Structure‐guided envelope trimer design in HIV‐1 vaccine development: a narrative review

Virus vaccines: proteins prefer prolines

(2021) Rogier W. Sanders et al.   Cell Host & Microbe

The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection

(2021) Tysheena P. Charles et al.   PLoS Pathogens

Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition

(2021) Lawrence Corey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike

(2021) Ronald Derking et al.   Cell Reports

Current approaches to HIV vaccine development: a narrative review

(2021) Jiae Kim et al.   Journal of the International AIDS Society

Strategies for induction of HIV‐1 envelope‐reactive broadly neutralizing antibodies

(2021) Wilton B. Williams et al.   Journal of the International AIDS Society

Autologous neutralizing antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits

(2020) Yuhe R. Yang et al.   JOURNAL OF VIROLOGY

Networks of HIV-1 Envelope Glycans Maintain Antibody Epitopes in the Face of Glycan Additions and Deletions

(2020) Gemma E. Seabright et al.   STRUCTURE

Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers

(2020) Lucy Rutten et al.   Cell Reports

Mapping Polyclonal Antibody Responses in Non-human Primates Vaccinated with HIV Env Trimer Subunit Vaccines

(2020) Bartek Nogal et al.   Cell Reports

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

(2020) Ching-Lin Hsieh et al.   SCIENCE

Neutralizing antibody responses induced by HIV-1 envelope glycoprotein SOSIP trimers derived from elite neutralizers

(2020) Anna Schorcht et al.   JOURNAL OF VIROLOGY

SARS-CoV-2 vaccines in development

(2020) Florian Krammer   NATURE

Visualization of the HIV-1 Env glycan shield across scales

(2020) Zachary T. Berndsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

(2020) Christopher A. Cottrell et al.   PLoS Pathogens

Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein

(2020) Lorenzo Casalino et al.   ACS Central Science

Glycan positioning impacts HIV-1 Env glycan-shield density, function, and recognition by antibodies

(2020) Qing Wei et al.   iScience

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

(2020) Ryan S. Roark et al.   SCIENCE

Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

(2019) Alexandra C. Walls et al.   CELL

Structure-Based Vaccine Antigen Design

(2019) Barney S. Graham et al.   Annual Review of Medicine

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

(2019) Kimberly M. Cirelli et al.   CELL

Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope

(2019) Till Schoofs et al.   IMMUNITY

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques

(2019) Amelia Escolano et al.   NATURE

The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization

(2019) Lin Lei et al.   Cell Reports

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

(2019) Kwinten Sliepen et al.   Nature Communications

Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms

(2019) Philip J.M. Brouwer et al.   Current Opinion in HIV and AIDS

Nanoparticle Vaccines for Inducing HIV-1 Neutralizing Antibodies

(2019) Mitch Brinkkemper et al.   Vaccines

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

(2019) Viktoriya Dubrovskaya et al.   IMMUNITY

A Neutralizing Antibody Recognizing Primarily N -Linked Glycan Targets the Silent Face of the HIV Envelope

(2018) Tongqing Zhou et al.   IMMUNITY

HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure

(2018) Peter D. Kwong et al.   IMMUNITY

Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination

(2018) Alba Torrents de la Peña et al.   JOURNAL OF VIROLOGY

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

(2018) Kai Xu et al.   NATURE MEDICINE

A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers

(2018) Lucy Rutten et al.   Cell Reports

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques

(2018) P. J. Klasse et al.   PLoS Pathogens

Cleavage-Independent HIV-1 Trimers From CHO Cell Lines Elicit Robust Autologous Tier 2 Neutralizing Antibodies

(2018) Shridhar Bale et al.   Frontiers in Immunology

DEER Spectroscopy Measurements Reveal Multiple Conformations of HIV-1 SOSIP Envelopes that Show Similarities with Envelopes on Native Virions

(2018) Beth M. Stadtmueller et al.   IMMUNITY

Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies

(2018) Hongying Duan et al.   IMMUNITY

Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization

(2018) Matteo Bianchi et al.   IMMUNITY

Stabilizing HIV-1 envelope glycoprotein trimers to induce neutralizing antibodies

(2018) Alba Torrents de la Peña et al.   Retrovirology

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer

(2018) Liwei Cao et al.   Nature Communications

Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen

(2018) Weston B. Struwe et al.   Cell Reports

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

(2018) Yoann Aldon et al.   Cell Reports

Closing and opening holes in the glycan shield of HIV-1 envelope glycoprotein SOSIP trimers can redirect the neutralizing antibody response to the newly unmasked epitopes

(2018) Rajesh P. Ringe et al.   JOURNAL OF VIROLOGY

Recent progress in broadly neutralizing antibodies to HIV

(2018) Devin Sok et al.   NATURE IMMUNOLOGY

HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth

(2018) Jelle van Schooten et al.   Retrovirology

Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

(2018) Kshitij Wagh et al.   Cell Reports

HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

(2018) Celia C. LaBranche et al.   PLoS Pathogens

Glycosylation profiling to evaluate glycoprotein immunogens against HIV-1

(2017) Anna-Janina Behrens et al.   Expert Review of Proteomics

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

(2017) Jeong Hyun Lee et al.   IMMUNITY

Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach

(2017) Paola Martinez-Murillo et al.   IMMUNITY

Glycine Substitution at Helix-to-Coil Transitions Facilitates the Structural Determination of a Stabilized Subtype C HIV Envelope Glycoprotein

(2017) Javier Guenaga et al.   IMMUNITY

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

(2017) Matthias Pauthner et al.   IMMUNITY

Genetic and structural analyses of affinity maturation in the humoral response to HIV-1

(2017) Thomas B. Kepler et al.   IMMUNOLOGICAL REVIEWS

Characterization of a stable HIV-1 B/C recombinant, soluble, and trimeric envelope glycoprotein (Env) highly resistant to CD4-induced conformational changes

(2017) Rajesh Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers

(2017) Steven W. de Taeye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

(2017) Max Medina-Ramírez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

(2017) Gwo-Yu Chuang et al.   JOURNAL OF VIROLOGY

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

(2017) Jesper Pallesen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for antibody-mediated neutralization of Lassa virus

(2017) Kathryn M. Hastie et al.   SCIENCE

Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding

(2017) Daniel W. Kulp et al.   Nature Communications

Stabilized HIV-1 envelope glycoprotein trimers for vaccine use

(2017) Max Medina-Ramírez et al.   Current Opinion in HIV and AIDS

Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization

(2017) Alba Torrents de la Peña et al.   Cell Reports

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

(2017) Tongqing Zhou et al.   Cell Reports

Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response

(2017) Viktoriya Dubrovskaya et al.   PLoS Pathogens

Broadly Neutralizing Antibodies to HIV and Their Role in Vaccine Design

(2016) Dennis R. Burton et al.   Annual Review of Immunology

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

(2016) Amelia Escolano et al.   CELL

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

(2016) Jon M. Steichen et al.   IMMUNITY

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

(2016) Rino Rappuoli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Optimal immunization cocktails can promote induction of broadly neutralizing Abs against highly mutable pathogens

(2016) J. Scott Shaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer

(2016) J. H. Lee et al.   SCIENCE

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen

(2016) J. G. Jardine et al.   SCIENCE

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

(2016) R. Kong et al.   SCIENCE

HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies

(2016) Steven W. de Taeye et al.   TRENDS IN IMMUNOLOGY

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

(2016) Laura E. McCoy et al.   Cell Reports

Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort

(2016) Elise Landais et al.   PLoS Pathogens

An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability

(2016) Marit J. van Gils et al.   Nature Microbiology

Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes

(2015) Steven W. de Taeye et al.   CELL

Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

(2015) Shenshen Wang et al.   CELL

HIV-1 Fitness Cost Associated with Escape from the VRC01 Class of CD4 Binding Site Neutralizing Antibodies

(2015) Rebecca M. Lynch et al.   JOURNAL OF VIROLOGY

Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers

(2015) Rajesh P. Ringe et al.   JOURNAL OF VIROLOGY

A Native-Like SOSIP.664 Trimer Based on an HIV-1 Subtype BenvGene

(2015) Pavel Pugach et al.   JOURNAL OF VIROLOGY

Structure-Guided Redesign Increases the Propensity of HIV Env To Generate Highly Stable Soluble Trimers

(2015) Javier Guenaga et al.   JOURNAL OF VIROLOGY

Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity

(2015) Joyce K. Hu et al.   JOURNAL OF VIROLOGY

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env

(2015) Ivelin S. Georgiev et al.   JOURNAL OF VIROLOGY

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

(2015) Young Do Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens

(2015) Jean-Philippe Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 neutralizing antibodies induced by native-like envelope trimers

(2015) R. W. Sanders et al.   SCIENCE

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

(2015) Young Do Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design

(2015) Shailendra Kumar Sharma et al.   Cell Reports

Comprehensive Antigenic Map of a Cleaved Soluble HIV-1 Envelope Trimer

(2015) Ronald Derking et al.   PLoS Pathogens

Well-Ordered Trimeric HIV-1 Subtype B and C Soluble Spike Mimetics Generated by Negative Selection Display Native-like Properties

(2015) Javier Guenaga et al.   PLoS Pathogens

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques

(2014) Masashi Shingai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Simulation of B Cell Affinity Maturation Explains Enhanced Antibody Cross-Reactivity Induced by the Polyvalent Malaria Vaccine AMA1

(2014) Sidhartha Chaudhury et al.   JOURNAL OF IMMUNOLOGY

Structure and immune recognition of trimeric pre-fusion HIV-1 Env

(2014) Marie Pancera et al.   NATURE

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

(2014) J. B. Munro et al.   SCIENCE

CD4-Induced Activation in a Soluble HIV-1 Env Trimer

(2014) Miklos Guttman et al.   STRUCTURE

Identification of an HIV-1 Clade A Envelope That Exhibits Broad Antigenicity and Neutralization Sensitivity and Elicits Antibodies Targeting Three Distinct Epitopes

(2013) S. Hoffenberg et al.   JOURNAL OF VIROLOGY

Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9

(2013) Jean-Philippe Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

(2013) J. S. McLellan et al.   SCIENCE

Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

(2013) J.-P. Julien et al.   SCIENCE

Cryo-EM Structure of a Fully Glycosylated Soluble Cleaved HIV-1 Envelope Trimer

(2013) D. Lyumkis et al.   SCIENCE

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

A Short Segment of the HIV-1 gp120 V1/V2 Region Is a Major Determinant of Resistance to V1/V2 Neutralizing Antibodies

(2012) N. A. Doria-Rose et al.   JOURNAL OF VIROLOGY

Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

(2012) B. Moldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Complex Carbohydrates in Human Immunodeficiency Virus Type 1 Infection and Resistance to Antibody Neutralization

(2010) J. M. Binley et al.   JOURNAL OF VIROLOGY

Prevalence of cross-reactive HIV-1-neutralizing activity in HIV-1-infected patients with rapid or slow disease progression

(2009) Marit J van Gils et al.   AIDS

Generation of stable monoclonal antibody–producing B cell receptor–positive human memory B cells by genetic programming

(2009) Mark J Kwakkenbos et al.   NATURE MEDICINE

Broadly Neutralizing Human Anti-HIV Antibody 2G12 Is Effective in Protection against Mucosal SHIV Challenge Even at Low Serum Neutralizing Titers

(2009) Ann J. Hessell et al.   PLoS Pathogens

The Challenge of HIV-1 Subtype Diversity

(2008) Barbara S. Taylor et al.   NEW ENGLAND JOURNAL OF MEDICINE