Orienting the causal relationship between imprecisely measured traits using GWAS summary data

Shared genetic control of expression and methylation in peripheral blood

(2016) Konstantin Shakhbazov et al.   BMC GENOMICS

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Challenges and novel approaches for investigating molecular mediation

(2016) R.C. Richmond et al.   HUMAN MOLECULAR GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children

(2015) Xiumei Hong et al.   Nature Communications

Evaluation of microarray-based DNA methylation measurement using technical replicates: the Atherosclerosis Risk In Communities (ARIC) Study

(2014) Maitreyee Bose et al.   BMC BIOINFORMATICS

Integrative genomic analysis identifies epigenetic marks that mediate genetic risk for epithelial ovarian cancer

(2014) Devin C Koestler et al.   BMC Medical Genomics

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways

(2014) S. Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions

(2014) Stephen Burgess et al.   PLoS One

Genotype-based treatment of type 2 diabetes with an  2A-adrenergic receptor antagonist

(2014) Y. Tang et al.   Science Translational Medicine

An integrated epigenomic analysis for type 2 diabetes susceptibility loci in monozygotic twins

(2014) Wei Yuan et al.   Nature Communications

Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis

(2014) Rebecca C. Richmond et al.   PLOS MEDICINE

Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators

(2013) B. L. Pierce et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Batch Effects and Pathway Analysis: Two Potential Perils in Cancer Studies Involving DNA Methylation Array Analysis

(2013) K. N. Harper et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

(2013) Yi-an Chen et al.   Epigenetics

Misclassification of the mediator matters when estimating indirect effects

(2013) Tony Blakely et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

(2013) Yun Liu et al.   NATURE BIOTECHNOLOGY

Common variants associated with plasma triglycerides and risk for coronary artery disease

(2013) Ron Do et al.   NATURE GENETICS

Novel Genetic Analysis for Case-Control Genome-Wide Association Studies: Quantification of Power and Genomic Prediction Accuracy

(2013) Sang Hong Lee et al.   PLoS One

Impact of Noise on Molecular Network Inference

(2013) Radhakrishnan Nagarajan et al.   PLoS One

The Health Risk of Obesity--Better Metrics Imperative

(2013) R. S. Ahima et al.   SCIENCE

DNA methylation arrays as surrogate measures of cell mixture distribution

(2012) Eugene Houseman et al.   BMC BIOINFORMATICS

Quantification of Bias in Direct Effects Estimates Due to Different Types of Measurement Error in the Mediator

(2012) Saskia le Cessie et al.   EPIDEMIOLOGY

The effect of non-differential measurement error on bias, precision and power in Mendelian randomization studies

(2012) Brandon L Pierce et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

(2012) Caroline L Relton et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Technical Variability Is Greater than Biological Variability in a Microarray Experiment but Both Are Outweighed by Changes Induced by Stimulation

(2011) Penelope A. Bryant et al.   PLoS One

Measurement and Meaning in Biology

(2011) David Houle et al.   QUARTERLY REVIEW OF BIOLOGY

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

(2010) N J Timpson et al.   INTERNATIONAL JOURNAL OF OBESITY

Invited Commentary: Causal Diagrams and Measurement Bias

(2009) M. A. Hernan et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Disentangling molecular relationships with a causal inference test

(2009) Joshua Millstein et al.   BMC GENETICS

Using genetic markers to orient the edges in quantitative trait networks: The NEO software

(2008) Jason E Aten et al.   BMC Systems Biology