Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus
Authors
Keywords
-
Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-12-09
DOI
10.1038/s41467-021-27198-4
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption
- (2021) Irma Karabegović et al. Nature Communications
- Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
- (2021) Josine L. Min et al. NATURE GENETICS
- The mutational constraint spectrum quantified from variation in 141,456 humans
- (2020) Konrad J. Karczewski et al. NATURE
- The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion
- (2020) Kazi Mirajul Hoque et al. Nature Communications
- H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification
- (2019) Dario Nicetto et al. SCIENCE
- Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease
- (2019) Caroline Gluck et al. Nature Communications
- Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study
- (2019) Alexia Cardona et al. DIABETES
- Gout
- (2019) Nicola Dalbeth et al. Nature Reviews Disease Primers
- Molecular characterization of the orphan transporter SLC16A9, an extracellular pH- and Na+-sensitive creatine transporter
- (2019) Yuya Futagi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels
- (2019) Adrienne Tin et al. NATURE GENETICS
- Genome-wide identification of DNA methylation QTLs in whole blood highlights pathways for cardiovascular disease
- (2019) Tianxiao Huan et al. Nature Communications
- Urate‐induced immune programming: Consequences for gouty arthritis and hyperuricemia
- (2019) Georgiana Cabău et al. IMMUNOLOGICAL REVIEWS
- MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank
- (2018) Xue Li et al. ANNALS OF THE RHEUMATIC DISEASES
- An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells
- (2018) Elizabeth M. Kennedy et al. BMC GENOMICS
- The systems biology of uric acid transporters
- (2018) Sanjay K. Nigam et al. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
- Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases
- (2018) Masahiro Kanai et al. NATURE GENETICS
- An update on the genetics of hyperuricaemia and gout
- (2018) Tanya J. Major et al. Nature Reviews Rheumatology
- Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species
- (2018) Dafni Anastasiadi et al. Epigenetics & Chromatin
- The MR-Base platform supports systematic causal inference across the human phenome
- (2018) Gibran Hemani et al. eLife
- Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins
- (2018) Eilis Hannon et al. PLoS Genetics
- methylGSA: a Bioconductor package and Shiny app for DNA methylation data length bias adjustment in gene set testing
- (2018) Xu Ren et al. BIOINFORMATICS
- The Gene Ontology Resource: 20 years and still GOing strong
- (2018) NUCLEIC ACIDS RESEARCH
- Epigenome-Wide Association Study Identifies Methylation Sites Associated With Liver Enzymes and Hepatic Steatosis
- (2017) Jana Nano et al. GASTROENTEROLOGY
- Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption
- (2017) Fernando Pires Hartwig et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Identification of H3K4me1-associated proteins at mammalian enhancers
- (2017) Andrea Local et al. NATURE GENETICS
- The Reactome Pathway Knowledgebase
- (2017) Antonio Fabregat et al. NUCLEIC ACIDS RESEARCH
- Extending the MR-Egger method for multivariable Mendelian randomization to correct for both measured and unmeasured pleiotropy
- (2017) Jessica M. B. Rees et al. STATISTICS IN MEDICINE
- Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies
- (2017) Xue Li et al. BMJ-British Medical Journal
- Orienting the causal relationship between imprecisely measured traits using GWAS summary data
- (2017) Gibran Hemani et al. PLoS Genetics
- Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies
- (2017) Xue Li et al. BMJ-British Medical Journal
- Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
- (2016) Jack Bowden et al. GENETIC EPIDEMIOLOGY
- Regulation of uric acid metabolism and excretion
- (2016) Jessica Maiuolo et al. INTERNATIONAL JOURNAL OF CARDIOLOGY
- Epigenome-wide association study of body mass index and the adverse outcomes of adiposity
- (2016) Simone Wahl et al. NATURE
- Genetic and environmental influences interact with age and sex in shaping the human methylome
- (2016) Jenny van Dongen et al. Nature Communications
- eFORGE: A Tool for Identifying Cell Type-Specific Signal in Epigenomic Data
- (2016) Charles E. Breeze et al. Cell Reports
- Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes
- (2015) Hirotaka Matsuo et al. ANNALS OF THE RHEUMATIC DISEASES
- Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra
- (2015) Tania O Crișan et al. ANNALS OF THE RHEUMATIC DISEASES
- The Molecular Physiology of Uric Acid Homeostasis
- (2015) Asim K. Mandal et al. Annual Review of Physiology
- Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
- (2015) J. Bowden et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- Integrative analysis of 111 reference human epigenomes
- (2015) Anshul Kundaje et al. NATURE
- Tissue-based map of the human proteome
- (2015) M. Uhlen et al. SCIENCE
- Conducting Meta-Analyses inRwith themetaforPackage
- (2015) Wolfgang Viechtbauer Journal of Statistical Software
- ABCG2 Dysfunction Increases Serum Uric Acid by Decreased Intestinal Urate Excretion
- (2014) Tappei Takada et al. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
- Expression of SLC2A9 Isoforms in the Kidney and Their Localization in Polarized Epithelial Cells
- (2014) Toru Kimura et al. PLoS One
- Epidemiology of Gout
- (2014) Edward Roddy et al. RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
- Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9
- (2014) Brian J DeBosch et al. Nature Communications
- Contribution of genetic variation to transgenerational inheritance of DNA methylation
- (2014) Allan F McRae et al. GENOME BIOLOGY
- Uric acid transporter ABCG2 is increased in the intestine of the 5/6 nephrectomy rat model of chronic kidney disease
- (2013) Hirofumi Yano et al. Clinical and Experimental Nephrology
- Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data
- (2013) Stephen Burgess et al. GENETIC EPIDEMIOLOGY
- Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits
- (2013) Ann-Kristin Petersen et al. HUMAN MOLECULAR GENETICS
- The SLC1 high-affinity glutamate and neutral amino acid transporter family
- (2013) Yoshikatsu Kanai et al. MOLECULAR ASPECTS OF MEDICINE
- The SLC3 and SLC7 families of amino acid transporters
- (2013) Dimitrios Fotiadis et al. MOLECULAR ASPECTS OF MEDICINE
- DNA methylation arrays as surrogate measures of cell mixture distribution
- (2012) Eugene Houseman et al. BMC BIOINFORMATICS
- Genetic and epigenetic contribution to complex traits
- (2012) H. Kilpinen et al. HUMAN MOLECULAR GENETICS
- The small SLC43 family: Facilitator system l amino acid transporters and the orphan EEG1
- (2012) Susanna Bodoy et al. MOLECULAR ASPECTS OF MEDICINE
- Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
- (2012) Anna Köttgen et al. NATURE GENETICS
- Body mass index, obesity, and prevalent gout in the United States in 1988-1994 and 2007-2010
- (2012) Stephen P. Juraschek et al. ARTHRITIS CARE & RESEARCH
- Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele
- (2011) Adrienne Tin et al. HUMAN MOLECULAR GENETICS
- Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
- (2011) Jaspal S Kooner et al. NATURE GENETICS
- ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity
- (2011) Matthew D. Young et al. NUCLEIC ACIDS RESEARCH
- GCTA: A Tool for Genome-wide Complex Trait Analysis
- (2010) Jian Yang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors
- (2010) Qiong Yang et al. Circulation-Cardiovascular Genetics
- Biological, clinical and population relevance of 95 loci for blood lipids
- (2010) Tanya M. Teslovich et al. NATURE
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
- (2010) Benjamin F Voight et al. NATURE GENETICS
- Identification, Inference and Sensitivity Analysis for Causal Mediation Effects
- (2010) Kosuke Imai et al. STATISTICAL SCIENCE
- Association Between Serum Uric Acid and Development of Type 2 Diabetes
- (2009) S. Kodama et al. DIABETES CARE
- Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy
- (2009) F. Preitner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
- (2009) O. M. Woodward et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Plasma Urate Level Is Directly Regulated by a Voltage-driven Urate Efflux Transporter URATv1 (SLC2A9) in Humans
- (2008) Naohiko Anzai et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout
- (2008) Veronique Vitart et al. NATURE GENETICS
- SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
- (2008) Angela Döring et al. NATURE GENETICS
- DNA methylation landscapes: provocative insights from epigenomics
- (2008) Miho M. Suzuki et al. NATURE REVIEWS GENETICS
- Uric Acid and Cardiovascular Risk
- (2008) Daniel I. Feig et al. NEW ENGLAND JOURNAL OF MEDICINE
- Mutations in the SLC2A9 Gene Cause Hyperuricosuria and Hyperuricemia in the Dog
- (2008) Danika Bannasch et al. PLoS Genetics
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started