The Unifying Hypothesis of Alzheimer’s Disease: Heparan Sulfate Proteoglycans/Glycosaminoglycans Are Key as First Hypothesized Over 30 Years Ago

SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis

(2021) Miguel Portillo et al.   Cell Reports

Sulfation of Glycosaminoglycans Modulates the Cell Cycle of Embryonic Mouse Spinal Cord Neural Stem Cells

(2021) Elena Schaberg et al.   Frontiers in Cell and Developmental Biology

The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease

(2020) Antonio Monaco et al.   MOLECULAR THERAPY

Heparan Sulfate Proteoglycans Undergo Differential Expression Alterations in Alzheimer Disease Brains

(2020) Laura Lorente-Gea et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

SARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

(2020) Thomas Mandel Clausen et al.   CELL

Heparin-binding Peptides as Novel Therapies to Stop SARS-CoV-2 Cellular Entry and Infection

(2020) Omid Tavassoly et al.   MOLECULAR PHARMACOLOGY

Glycosaminoglycans from Alzheimer’s disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau

(2019) Minh Bao Huynh et al.   PLoS One

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

(2019) Joseph F. Arboleda-Velasquez et al.   NATURE MEDICINE

Tau-Cofactor Complexes as Building Blocks of Tau Fibrils

(2019) Yann Fichou et al.   Frontiers in Neuroscience

Specific glycosaminoglycan chain length and sulfation patterns are required for cell uptake of tauversusα-synuclein and β-amyloid aggregates

(2018) Barbara E. Stopschinski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Proteoglycans as Relays of Neuroinflammation

(2018) Paul O’Callaghan et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Glycomic and Proteomic changes in aging brain nigrostriatal pathway

(2018) Rekha Raghunathan et al.   MOLECULAR & CELLULAR PROTEOMICS

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease

(2018) Raffaella Nativio et al.   NATURE NEUROSCIENCE

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

(2018) William A. Eimer et al.   NEURON

Human Neurospheroid Arrays for In Vitro Studies of Alzheimer’s Disease

(2018) Mehdi Jorfi et al.   Scientific Reports

Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity

(2018) Giuseppe Condomitti et al.   Frontiers in Molecular Neuroscience

Anatomical changes and pathophysiology of the brain in mucopolysaccharidosis disorders

(2018) Brian W. Bigger et al.   MOLECULAR GENETICS AND METABOLISM

Heparan sulfate is an important mediator of Ebola virus infection in polarized epithelial cells

(2018) Manasi Tamhankar et al.   Virology Journal

Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs)

(2018) Jennifer N. Rauch et al.   Scientific Reports

The antimicrobial protection hypothesis of Alzheimer's disease

(2018) Robert D. Moir et al.   Alzheimers & Dementia

Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis

(2018) Hongmei Li et al.   Translational Neurodegeneration

Axonal dystrophy in the brain of mice with Sanfilippo syndrome

(2017) Helen Beard et al.   EXPERIMENTAL NEUROLOGY

Upregulated Expression of Heparanase and Heparanase 2 in the Brains of Alzheimer’s Disease

(2017) Beatriz García et al.   JOURNAL OF ALZHEIMERS DISEASE

Heparan sulfate as a receptor for poxvirus infections and as a target for antiviral agents

(2017) Mayank Khanna et al.   JOURNAL OF GENERAL VIROLOGY

Heparan sulfate alterations in extracellular matrix structures and fibroblast growth factor-2 signaling impairment in the aged neurogenic niche

(2017) Taihei Yamada et al.   JOURNAL OF NEUROCHEMISTRY

Heparan Sulfate Proteoglycan Is an Important Attachment Factor for Cell Entry of Akabane and Schmallenberg Viruses

(2017) Shin Murakami et al.   JOURNAL OF VIROLOGY

Developmental and behavioral aspects of mucopolysaccharidoses with brain manifestations — Neurological signs and symptoms

(2017) Elsa G. Shapiro et al.   MOLECULAR GENETICS AND METABOLISM

How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans

(2017) Alan Cartmell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clearance of Heparan Sulfate and Attenuation of CNS Pathology by Intracerebroventricular BMN 250 in Sanfilippo Type B Mice

(2017) Mika Aoyagi-Scharber et al.   Molecular Therapy-Methods & Clinical Development

The D-form of a novel heparan binding peptide decreases cytomegalovirus infection in vivo and in vitro

(2016) Elisabeth A. Pitt et al.   ANTIVIRAL RESEARCH

Basic chemokine-derived glycosaminoglycan binding peptides exert antiviral properties against dengue virus serotype 2, herpes simplex virus-1 and respiratory syncytial virus

(2016) Vincent Vanheule et al.   BIOCHEMICAL PHARMACOLOGY

Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

(2016) Yuan Fu et al.   Molecular Neurodegeneration

Braak staging, plaque pathology, and APOE status in elderly persons without cognitive impairment

(2016) Elliott J. Mufson et al.   NEUROBIOLOGY OF AGING

Neuronal heparan sulfates promote amyloid pathology by modulating brain amyloid-β clearance and aggregation in Alzheimer’s disease

(2016) Chia-Chen Liu et al.   Science Translational Medicine

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Surface Proteoglycans as Mediators in Bacterial Pathogens Infections

(2016) Beatriz García et al.   Frontiers in Microbiology

Lysosomal storage of heparan sulfate causes mitochondrial defects, altered autophagy, and neuronal death in the mouse model of mucopolysaccharidosis III type C

(2015) Alexey V. Pshezhetsky   Autophagy

Neuronal cell cycle: the neuron itself and its circumstances

(2015) José M Frade et al.   CELL CYCLE

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Heparanase is a host enzyme required for herpes simplex virus-1 release from cells

(2015) Satvik R. Hadigal et al.   Nature Communications

Characterization of Glycosaminoglycan (GAG) Sulfatases from the Human Gut SymbiontBacteroides thetaiotaomicronReveals the First GAG-specific Bacterial Endosulfatase

(2014) Jonathan E. Ulmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implications of heparan sulfate and heparanase in neuroinflammation

(2014) Xiao Zhang et al.   MATRIX BIOLOGY

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Heparanase in inflammation and inflammation-associated cancer

(2013) Amichay Meirovitz et al.   FEBS Journal

Soluble amyloid-  precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans

(2013) C. Reinhard et al.   JOURNAL OF CELL SCIENCE

Amyloid-  signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease

(2013) M. E. Seward et al.   JOURNAL OF CELL SCIENCE

Heparan sulfate in the nucleus and its control of cellular functions

(2013) Mark D. Stewart et al.   MATRIX BIOLOGY

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Immunodeficiency Virus and Heparan Sulfate: From Attachment to Entry Inhibition

(2013) Bridgette J. Connell et al.   Frontiers in Immunology

Heparan Sulfate Subdomains that are Degraded by Sulf Accumulate in Cerebral Amyloid ß Plaques of Alzheimer's Disease

(2012) Tomomi Hosono-Fukao et al.   AMERICAN JOURNAL OF PATHOLOGY

Glycosaminoglycan Binding Facilitates Entry of a Bacterial Pathogen into Central Nervous Systems

(2011) Yung-Chi Chang et al.   PLoS Pathogens

Quantitative Characterization of Heparin Binding to Tau Protein

(2009) Hai-Li Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparanase Regulates Levels of Syndecan-1 in the Nucleus

(2009) Ligong Chen et al.   PLoS One

Syndecan-1 and FGF-2, but Not FGF Receptor-1, Share a Common Transport Route and Co-Localize with Heparanase in the Nuclei of Mesenchymal Tumor Cells

(2009) Fang Zong et al.   PLoS One

Role of the N- and C-Terminal Domains in Binding of Apolipoprotein E Isoforms to Heparan Sulfate and Dermatan Sulfate: A Surface Plasmon Resonance Study†

(2008) Yuko Yamauchi et al.   BIOCHEMISTRY

The importance of heparan sulfate in herpesvirus infection

(2008) Christopher D. O’Donnell et al.   VIROLOGICA SINICA