Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol

(2018) Shiori Sekine et al.   BMC BIOLOGY

Activation of GSK3β/β-TrCP axis via PHLPP1 exacerbates Nrf2 degradation leading to impairment in cell survival pathway during diabetic nephropathy

(2018) Alpana Mathur et al.   FREE RADICAL BIOLOGY AND MEDICINE

Berberine induced modulation of PHLPP2-Akt-MST1 kinase signaling is coupled with mitochondrial impairment and hepatoma cell death

(2018) Sugandh Saxena et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ipragliflozin improves mitochondrial abnormalities in renal tubules induced by a high-fat diet

(2018) Susumu Takagi et al.   Journal of Diabetes Investigation

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

(2017) Wen Li et al.   ENDOCRINOLOGY

High glucose repatterns human podocyte energy metabolism during differentiation and diabetic nephropathy

(2017) Toshiyuki Imasawa et al.   FASEB JOURNAL

Linking mitochondrial dysfunction to neurodegeneration in lysosomal storage diseases

(2017) Afshin Saffari et al.   JOURNAL OF INHERITED METABOLIC DISEASE

H2O2 induces caveolin-1 degradation and impaired mitochondrial function in E11 podocytes

(2017) Ya-Hui Chen et al.   Molecular Medicine Reports

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

(2017) Weier Qi et al.   NATURE MEDICINE

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

A novel pan-Nox inhibitor, APX-115, protects kidney injury in streptozotocin-induced diabetic mice: possible role of peroxisomal and mitochondrial biogenesis

(2017) Guideock Kwon et al.   Oncotarget

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network

(2017) Xinhui Liu et al.   PLoS One

Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells

(2016) Xiaocui Jiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bioenergetic roles of mitochondrial fusion

(2016) Eduardo Silva Ramos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility

(2016) Haiying Qi et al.   DIABETES

SGLT2 Inhibitors and the Diabetic Kidney

(2016) Paola Fioretto et al.   DIABETES CARE

A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity

(2016) Munehiro Kitada et al.   DIABETOLOGIA

Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission

(2016) Laura D. Osellame et al.   JOURNAL OF CELL SCIENCE

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy

(2016) Jianyin Long et al.   JOURNAL OF CLINICAL INVESTIGATION

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

(2016) Christoph Wanner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondria–Power Players in Kidney Function?

(2016) Josephine M. Forbes   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inhibition of autophagy increased AGE/ROS-mediated apoptosis in mesangial cells

(2016) Li Xu et al.   Cell Death & Disease

Hyperglycemia induced damage to mitochondrial respiration in renal mesangial and tubular cells: Implications for diabetic nephropathy

(2016) Anna Czajka et al.   Redox Biology

The Incidence of End-Stage Renal Disease in the Diabetic (Compared to the Non-Diabetic) Population: A Systematic Review

(2016) Maria Narres et al.   PLoS One

Thioredoxin interacting protein (TXNIP) regulates tubular autophagy and mitophagy in diabetic nephropathy through the mTOR signaling pathway

(2016) Chunling Huang et al.   Scientific Reports

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

(2015) Olivia Lenoir et al.   Autophagy

Selective removal of mitochondria via mitophagy: distinct pathways for different mitochondrial stresses

(2015) Huifang Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

The Opa1-Dependent Mitochondrial Cristae Remodeling Pathway Controls Atrophic, Apoptotic, and Ischemic Tissue Damage

(2015) Tatiana Varanita et al.   Cell Metabolism

Mitochondrial Hormesis and Diabetic Complications: Figure 1

(2015) Kumar Sharma   DIABETES

Thioredoxin-Interacting Protein Deficiency Protects against Diabetic Nephropathy

(2015) A. Shah et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes

(2015) Gina Manda et al.   MEDIATORS OF INFLAMMATION

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition to DRP1 translocation can mitigate p38 MAPK-signaling pathway activation in GMC induced by hyperglycemia

(2015) LieMei Zhang et al.   RENAL FAILURE

Palmitate induces ER calcium depletion and apoptosis in mouse podocytes subsequent to mitochondrial oxidative stress

(2015) S Xu et al.   Cell Death & Disease

A new Classification of Diabetic Nephropathy 2014: a report from Joint Committee on Diabetic Nephropathy

(2015) Masakazu Haneda et al.   Journal of Diabetes Investigation

Non-proteinuric pathways in loss of renal function in patients with type 2 diabetes

(2015) Esteban Porrini et al.   Lancet Diabetes & Endocrinology

Altered Mitochondrial Function, Mitochondrial DNA and Reduced Metabolic Flexibility in Patients With Diabetic Nephropathy

(2015) Anna Czajka et al.   EBioMedicine

Mitochondrial Glutathione in Diabetic Nephropathy

(2015) Lawrence Lash   Journal of Clinical Medicine

Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy

(2015) Shinji Kume et al.   Diabetes & Metabolism Journal

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

The Glomerulus: The Sphere of Influence

(2014) M. R. Pollak et al.   Clinical Journal of the American Society of Nephrology

Collecting Duct Principal Cell Transport Processes and Their Regulation

(2014) D. Pearce et al.   Clinical Journal of the American Society of Nephrology

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Disruption of Renal Tubular Mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic Kidney Disease

(2014) M. Zhan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission

(2014) Patrick J. Macdonald et al.   MOLECULAR BIOLOGY OF THE CELL

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Mechanisms and biological functions of autophagy in diseased and ageing kidneys

(2014) Sophie Fougeray et al.   Nature Reviews Nephrology

Specific Interaction with Cardiolipin Triggers Functional Activation of Dynamin-Related Protein 1

(2014) Itsasne Bustillo-Zabalbeitia et al.   PLoS One

Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy

(2014) Shinji Kume et al.   Biomed Research International

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

(2013) G C Higgins et al.   BRITISH JOURNAL OF PHARMACOLOGY

NADPH Oxidases, Reactive Oxygen Species, and the Kidney: Friend and Foe

(2013) M. Sedeek et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

(2013) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology

(2013) Ming Zhan et al.   KIDNEY INTERNATIONAL

Rheb and mammalian target of rapamycin in mitochondrial homoeostasis

(2013) M. J. Groenewoud et al.   Open Biology

Sites of reactive oxygen species generation by mitochondria oxidizing different substrates

(2013) Casey L. Quinlan et al.   Redox Biology

Emerging role of autophagy in kidney function, diseases and aging

(2012) Tobias B. Huber et al.   Autophagy

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Autophagy in proximal tubules protects against acute kidney injury

(2012) Man Jiang et al.   KIDNEY INTERNATIONAL

The proximal tubule in the pathophysiology of the diabetic kidney

(2011) Volker Vallon   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AMPK-Dependent Phosphorylation of ULK1 Induces Autophagy

(2011) Mantong Zhao et al.   Cell Metabolism

Therapeutic Modalities in Diabetic Nephropathy: Standard and Emerging Approaches

(2011) Emaad M. Abdel-Rahman et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Glucose handling by the kidney

(2011) Amanda Mather et al.   KIDNEY INTERNATIONAL

Chronic high glucose downregulates mitochondrial calpain 10 and contributes to renal cell death and diabetes-induced renal injury

(2011) Marisa D. Covington et al.   KIDNEY INTERNATIONAL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Tubulointerstitial injury and the progression of chronic kidney disease

(2011) Kavita S. Hodgkins et al.   PEDIATRIC NEPHROLOGY

Specific metabolic rates of major organs and tissues across adulthood: evaluation by mechanistic model of resting energy expenditure

(2010) ZiMian Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Autophagy Is a Renoprotective Mechanism During in Vitro Hypoxia and in Vivo Ischemia-Reperfusion Injury

(2010) Man Jiang et al.   AMERICAN JOURNAL OF PATHOLOGY

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

The sites and topology of mitochondrial superoxide production

(2010) Martin D. Brand   EXPERIMENTAL GERONTOLOGY

Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases

(2010) Shruti Singh et al.   FREE RADICAL RESEARCH

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expression, Localization, and Function of the Thioredoxin System in Diabetic Nephropathy

(2009) A. Advani et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA