Nanoparticle Vaccines for Inducing HIV-1 Neutralizing Antibodies

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

(2019) Masaru Kanekiyo et al.   NATURE IMMUNOLOGY

Immunological basis for enhanced immunity of nanoparticle vaccines

(2019) Hannah G Kelly et al.   Expert Review of Vaccines

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

(2019) Jessica Marcandalli et al.   CELL

A nanoparticle-based HCV vaccine with enhanced potency

(2019) Yu Yan et al.   JOURNAL OF INFECTIOUS DISEASES

Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques

(2019) Amelia Escolano et al.   NATURE

An ultra-stable gold-coordinated protein cage displaying reversible assembly

(2019) Ali D. Malay et al.   NATURE

The HIV-1 Envelope Glycoprotein C3/V4 Region Defines a Prevalent Neutralization Epitope following Immunization

(2019) Lin Lei et al.   Cell Reports

Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence

(2019) Kwinten Sliepen et al.   Nature Communications

Presentation of HIV-1 envelope glycoprotein trimers on diverse nanoparticle platforms

(2019) Philip J.M. Brouwer et al.   Current Opinion in HIV and AIDS

Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates

(2019) Joseph R. Francica et al.   PLOS BIOLOGY

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

(2018) Robert K. Abbott et al.   IMMUNITY

The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen

(2018) Colin Havenar-Daughton et al.   Science Translational Medicine

Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques

(2018) P. J. Klasse et al.   PLoS Pathogens

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens

(2018) Ivelin S. Georgiev et al.   ACS Infectious Diseases

Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization

(2018) Matteo Bianchi et al.   IMMUNITY

Recent progress in broadly neutralizing antibodies to HIV

(2018) Devin Sok et al.   NATURE IMMUNOLOGY

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

(2018) Talar Tokatlian et al.   SCIENCE

Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes

(2018) Talar Tokatlian et al.   Scientific Reports

HIV-1 vaccine design through minimizing envelope metastability

(2018) Linling He et al.   Science Advances

Particulate Array of Well-Ordered HIV Clade C Env Trimers Elicits Neutralizing Antibodies that Display a Unique V2 Cap Approach

(2017) Paola Martinez-Murillo et al.   IMMUNITY

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

(2017) Matthias Pauthner et al.   IMMUNITY

Native-like Env trimers as a platform for HIV-1 vaccine design

(2017) Rogier W. Sanders et al.   IMMUNOLOGICAL REVIEWS

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

(2017) Max Medina-Ramírez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dense Array of Spikes on HIV-1 Virion Particles

(2017) Armando Stano et al.   JOURNAL OF VIROLOGY

Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses

(2017) Shridhar Bale et al.   JOURNAL OF VIROLOGY

Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction

(2017) Ema T. Crooks et al.   VIROLOGY

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

(2017) Tongqing Zhou et al.   Cell Reports

Liposomal Formulations in Clinical Use: An Updated Review

(2017) Upendra Bulbake et al.   Pharmaceutics

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

(2016) Amelia Escolano et al.   CELL

HIV-1 envelope glycoprotein immunogens to induce broadly neutralizing antibodies

(2016) Kwinten Sliepen et al.   Expert Review of Vaccines

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

(2016) Jon M. Steichen et al.   IMMUNITY

Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer

(2016) J. H. Lee et al.   SCIENCE

Accurate design of megadalton-scale two-component icosahedral protein complexes

(2016) J. B. Bale et al.   SCIENCE

HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies

(2016) Steven W. de Taeye et al.   TRENDS IN IMMUNOLOGY

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

(2016) Linling He et al.   Nature Communications

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

(2016) Andrew T. McGuire et al.   Nature Communications

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells

(2016) Jidnyasa Ingale et al.   Cell Reports

Holes in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies

(2016) Laura E. McCoy et al.   Cell Reports

Self-assembling protein nanoparticles in the design of vaccines

(2016) Jacinto López-Sagaseta et al.   Computational and Structural Biotechnology Journal

Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization

(2016) Karl D. Brune et al.   Scientific Reports

Rational Design of an Epstein-Barr Virus Vaccine Targeting the Receptor-Binding Site

(2015) Masaru Kanekiyo et al.   CELL

Immunosilencing a Highly Immunogenic Protein Trimerization Domain

(2015) Kwinten Sliepen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity

(2015) Joyce K. Hu et al.   JOURNAL OF VIROLOGY

Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity

(2015) Kwinten Sliepen et al.   Retrovirology

Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen

(2015) J. G. Jardine et al.   SCIENCE

HIV-1 neutralizing antibodies induced by native-like envelope trimers

(2015) R. W. Sanders et al.   SCIENCE

Liposomal vaccines incorporating molecular adjuvants and intrastructural T-cell help promote the immunogenicity of HIV membrane-proximal external region peptides

(2015) Melissa C. Hanson et al.   VACCINE

Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers

(2015) Kwinten Sliepen et al.   VIROLOGY

Approaching rational epitope vaccine design for hepatitis C virus with meta-server and multivalent scaffolding

(2015) Linling He et al.   Scientific Reports

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

(2015) Ema T. Crooks et al.   PLoS Pathogens

Design of Lipid Nanocapsule Delivery Vehicles for Multivalent Display of Recombinant Env Trimers in HIV Vaccination

(2014) Sharmila Pejawar-Gaddy et al.   BIOCONJUGATE CHEMISTRY

Ending the Global HIV/AIDS Pandemic: The Critical Role of an HIV Vaccine

(2014) A. S. Fauci et al.   CLINICAL INFECTIOUS DISEASES

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41–gp120 interface

(2014) Jinghe Huang et al.   NATURE

A stamp on the envelope

(2014) Rogier W. Sanders et al.   NATURE

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

(2014) J. B. Munro et al.   SCIENCE

In vivo protection by broadly neutralizing HIV antibodies

(2014) Marit J. van Gils et al.   TRENDS IN MICROBIOLOGY

Why HIV Virions Have Low Numbers of Envelope Spikes: Implications for Vaccine Development

(2014) John Schiller et al.   PLoS Pathogens

Practical approaches to designing novel protein assemblies

(2013) Neil P King et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies

(2013) Masaru Kanekiyo et al.   NATURE

Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

(2013) J. Jardine et al.   SCIENCE

Virus-like particle-based human vaccines: quality assessment based on structural and functional properties

(2013) Qinjian Zhao et al.   TRENDS IN BIOTECHNOLOGY

HIV-1 Diversity in the Envelope Glycoproteins: Implications for Viral Entry Inhibition

(2013) Leonardo Araújo et al.   Viruses-Basel

Correction: Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs

(2013) Sam Hoot et al.   PLoS Pathogens

A Next-Generation Cleaved, Soluble HIV-1 Env Trimer, BG505 SOSIP.664 gp140, Expresses Multiple Epitopes for Broadly Neutralizing but Not Non-Neutralizing Antibodies

(2013) Rogier W. Sanders et al.   PLoS Pathogens

Biodegradable Particles as Vaccine Delivery Systems: Size Matters

(2012) Vijaya B. Joshi et al.   AAPS Journal

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

HIV Entry and Envelope Glycoprotein-mediated Fusion

(2012) Robert Blumenthal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study

(2012) Barton F Haynes et al.   NATURE BIOTECHNOLOGY

Enhancing humoral responses to a malaria antigen with nanoparticle vaccines that expand Tfh cells and promote germinal center induction

(2012) J. J. Moon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy

(2012) N. P. King et al.   SCIENCE

HIV-1 Envelope Glycoprotein Biosynthesis, Trafficking, and Incorporation

(2011) Mary Ann Checkley et al.   JOURNAL OF MOLECULAR BIOLOGY

Enzyme Digests Eliminate Nonfunctional Env from HIV-1 Particle Surfaces, Leaving Native Env Trimers Intact and Viral Infectivity Unaffected

(2011) E. T. Crooks et al.   JOURNAL OF VIROLOGY

Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses

(2011) James J. Moon et al.   NATURE MATERIALS

Neutralizing antibodies induced by liposomal HIV-1 glycoprotein 41 peptide simultaneously bind to both the 2F5 or 4E10 epitope and lipid epitopes

(2009) Gary R Matyas et al.   AIDS

Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens

(2009) Xiaodong Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Conduits Mediate Transport of Low-Molecular-Weight Antigen to Lymph Node Follicles

(2009) Ramon Roozendaal et al.   IMMUNITY

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Preclinical Studies To Understand Nanoparticle Interaction with the Immune System and Its Potential Effects on Nanoparticle Biodistribution

(2008) Marina A. Dobrovolskaia et al.   MOLECULAR PHARMACEUTICS

Molecular architecture of native HIV-1 gp120 trimers

(2008) Jun Liu et al.   NATURE