Interplay of adenosine monophosphate‐activated protein kinase/sirtuin‐1 activation and sodium influx inhibition mediates the renal benefits of sodium‐glucose co‐transporter‐2 inhibitors in type 2 diabetes: A novel conceptual framework

Novel tubular–glomerular interplay in diabetic kidney disease mediated by sirtuin 1, nicotinamide mononucleotide, and nicotinamide adenine dinucleotide Oshima Award Address 2017

(2019) Kazuhiro Hasegawa   Clinical and Experimental Nephrology

AMPK signalling: Implications for podocyte biology in diabetic nephropathy

(2019) Maria Szrejder et al.   BIOLOGY OF THE CELL

AMPK alleviates high uric acid-induced Na+-K+-ATPase signaling impairment and cell injury in renal tubules

(2019) Jing Xiao et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Proximal Tubule Autophagy Differs in Type 1 and 2 Diabetes

(2019) Shinsuke Sakai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

(2019) Vlado Perkovic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice

(2019) Masa-Ki Inoue et al.   Diabetology & Metabolic Syndrome

SGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis

(2019) Brendon L Neuen et al.   Lancet Diabetes & Endocrinology

Hypoxia-inducible factor-1α is the therapeutic target of the SGLT2 inhibitor for diabetic nephropathy

(2019) Ryoichi Bessho et al.   Scientific Reports

Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury

(2018) Quan Hong et al.   KIDNEY INTERNATIONAL

Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-κB pathway

(2018) Xu Chen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

High Basolateral Glucose Increases Sodium-Glucose Cotransporter 2 and Reduces Sirtuin-1 in Renal Tubules through Glucose Transporter-2 Detection

(2018) Hiroyuki Umino et al.   Scientific Reports

Effect of sodium-glucose cotransporter 2 inhibitor, empagliflozin, and α-glucosidase inhibitor, voglibose, on hepatic steatosis in an animal model of type 2 diabetes

(2018) Ji-Won Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases

(2017) Andrey V. Cybulsky   Nature Reviews Nephrology

Liraglutide and Renal Outcomes in Type 2 Diabetes

(2017) Johannes F.E. Mann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia inducible factor-1α mediates the profibrotic effect of albumin in renal tubular cells

(2017) Junping Hu et al.   Scientific Reports

Selective tubular activation of hypoxia-inducible factor-2α has dual effects on renal fibrosis

(2017) Kyoung Hye Kong et al.   Scientific Reports

Sodium Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus

(2016) Hiddo J.L. Heerspink et al.   CIRCULATION

HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice

(2016) Bijaya K. Nayak et al.   DIABETES

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels

(2016) Simon A. Hawley et al.   DIABETES

Effect of Saxagliptin on Renal Outcomes in the SAVOR-TIMI 53 Trial

(2016) Ofri Mosenzon et al.   DIABETES CARE

Hypoxia-inducible factor-1α promotes glomerulosclerosis and regulates COL1A2 expression through interactions with Smad3

(2016) Bethany Baumann et al.   KIDNEY INTERNATIONAL

Sirt1 and the Mitochondria

(2016)   MOLECULES AND CELLS

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

(2016) Christoph Wanner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy and Tubular Cell Death in the Kidney

(2016) Andrea Havasi et al.   SEMINARS IN NEPHROLOGY

β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy

(2016) J Liu et al.   Cell Death & Disease

Dapagliflozin, SGLT2 Inhibitor, Attenuates Renal Ischemia-Reperfusion Injury

(2016) Yoon-Kyung Chang et al.   PLoS One

Empagliflozin, an Inhibitor of Sodium-Glucose Cotransporter 2 Exerts Anti-Inflammatory and Antifibrotic Effects on Experimental Diabetic Nephropathy Partly by Suppressing AGEs-Receptor Axis

(2015) A. Ojima et al.   HORMONE AND METABOLIC RESEARCH

Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy

(2015) Wei Jing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of autophagy inducers in clinical medicine

(2015) Beth Levine et al.   JOURNAL OF CLINICAL INVESTIGATION

The renoprotective role of autophagy activation in proximal tubular epithelial cells in diabetic nephropathy

(2015) Ying Xu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation

(2015) Chunmei Chang et al.   MOLECULAR CELL

Hif-2α Promotes Degradation of Mammalian Peroxisomes by Selective Autophagy

(2014) Katharina M. Walter et al.   Cell Metabolism

Activation of Hypoxia-Inducible Factors Prevents Diabetic Nephropathy

(2014) L. Nordquist et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Functional Role of Glucose Metabolism, Osmotic Stress, and Sodium-Glucose Cotransporter Isoform-Mediated Transport on Na+/H+ Exchanger Isoform 3 Activity in the Renal Proximal Tubule

(2014) T. D. Pessoa et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in db/db Mice

(2014) Naoto Terami et al.   PLoS One

Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders

(2013) Anu Kauppinen et al.   CELLULAR SIGNALLING

Regulation of ion channels and transporters by AMP-activated kinase (AMPK)

(2013) Florian Lang et al.   Channels

Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus

(2013) David Z.I. Cherney et al.   CIRCULATION

Sodium-glucose cotransporter 2-mediated oxidative stress augments advanced glycation end products-induced tubular cell apoptosis

(2013) Sayaka Maeda et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

(2013) Laura L. Dugan et al.   JOURNAL OF CLINICAL INVESTIGATION

mVps34 Deletion in Podocytes Causes Glomerulosclerosis by Disrupting Intracellular Vesicle Trafficking

(2013) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Advanced Glycated End-Products Affect HIF-Transcriptional Activity in Renal Cells

(2013) Tzvetanka Bondeva et al.   MOLECULAR ENDOCRINOLOGY

Accelerated recovery of renal mitochondrial and tubule homeostasis with SIRT1/PGC-1α activation following ischemia–reperfusion injury

(2013) Jason A. Funk et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury

(2012) Shuya Liu et al.   Autophagy

Sirtuins and renal diseases: relationship with aging and diabetic nephropathy

(2012) Munehiro Kitada et al.   CLINICAL SCIENCE

The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling

(2012) Rui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The balance of beneficial and deleterious effects of hypoxia-inducible factor activation by prolyl hydroxylase inhibitor in rat remnant kidney depends on the timing of administration

(2012) Xiaofang Yu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Enhancement of Na/K pump activity by chronic intermittent hypobaric hypoxia protected against reperfusion injury

(2011) Hui-cai Guo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tubular Injury in a Rat Model of Type 2 Diabetes Is Prevented by Metformin

(2011) Yumi Takiyama et al.   DIABETES

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

(2011) Ken Inoki et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteomics analysis reveals diabetic kidney as a ketogenic organ in type 2 diabetes

(2010) Dongjuan Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Proinsulin C-peptide prevents type-1 diabetes-induced decrease of renal Na+-K+-ATPase α1-subunit in rats

(2010) Lina Nordquist et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function

(2010) Kazuhiro Hasegawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose-Induced Regulation of NHEs Activity and SGLTs Expression Involves the PKA Signaling Pathway

(2010) Olívia Beloto-Silva et al.   JOURNAL OF MEMBRANE BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In vivo stimulation of AMP-activated protein kinase enhanced tubuloglomerular feedback but reduced tubular sodium transport during high dietary NaCl intake

(2010) Dan Yang Huang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Therapeutic perspective: starting an angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker in a diabetic patient

(2010) Ghassan Jarred et al.   Therapeutic Advances in Endocrinology and Metabolism

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aberrant ENaC activation in Dahl salt-sensitive rats

(2009) Yutaka Kakizoe et al.   JOURNAL OF HYPERTENSION

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney

(2009) Y. R. Song et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Long-Term Treatment of Sirolimus but Not Cyclosporine Ameliorates Diabetic Nephropathy in the Rat

(2009) Sandra Wittmann et al.   TRANSPLANTATION

Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

(2008) Kazuhiro Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS