Betulin suppresses TNF-α and IL-1β production in osteoarthritis synovial fibroblasts by inhibiting the MEK/ERK/NF-κB pathway

Prostaglandin E2 induces dual-specificity phosphatase-1, thereby attenuating inflammatory genes expression in human osteoarthritic synovial fibroblasts

(2021) Asato Maekawa et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Soya-cerebroside inhibits VEGF-facilitated angiogenesis in endothelial progenitor cells

(2020) Hsiang-Ping Lee et al.   FOOD AND AGRICULTURAL IMMUNOLOGY

The Role of Inflammation in the Pathogenesis of Osteoarthritis

(2020) Yoke Yue Chow et al.   MEDIATORS OF INFLAMMATION

Apelin enhances IL-1β expression in human synovial fibroblasts by inhibiting miR-144-3p through the PI3K and ERK pathways

(2020) Ting-Kuo Chang et al.   Aging-US

Visfatin Increases VEGF-Dependent Angiogenesis of Endothelial Progenitor Cells during Osteoarthritis Progression

(2020) Chun-Hao Tsai et al.   Cells

Urban Particulate Matter Enhances ROS/IL-6/COX-II Production by Inhibiting MicroRNA-137 in Synovial Fibroblast of Rheumatoid Arthritis

(2020) Ming-Horng Tsai et al.   Cells

Resistin enhances IL-1β and TNF-α expression in human osteoarthritis synovial fibroblasts by inhibiting miR-149 expression via the MEK and ERK pathways

(2020) Wei-Cheng Chen et al.   FASEB JOURNAL

PM2.5 facilitates IL‐6 production in human osteoarthritis synovial fibroblasts via ASK1 activation

(2020) Ju‐Fang Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: implications for the treatment of rheumatoid arthritis

(2019) Chien-Chung Huang et al.   JOURNAL OF PINEAL RESEARCH

TNF-α mediated MEK-ERK signaling in invasion with putative network involving NF-κB and STAT-6: a new perspective in glioma

(2019) Palaniswamy Ramaswamy et al.   CELL BIOLOGY INTERNATIONAL

Research of Pathogenesis and Novel Therapeutics in Arthritis

(2019) Chih-Hsin Tang   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TGF-β1 enhances FOXO3 expression in human synovial fibroblasts by inhibiting miR-92a through AMPK and p38 pathways

(2019) Shu-Jui Kuo et al.   Aging-US

Emerging Trend in the Pharmacotherapy of Osteoarthritis

(2019) Wei Zhang et al.   Frontiers in Endocrinology

Thrombospondin enhances RANKL-dependent osteoclastogenesis and facilitates lung cancer bone metastasis

(2019) Maofeng Wang et al.   BIOCHEMICAL PHARMACOLOGY

The IL-1 family of cytokines and receptors in rheumatic diseases

(2019) Charles Anthony Dinarello   Nature Reviews Rheumatology

Combinational treatment of all‐trans retinoic acid (ATRA) and bisdemethoxycurcumin (BDMC)‐induced apoptosis in liver cancer Hep3B cells

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Advanced oxidation protein products increase TNF-α and IL-1β expression in chondrocytes via NADPH oxidase 4 and accelerate cartilage degeneration in osteoarthritis progression

(2019) Cong-Rui Liao et al.   Redox Biology

Glucose suppresses IL-1β-induced MMP-1 expression through the FAK, MEK, ERK, and AP-1 signaling pathways

(2018) Tsung-Ju Wu et al.   ENVIRONMENTAL TOXICOLOGY

Redox and NF-κB signaling in osteoarthritis

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Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, β-catenin, and Twist pathways

(2018) Yi-Chen Yang et al.   ENVIRONMENTAL TOXICOLOGY

Plumbagin suppresses endothelial progenitor cell-related angiogenesis in vitro and in vivo

(2018) Hsiang-Ping Lee et al.   Journal of Functional Foods

Betulin suppressed interleukin-1β-induced gene expression, secretion and proteolytic activity of matrix metalloproteinase in cultured articular chondrocytes and production of matrix metalloproteinase in the knee joint of rat

(2017) Ho Jong Ra et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Electroacupuncture serum inhibits TNF-α-mediated chondrocyte inflammation via the Ras-Raf-MEK1/2-ERK1/2 signaling pathway

(2017) Houhuang Chen et al.   Molecular Medicine Reports

Transforming growth factor β1 enhances heme oxygenase 1 expression in human synovial fibroblasts by inhibiting microRNA 519b synthesis

(2017) Shu-Jui Kuo et al.   PLoS One

Rheumatoid arthritis

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Mechanisms leading from systemic autoimmunity to joint-specific disease in rheumatoid arthritis

(2016) Anca I. Catrina et al.   Nature Reviews Rheumatology

Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway

(2016) Ting Bai et al.   PHARMACOLOGICAL RESEARCH

Betulinic acid inhibits IL-1β-induced inflammation by activating PPAR-γ in human osteoarthritis chondrocytes

(2015) Wang Jingbo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Osteopontin Promotes Oncostatin M Production in Human Osteoblasts: Implication of Rheumatoid Arthritis Therapy

(2015) Chen-Ming Su et al.   JOURNAL OF IMMUNOLOGY

Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings

(2015) Thomas Pap et al.   Nature Reviews Rheumatology

Role of Synovial Fibroblasts in Rheumatoid Arthritis

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Betulinic acid isolated from Vitis amurensis root inhibits 3-isobutyl-1-methylxanthine induced melanogenesis via the regulation of MEK/ERK and PI3K/Akt pathways in B16F10 cells

(2014) Kyong-Suk Jin et al.   FOOD AND CHEMICAL TOXICOLOGY

5-Lipoxygenase Inhibitors Attenuate TNF-α-Induced Inflammation in Human Synovial Fibroblasts

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Biologic agents in osteoarthritis: hopes and disappointments

(2013) Xavier Chevalier et al.   Nature Reviews Rheumatology

CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

(2013) Chun-Han Hou et al.   ARTHRITIS RESEARCH & THERAPY

CTGF induces monocyte chemoattractant protein-1 expression to enhance monocyte migration in human synovial fibroblasts

(2012) Shan-Chi Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Pathogenesis of Rheumatoid Arthritis

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Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts

(2009) Sebastian Jäger et al.   MOLECULES