Sepsis: a failing starvation response

Inhibition of aerobic glycolysis alleviates sepsis‑induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK‑regulated autophagy

(2021) Chuyi Tan et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

(2021) Rabina Mainali et al.   eLife

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis

(2021) Kun Yang et al.   CELL DEATH AND DIFFERENTIATION

Combined glucocorticoid resistance and hyperlactatemia contributes to lethal shock in sepsis

(2021) Jolien Vandewalle et al.   Cell Metabolism

PPAR control of metabolism and cardiovascular functions

(2021) David Montaigne et al.   Nature Reviews Cardiology

The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages

(2021) Sri Murugan Poongkavithai Vadevoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aerobic exercise improves LPS-induced sepsis via regulating the Warburg effect in mice

(2021) Xishuai Wang et al.   Scientific Reports

Evaluation of the Molecular Mechanisms of Sepsis Using Proteomics

(2021) He Miao et al.   Frontiers in Immunology

Epigenetics of Sepsis

(2020) Alexandra Binnie et al.   CRITICAL CARE MEDICINE

Hepatic PPARα function and lipid metabolic pathways are dysregulated in polymicrobial sepsis

(2020) Lise Van Wyngene et al.   EMBO Molecular Medicine

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

Prediction of sepsis mortality using metabolite biomarkers in the blood: a meta-analysis of death-related pathways and prospective validation

(2020) Jing Wang et al.   BMC Medicine

Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells

(2020) Qi Yan Ang et al.   CELL

SARS-CoV-2 and viral sepsis: observations and hypotheses

(2020) Hui Li et al.   LANCET

Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling

(2020) Eman Khatib-Massalha et al.   Nature Communications

Glucocorticoids in Sepsis: To Be or Not to Be

(2020) Jolien Vandewalle et al.   Frontiers in Immunology

Programing of an Intravascular Immune Firewall by the Gut Microbiota Protects against Pathogen Dissemination during Infection

(2020) Braedon McDonald et al.   Cell Host & Microbe

Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling

(2020) Kun Yang et al.   Frontiers in Immunology

Kupffer Cells Sense Free Fatty Acids and Regulate Hepatic Lipid Metabolism in High-Fat Diet and Inflammation

(2020) Kira L. Diehl et al.   Cells

The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

(2020) Ahmad A. Cluntun et al.   Cell Metabolism

Hepatic PPARα is critical in the metabolic adaptation to sepsis

(2019) Réjane Paumelle et al.   JOURNAL OF HEPATOLOGY

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

(2019) Weina Zhang et al.   CELL

Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis

(2019) Deepak Kumar Kaushik et al.   JOURNAL OF CLINICAL INVESTIGATION

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

(2019) Karen Dendoncker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A General Introduction to Glucocorticoid Biology

(2019) Steven Timmermans et al.   Frontiers in Immunology

Metabolic regulation of gene expression by histone lactylation

(2019) Di Zhang et al.   NATURE

Glycolysis dependent lactate formation in neutrophils: A metabolic link between NOX-dependent and independent NETosis

(2019) Deepika Awasthi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

(2019) Valentina Pucino et al.   Cell Metabolism

Do critical care patients hibernate? Theoretical support for less is more

(2019) Giacomo Stanzani et al.   INTENSIVE CARE MEDICINE

Subcutaneous administration of β-hydroxybutyrate improves learning and memory of sepsis surviving mice

(2019) Xueqin Wang et al.   Neurotherapeutics

Glycerol not lactate is the major net carbon source for gluconeogenesis in mice during both short and prolonged fasting

(2019) Yujue Wang et al.   Molecular Metabolism

Nutrition Therapy in Sepsis

(2018) Paul E. Wischmeyer   CRITICAL CARE CLINICS

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?

(2018) Lise Van Wyngene et al.   EMBO Molecular Medicine

Mechanisms and treatment of organ failure in sepsis

(2018) Christophe Lelubre et al.   Nature Reviews Nephrology

Adjunctive Glucocorticoid Therapy in Patients with Septic Shock

(2018) Balasubramanian Venkatesh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

(2018) Djillali Annane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Mechanisms of Glucocorticoids

(2018) Jolien Vandewalle et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

Enhanced Glycolytic Metabolism Contributes to Cardiac Dysfunction in Polymicrobial Sepsis

(2017) Zhibo Zheng et al.   JOURNAL OF INFECTIOUS DISEASES

Recognizing Sepsis as a Global Health Priority — A WHO Resolution

(2017) Konrad Reinhart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation

(2016) Andrew Wang et al.   CELL

Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes

(2016) Pete J. Cox et al.   Cell Metabolism

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

(2016) Almut Brand et al.   Cell Metabolism

Lactic Acidosis in Sepsis: It’s Not All Anaerobic

(2016) Bandarn Suetrong et al.   CHEST

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

(2016) Min Xie et al.   Nature Communications

Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

(2016) Gianpaolo Rando et al.   eLife

Premorbid obesity, but not nutrition, prevents critical illness-induced muscle wasting and weakness

(2016) Chloë Goossens et al.   Journal of Cachexia Sarcopenia and Muscle

Sepsis and septic shock

(2016) Richard S. Hotchkiss et al.   Nature Reviews Disease Primers

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

Endothelial barrier dysfunction in septic shock

(2015) S. M. Opal et al.   JOURNAL OF INTERNAL MEDICINE

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle

(2015) Tomohiro Suhara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of G Protein-Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury

(2014) Zhe Shen et al.   CNS Neuroscience & Therapeutics

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

(2014) Rafaz Hoque et al.   GASTROENTEROLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

(2014) Liangchun Yang et al.   Nature Communications

An Integrated Clinico-Metabolomic Model Improves Prediction of Death in Sepsis

(2013) R. J. Langley et al.   Science Translational Medicine

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages

(2011) Anna Kleiman et al.   FASEB JOURNAL

Tumor Necrosis Factor Inhibits Glucocorticoid Receptor Function in Mice

(2011) Tom Van Bogaert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of c-Jun-N-terminal Kinase Increases Cardiac Peroxisome Proliferator-activated Receptor α Expression and Fatty Acid Oxidation and Prevents Lipopolysaccharide-induced Heart Dysfunction

(2011) Konstantinos Drosatos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kupffer cell depletion reduces hepatic inflammation and apoptosis but decreases survival in abdominal sepsis

(2010) Tobias Traeger et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Adequacy of Oral Intake in Critically Ill Patients 1 Week after Extubation

(2010) Sarah J. Peterson et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

Noncoding RNA Gas5 Is a Growth Arrest- and Starvation-Associated Repressor of the Glucocorticoid Receptor

(2010) T. Kino et al.   Science Signaling

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications

(2009) Nancy Nader et al.   FASEB JOURNAL

Kupffer cells promote hepatic steatosis via interleukin-1β-dependent suppression of peroxisome proliferator-activated receptor α activity

(2009) Rinke Stienstra et al.   HEPATOLOGY