An update on the genetics of hyperuricaemia and gout

Association between ABCG2 rs2231142 and poor response to allopurinol: replication and meta-analysis

(2018) Mary C Wallace et al.   RHEUMATOLOGY

ABCG2 Polymorphism Is Associated with Hyperuricemia in a Study of a Community-Based Korean Cohort

(2017) Chang-Nam Son et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

The age-structured incidence and mortality of pulmonary tuberculosis reported in China, in 2005–15: a longitudinal analysis of national surveillance data

(2017) Jun Li et al.   LANCET

Functional non-synonymous variants of ABCG2 and gout risk

(2017) Blanka Stiburkova et al.   RHEUMATOLOGY

Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants

(2017) Reka Nagy et al.   Genome Medicine

Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men

(2017) Callum Tanner et al.   Arthritis & Rheumatology

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

(2016) Akiyoshi Nakayama et al.   ANNALS OF THE RHEUMATIC DISEASES

2016 updated EULAR evidence-based recommendations for the management of gout

(2016) P Richette et al.   ANNALS OF THE RHEUMATIC DISEASES

Uric acid in metabolic syndrome: From an innocent bystander to a central player

(2016) Mehmet Kanbay et al.   European Journal of Internal Medicine

Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

(2016) Tanya Keenan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Gout

(2016) Nicola Dalbeth et al.   LANCET

Insight into rheumatological cause and effect through the use of Mendelian randomization

(2016) Philip C. Robinson et al.   Nature Reviews Rheumatology

ABCG2 loss-of-function polymorphism predicts poor response to allopurinol in patients with gout

(2016) R L Roberts et al.   PHARMACOGENOMICS JOURNAL

Replication of association of the apolipoprotein A1-C3-A4 gene cluster with the risk of gout

(2016) Humaira Rasheed et al.   RHEUMATOLOGY

Association analysis of five SNP variants with gout in the Minnan population in China

(2016) Chenna ZHENG et al.   Turkish Journal Of Medical Sciences

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis

(2016) Jon White et al.   Lancet Diabetes & Endocrinology

Urate crystal deposition in asymptomatic hyperuricaemia and symptomatic gout: a dual energy CT study

(2015) Nicola Dalbeth et al.   ANNALS OF THE RHEUMATIC DISEASES

Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes

(2015) Hirotaka Matsuo et al.   ANNALS OF THE RHEUMATIC DISEASES

Soluble uric acid primes TLR-induced proinflammatory cytokine production by human primary cells via inhibition of IL-1Ra

(2015) Tania O Crișan et al.   ANNALS OF THE RHEUMATIC DISEASES

Factors influencing the crystallization of monosodium urate: a systematic literature review

(2015) Ashika Chhana et al.   BMC MUSCULOSKELETAL DISORDERS

CARD8 rs2043211 Polymorphism is Associated with Gout in a Chinese Male Population

(2015) Ying Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Genome-wide association study identifies ABCG2 (BCRP) as an allopurinol transporter and a determinant of drug response

(2015) CC Wen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes

(2015) Ivonne Sluijs et al.   DIABETES

Genomics and metabolomics of muscular mass in a community-based sample of UK females

(2015) Michael Korostishevsky et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Polymorphisms of uric transporter proteins in the pathogenesis of gout in a Chinese Han population

(2015) W. Wan et al.   GENETICS AND MOLECULAR RESEARCH

Genomic prediction of complex human traits: relatedness, trait architecture and predictive meta-models

(2015) A. Spiliopoulou et al.   HUMAN MOLECULAR GENETICS

Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans

(2015) Jennifer E. Huffman et al.   PLoS One

Serum urate gene associations with incident gout, measured in the Framingham Heart Study, are modified by renal disease and not by body mass index

(2015) Richard J. Reynolds et al.   RHEUMATOLOGY INTERNATIONAL

Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout

(2015) Cushla McKinney et al.   ARTHRITIS RESEARCH & THERAPY

An update on the genetic architecture of hyperuricemia and gout

(2015) Tony R Merriman   ARTHRITIS RESEARCH & THERAPY

Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese

(2015) Changgui Li et al.   Nature Communications

Genetic analysis of <i>ABCG2</i> and <i>SLC2A9</i> gene polymorphisms in gouty arthritis in a Korean population

(2015) Yun Sung Kim et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Twenty-eight loci that influence serum urate levels: analysis of association with gout

(2014) A J Phipps-Green et al.   ANNALS OF THE RHEUMATIC DISEASES

Copy number polymorphisms near SLC2A9 are associated with serum uric acid concentrations

(2014) Robert B Scharpf et al.   BMC GENETICS

Mendelian Randomization Provides No Evidence for a Causal Role of Serum Urate in Increasing Serum Triglyceride Levels

(2014) H. Rasheed et al.   Circulation-Cardiovascular Genetics

Gout: Joints and beyond, epidemiology, clinical features, treatment and co-morbidities

(2014) Philip C. Robinson et al.   MATURITAS

The Genetic Basis of Gout

(2014) Tony R. Merriman et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Increased level of MSU crystal-bound protein apolipoprotein A-I in acute gouty arthritis

(2014) S-L Chiang et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Impaired response or insufficient dosage?—Examining the potential causes of “inadequate response” to allopurinol in the treatment of gout

(2014) Lisa K. Stamp et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Revisiting comorbidities in gout: a cluster analysis

(2013) Pascal Richette et al.   ANNALS OF THE RHEUMATIC DISEASES

Tendon involvement in the feet of patients with gout: a dual-energy CT study

(2013) Nicola Dalbeth et al.   ANNALS OF THE RHEUMATIC DISEASES

Sugar-sweetened beverage consumption: a risk factor for prevalent gout withSLC2A9genotype-specific effects on serum urate and risk of gout

(2013) Caitlin Batt et al.   ANNALS OF THE RHEUMATIC DISEASES

ALDH16A1 is a novel non-catalytic enzyme that may be involved in the etiology of gout via protein–protein interactions with HPRT1

(2013) Vasilis Vasiliou et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Trans-ethnic fine mapping identifies a novel independent locus at the 3′ end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population

(2013) Jane Z. Kuo et al.   DIABETOLOGIA

Effect of Genetic Polymorphisms on Development of Gout

(2013) W. Urano et al.   JOURNAL OF RHEUMATOLOGY

Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function

(2013) Kim Hughes et al.   KIDNEY INTERNATIONAL

Association of the lipoprotein receptor-related protein 2 gene with gout and non-additive interaction with alcohol consumption

(2013) Humaira Rasheed et al.   ARTHRITIS RESEARCH & THERAPY

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

(2013) T. M. Palmer et al.   BMJ-British Medical Journal

Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans

(2013) Venkata Saroja Voruganti et al.   Frontiers in Genetics

Nature Versus Nurture in Gout: A Twin Study

(2012) Eswar Krishnan et al.   AMERICAN JOURNAL OF MEDICINE

Genome-Wide Association of Serum Uric Acid Concentration: Replication of Sequence Variants in an Island Population of the Adriatic Coast of Croatia

(2012) Rebekah Karns et al.   ANNALS OF HUMAN GENETICS

Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter

(2012) A. Basseville et al.   CANCER RESEARCH

Association between gout and polymorphisms in GCKR in male Han Chinese

(2012) Jing Wang et al.   HUMAN GENETICS

Genetic architecture for susceptibility to gout in the KARE cohort study

(2012) Jimin Shin et al.   JOURNAL OF HUMAN GENETICS

Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations

(2012) Yukinori Okada et al.   NATURE GENETICS

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Serum Uric Acid and Adiposity: Deciphering Causality Using a Bidirectional Mendelian Randomization Approach

(2012) Tanica Lyngdoh et al.   PLoS One

2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia

(2012) Dinesh Khanna et al.   ARTHRITIS CARE & RESEARCH

The renal urate transporter SLC17A1 locus: confirmation of association with gout

(2012) Jade E Hollis-Moffatt et al.   ARTHRITIS RESEARCH & THERAPY

Decreased extra-renal urate excretion is a common cause of hyperuricemia

(2012) Kimiyoshi Ichida et al.   Nature Communications

Prevalence of gout and hyperuricemia in the US general population: The National Health and Nutrition Examination Survey 2007-2008

(2011) Yanyan Zhu et al.   ARTHRITIS AND RHEUMATISM

Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits

(2011) Rita PS Middelberg et al.   BMC Medical Genetics

A genome-wide association study of serum uric acid in African Americans

(2011) Bashira A Charles et al.   BMC Medical Genomics

Cellular characterisation of the GCKR P446L variant associated with type 2 diabetes risk

(2011) M. G. Rees et al.   DIABETOLOGIA

Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele

(2011) Adrienne Tin et al.   HUMAN MOLECULAR GENETICS

Interleukin 1B Variant -1473G/C (rs1143623) Influences Triglyceride and Interleukin 6 Metabolism

(2011) Javier Delgado-Lista et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Human metabolic individuality in biomedical and pharmaceutical research

(2011) Karsten Suhre et al.   NATURE

Identification of low-frequency variants associated with gout and serum uric acid levels

(2011) Patrick Sulem et al.   NATURE GENETICS

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

GCTA: A Tool for Genome-wide Complex Trait Analysis

(2010) Jian Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cellular characterization of the gouty tophus: A quantitative analysis

(2010) Nicola Dalbeth et al.   ARTHRITIS AND RHEUMATISM

Multiple Genetic Loci Influence Serum Urate Levels and Their Relationship With Gout and Cardiovascular Disease Risk Factors

(2010) Qiong Yang et al.   Circulation-Cardiovascular Genetics

Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population

(2010) E. E. Kenny et al.   HUMAN MOLECULAR GENETICS

Genome-wide association study of hematological and biochemical traits in a Japanese population

(2010) Yoichiro Kamatani et al.   NATURE GENETICS

A specific interleukin-1B haplotype correlates with high levels of IL1B mRNA in the lung and increased risk of non-small cell lung cancer

(2009) Nina E. Landvik et al.   CARCINOGENESIS

Genome-wide Association Study of Biochemical Traits in Korčula Island, Croatia

(2009) Tatijana Zemunik et al.   CROATIAN MEDICAL JOURNAL

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

(2009) Nicola L. Beer et al.   HUMAN MOLECULAR GENETICS

Common Polymorphisms Influencing Serum Uric Acid Levels Contribute to Susceptibility to Gout, but Not to Coronary Artery Disease

(2009) Klaus Stark et al.   PLoS One

Heritabilities for fifteen routine biochemical values: findings in 215 Swedish twin pairs 82 years of age or older

(2009) Sven E. Nilsson et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population

(2009) H. Matsuo et al.   Science Translational Medicine

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia

(2008) Chris Wallace et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish

(2008) Patrick F. McArdle et al.   ARTHRITIS AND RHEUMATISM

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

(2008) Abbas Dehghan et al.   LANCET

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout

(2008) Veronique Vitart et al.   NATURE GENETICS

SLC2A9 influences uric acid concentrations with pronounced sex-specific effects

(2008) Angela Döring et al.   NATURE GENETICS