Small, but powerful and attractive: 19F in biomolecular NMR

The intracellular environment affects protein–protein interactions

(2021) Shannon L. Speer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling

(2021) Shuya Kate Huang et al.   CELL

Advances in the study of GPCRs by 19F NMR

(2021) Louis-Philippe Picard et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Optimizing fluorine labelling for 19F solid-state NMR in oriented biological systems

(2020) Ian M. Robertson et al.   JOURNAL OF BIOMOLECULAR NMR

Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19F NMR of the β1-adrenergic receptor

(2020) J. Niclas Frei et al.   Nature Communications

What does fluorine do to a protein? Thermodynamic, and highly-resolved structural insights into fluorine-labelled variants of the cold shock protein

(2020) Hannah Welte et al.   Scientific Reports

Rapid Quantification of Protein-Ligand Binding via 19F NMR Lineshape Analysis

(2020) Samantha S. Stadmiller et al.   BIOPHYSICAL JOURNAL

19F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2

(2020) Eliza A Ruben et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluorine NMR functional screening: from purified enzymes to human intact living cells

(2020) Claudio Dalvit et al.   JOURNAL OF BIOMOLECULAR NMR

Use of paramagnetic 19F NMR to monitor domain movement in a glutamate transporter homolog

(2020) Yun Huang et al.   Nature Chemical Biology

Design and preparation of the class B G protein‐coupled receptors GLP‐1R and GCGR for 19 F‐NMR studies in solution

(2020) Huixia Wang et al.   FEBS Journal

The Potential of 19F NMR Application in GPCR Biased Drug Discovery

(2020) Xudong Wang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics

(2019) Andras Boeszoermenyi et al.   NATURE METHODS

19F Dynamic Nuclear Polarization at Fast Magic Angle Spinning for NMR of HIV-1 Capsid Protein Assemblies

(2019) Manman Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

19F Dark-State Exchange Saturation Transfer NMR Reveals Reversible Formation of Protein-Specific Large Clusters in High-Concentration Protein Mixtures

(2019) John M. Edwards et al.   ANALYTICAL CHEMISTRY

Positively Charged Tags Impede Protein Mobility in Cells as Quantified by 19F NMR

(2019) Yansheng Ye et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Hybrid-type and two-tetrad antiparallel telomere DNA G-quadruplex structures in living human cells

(2019) Hong-Liang Bao et al.   NUCLEIC ACIDS RESEARCH

Cells, drugs and NMR

(2019) Gregg Siegal et al.   JOURNAL OF MAGNETIC RESONANCE

19F NMR tagging and PRE‐based conformational analysis of intrinsically disordered protein complexes

(2019) Mate Somlyay et al.   CHEMBIOCHEM

19F NMR relaxation studies of fluorosubstituted tryptophans

(2019) Manman Lu et al.   JOURNAL OF BIOMOLECULAR NMR

Fluorinated compounds present opportunities for drug discovery

(2019) Jonathan Clayden   NATURE

Integrated multidisciplinarity in the natural sciences

(2019) Angela M. Gronenborn   JOURNAL OF BIOLOGICAL CHEMISTRY

19F NMR as a Tool for Monitoring Individual Differentially Labeled Proteins in Complex Mixtures

(2018) John M. Edwards et al.   MOLECULAR PHARMACEUTICS

Progress in the synthesis of fluorinated phosphatidylcholines for biological applications

(2018) Marie-Claude Gagnon et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fast Magic Angle Spinning ¹⁹F NMR of HIV-1 Capsid Protein Assemblies

(2018) Mingzhang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ligand-Based Fluorine NMR Screening: Principles and Applications in Drug Discovery Projects

(2018) Claudio Dalvit et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Metastable Contact and Structural Disorder in the Estrogen Receptor Transactivation Domain

(2018) Yi Peng et al.   STRUCTURE

Protein 19F-labeling using transglutaminase for the NMR study of intermolecular interactions

(2017) Yoshikazu Hattori et al.   JOURNAL OF BIOMOLECULAR NMR

Biological applications of xeno nucleic acids

(2017) Kunihiko Morihiro et al.   Molecular BioSystems

Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy

(2017) Hong-Liang Bao et al.   NUCLEIC ACIDS RESEARCH

The application of perfluoroheteroaromatic reagents in the preparation of modified peptide systems

(2017) Diana Gimenez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR

(2017) Matthew R. Elkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HIV-1 p66 homodimeric RT exhibits different conformations in the binding-competent and -incompetent NNRTI site

(2017) Naima G. Sharaf et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

In-cell NMR: a topical review

(2017) Enrico Luchinat et al.   IUCrJ

Conformational Plasticity of the NNRTI-Binding Pocket in HIV-1 Reverse Transcriptase: A Fluorine Nuclear Magnetic Resonance Study

(2016) Naima G. Sharaf et al.   BIOCHEMISTRY

Fluorination methods for drug discovery and development

(2016) Paul Richardson   Expert Opinion on Drug Discovery

19 F Paramagnetic Relaxation Enhancement: A Valuable Tool for Distance Measurements in Proteins

(2015) Elena Matei et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Labeling of Protein Lysine Residues and N-Terminal Amino Groups with Indoles and Indole-Derivatives

(2015) Sacha Thierry Larda et al.   BIOCONJUGATE CHEMISTRY

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integrative, dynamic structural biology at atomic resolution—it's about time

(2015) Henry van den Bedem et al.   NATURE METHODS

Investigating protein conformational energy landscapes and atomic resolution dynamics from NMR dipolar couplings: a review

(2015) Loïc Salmon et al.   REPORTS ON PROGRESS IN PHYSICS

Using 19F NMR to Probe Biological Interactions of Proteins and Peptides

(2014) E. Neil G. Marsh et al.   ACS Chemical Biology

Live Cell NMR

(2014) Darón I. Freedberg et al.   Annual Review of Biophysics

Conformational Selection and Functional Dynamics of Calmodulin: A 19F Nuclear Magnetic Resonance Study

(2014) Joshua Hoang et al.   BIOCHEMISTRY

Resolution of Oligomeric Species during the Aggregation of Aβ1–40 Using 19F NMR

(2013) Yuta Suzuki et al.   BIOCHEMISTRY

Quantitative comparison of protein dynamics in live cells and in vitro by in-cell 19F-NMR

(2013) Yousuke Takaoka et al.   CHEMICAL COMMUNICATIONS

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

19F NMR Spectroscopy as a Probe of Cytoplasmic Viscosity and Weak Protein Interactions in Living Cells

(2013) Yansheng Ye et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorinated Carbohydrates as Lectin Ligands: Dissecting Glycan-Cyanovirin Interactions by Using19F NMR Spectroscopy

(2013) Elena Matei et al.   CHEMISTRY-A EUROPEAN JOURNAL

Integrative Structural Biology

(2013) A. B. Ward et al.   SCIENCE

Simple and inexpensive incorporation of 19F-Tryptophan for protein NMR spectroscopy

(2012) Peter B. Crowley et al.   CHEMICAL COMMUNICATIONS

Current applications of 19F NMR to studies of protein structure and dynamics

(2011) Julianne L. Kitevski-LeBlanc et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Site-specific19F NMR chemical shift and side chain relaxation analysis of a membrane protein labeled with an unnatural amino acid

(2010) Pan Shi et al.   PROTEIN SCIENCE

19F NMR studies of α-synuclein-membrane interactions

(2010) Gui-Fang Wang et al.   PROTEIN SCIENCE

19F NMR Studies of α-Synuclein Conformation and Fibrillation

(2009) Conggang Li et al.   BIOCHEMISTRY

Ligand-directed tosyl chemistry for protein labeling in vivo

(2009) Shinya Tsukiji et al.   Nature Chemical Biology

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

In vivoIncorporation of Unnatural Amino Acids to Probe Structure, Dynamics, and Ligand Binding in a Large Protein by Nuclear Magnetic Resonance Spectroscopy

(2008) Susan E. Cellitti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In situ observation of protein phosphorylation by high-resolution NMR spectroscopy

(2008) Philipp Selenko et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS