

Renal Alterations During Exercise

(2007) Guido Bellinghieri et al.   JOURNAL OF RENAL NUTRITION

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY