Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 37, Pages 11642-11647
Publisher
Proceedings of the National Academy of Sciences
Online
2015-09-01
DOI
10.1073/pnas.1515872112
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Prolyl-hydroxylase PHD3 interacts with pyruvate dehydrogenase (PDH)-E1β and regulates the cellular PDH activity
- (2014) Daisuke Kikuchi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Metformin in Patients With Type 2 Diabetes and Kidney Disease
- (2014) Silvio E. Inzucchi et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The SLC16 gene family – Structure, role and regulation in health and disease
- (2013) Andrew P. Halestrap MOLECULAR ASPECTS OF MEDICINE
- Energy Management by Enhanced Glycolysis in G1-phase in Human Colon Cancer Cells In Vitro and In Vivo
- (2013) Y. Bao et al. MOLECULAR CANCER RESEARCH
- A liver Hif-2α–Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition
- (2013) Kevin Wei et al. NATURE MEDICINE
- Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes
- (2013) Cullen M Taniguchi et al. NATURE MEDICINE
- Severe Sepsis and Septic Shock
- (2013) Derek C. Angus et al. NEW ENGLAND JOURNAL OF MEDICINE
- Normal-Range Blood Lactate Concentration in Septic Shock Is Prognostic and Predictive
- (2012) Petch Wacharasint et al. SHOCK
- Hepatic expression and cellular distribution of the glucose transporter family
- (2012) Sumera Karim WORLD JOURNAL OF GASTROENTEROLOGY
- Oxygen Sensing, Homeostasis, and Disease
- (2011) Gregg L. Semenza NEW ENGLAND JOURNAL OF MEDICINE
- The Hydroxylase Inhibitor Dimethyloxallyl Glycine Attenuates Endotoxic Shock Via Alternative Activation of Macrophages and IL-10 Production by B1 Cells
- (2011) Emily Hams et al. SHOCK
- Early Lactate-Guided Therapy in Intensive Care Unit Patients
- (2010) Tim C. Jansen et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy
- (2010) Javid Moslehi et al. CIRCULATION
- Lactate Clearance vs Central Venous Oxygen Saturation as Goals of Early Sepsis TherapyA Randomized Clinical Trial
- (2010) Alan E. Jones JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Chronic Inhibition of Hypoxia-inducible Factor Prolyl 4-hydroxylase Improves Ventricular Performance, Remodeling, and Vascularity After Myocardial Infarction in the Rat
- (2010) Weike Bao et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
- (2010) Y. A. Minamishima et al. SCIENCE
- A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo
- (2009) Y. A. Minamishima et al. MOLECULAR AND CELLULAR BIOLOGY
- Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model
- (2009) W. M. Bernhardt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cystathionine β-synthase as a carbon monoxide-sensitive regulator of bile excretion
- (2008) Tsunehiro Shintani et al. HEPATOLOGY
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
- (2008) William G. Kaelin et al. MOLECULAR CELL
- Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
- (2008) Julián Aragonés et al. NATURE GENETICS
- Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
- (2007) Y. A. Minamishima et al. BLOOD
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More