Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate

Single-Molecule Analysis of Lipid–Protein Interactions in Crude Cell Lysates

(2016) Edwin Arauz et al.   ANALYTICAL CHEMISTRY

Covalent Ras Dimerization on Membrane Surfaces through Photosensitized Oxidation

(2016) Jean K. Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Monitoring the Waiting Time Sequence of Single Ras GTPase Activation Events Using Liposome Functionalized Zero-Mode Waveguides

(2016) Sune M. Christensen et al.   NANO LETTERS

One-way membrane trafficking of SOS in receptor-triggered Ras activation

(2016) Sune M Christensen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

One-way membrane trafficking of SOS in receptor-triggered Ras activation

(2016) Sune M Christensen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single Cell GFP-Trap Reveals Stoichiometry and Dynamics of Cytosolic Protein Complexes

(2015) Tim Wedeking et al.   NANO LETTERS

Conformational dynamics of a class C G-protein-coupled receptor

(2015) Reza Vafabakhsh et al.   NATURE

Dark-Field-Based Observation of Single-Nanoparticle Dynamics on a Supported Lipid Bilayer for In Situ Analysis of Interacting Molecules and Nanoparticles

(2014) Young Kwang Lee et al.   CHEMPHYSCHEM

Massively Parallel and Highly Quantitative Single-Particle Analysis on Interactions between Nanoparticles on Supported Lipid Bilayer

(2014) Young Kwang Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tracking single molecules at work in living cells

(2014) Akihiro Kusumi et al.   Nature Chemical Biology

H-Ras forms dimers on membrane surfaces via a protein-protein interface

(2014) W.-C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics

(2014) L. Iversen et al.   SCIENCE

Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor

(2013) Caleb B. McDonald et al.   BIOPHYSICAL CHEMISTRY

Interaction Domains of Sos1/Grb2 Are Finely Tuned for Cooperative Control of Embryonic Stem Cell Fate

(2013) Greg M. Findlay et al.   CELL

Activation of Extracellular Signal-Regulated Kinase but Not of p38 Mitogen-Activated Protein Kinase Pathways in Lymphocytes Requires Allosteric Activation of SOS

(2013) J. E. Jun et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics

(2013) Hong-Won Lee et al.   Nature Communications

Single-molecule pull-down for studying protein interactions

(2012) Ankur Jain et al.   Nature Protocols

Electrofluidic Lipid Membrane Biosensor

(2012) Young Kwang Lee et al.   Small

Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis

(2012) Hao-Hsuan Jeng et al.   Nature Communications

SOS1 mutations in Noonan syndrome: molecular spectrum, structural insights on pathogenic effects, and genotype-phenotype correlations

(2011) Francesca Lepri et al.   HUMAN MUTATION

Using patterned supported lipid membranes to investigate the role of receptor organization in intercellular signaling

(2011) Pradeep M Nair et al.   Nature Protocols

Targeted Sos1 deletion reveals its critical role in early T-cell development

(2011) R. L. Kortum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single Molecule Diffusion of Membrane-Bound Proteins: Window into Lipid Contacts and Bilayer Dynamics

(2010) Jefferson D. Knight et al.   BIOPHYSICAL JOURNAL

Single-molecule imaging reveals mechanisms of protein disruption by a DNA translocase

(2010) Ilya J. Finkelstein et al.   NATURE

Molecular mechanisms in signal transduction at the membrane

(2010) Jay T Groves et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of the histone domain in the autoinhibition and activation of the Ras activator Son of Sevenless

(2010) Jodi Gureasko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric gating of Son of sevenless activity by the histone domain

(2010) Kamlesh K. Yadav et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

How is SOS activated? Let us count the ways

(2008) Greg M Findlay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Membrane-dependent signal integration by the Ras activator Son of sevenless

(2008) Jodi Gureasko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY