Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling

Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19F NMR of the β1-adrenergic receptor

(2020) J. Niclas Frei et al.   Nature Communications

Impact of GPCR Structures on Drug Discovery

(2020) Miles Congreve et al.   CELL

Probing the correlation between ligand efficacy and conformational diversity at the α1A-adrenoreceptor reveals allosteric coupling of its microswitches

(2020) Feng-Jie Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Focusing on Adenosine Receptors as a Potential Targeted Therapy in Human Diseases

(2020) Wiwin Is Effendi et al.   Cells

Adenosine A2A Receptor Antagonists for Cancer Immunotherapy

(2020) Fazhi Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of a D2 dopamine receptor–G-protein complex in a lipid membrane

(2020) Jie Yin et al.   NATURE

Dynamic Role of the G Protein in Stabilizing the Active State of the Adenosine A2A Receptor

(2019) Sangbae Lee et al.   STRUCTURE

Structural Insights into the Process of GPCR-G Protein Complex Formation

(2019) Xiangyu Liu et al.   CELL

Assembly of a GPCR-G Protein Complex

(2019) Yang Du et al.   CELL

G-protein βγ subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling

(2019) Alan V. Smrcka et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Molecular Basis of G Protein–Coupled Receptor Activation

(2018) William I. Weis et al.   Annual Review of Biochemistry

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A 2A Adenosine Receptor

(2018) Matthew T. Eddy et al.   CELL

A2A adenosine receptor agonists and their potential therapeutic applications. An update

(2018) Angel Guerrero   CURRENT MEDICINAL CHEMISTRY

Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations

(2018) Libin Ye et al.   Nature Communications

Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

(2018) Javier García-Nafría et al.   eLife

Development of Adenosine A2A Receptor Antagonists for the Treatment of Parkinson’s Disease: A Recent Update and Challenge

(2018) Jiyue Zheng et al.   ACS Chemical Neuroscience

A2A adenosine receptor functional states characterized by 19F-NMR

(2018) Lukas Sušac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule analysis of ligand efficacy in β2AR–G-protein activation

(2017) G. Glenn Gregorio et al.   NATURE

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Conformational equilibria of light-activated rhodopsin in nanodiscs

(2017) Ned Van Eps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor

(2017) Andras S. Solt et al.   Nature Communications

Ligand modulation of sidechain dynamics in a wild-type human GPCR

(2017) Lindsay D Clark et al.   eLife

Structure network analysis to gain insights into GPCR function

(2016) Francesca Fanelli et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Functional Modulation of a G Protein-Coupled Receptor Conformational Landscape in a Lipid Bilayer

(2016) Marina Casiraghi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Erratum: Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor

(2016) Shin Isogai et al.   NATURE

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

(2016) Libin Ye et al.   NATURE

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

(2016) Dean P. Staus et al.   NATURE

A Homogenous Bioluminescent System for Measuring GTPase, GTPase Activating Protein, and Guanine Nucleotide Exchange Factor Activities

(2015) Subhanjan Mondal et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in 19F NMR studies of proteins

(2015) Libin Ye et al.   JOURNAL OF BIOMOLECULAR NMR

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Propagation of conformational changes during μ-opioid receptor activation

(2015) Rémy Sounier et al.   NATURE

Functional Dynamics of Deuterated β2-Adrenergic Receptor in Lipid Bilayers Revealed by NMR Spectroscopy

(2014) Yutaka Kofuku et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Conserved Phenylalanine as a Relay between the α5 Helix and the GDP Binding Region of Heterotrimeric GiProtein α Subunit

(2014) Ali I. Kaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Dynamic Process of β2-Adrenergic Receptor Activation

(2013) Rie Nygaard et al.   CELL

Adenosine A2A Receptor as a Drug Discovery Target

(2013) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimized Phospholipid Bilayer Nanodiscs Facilitate High-Resolution Structure Determination of Membrane Proteins

(2013) Franz Hagn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Eukaryotic G Protein Signaling Evolved to Require G Protein-Coupled Receptors for Activation

(2013) W. Bradford et al.   Science Signaling

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Conformational Dynamics of Single G Protein-Coupled Receptors in Solution

(2011) Samuel Bockenhauer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Activation mechanism of the  2-adrenergic receptor

(2011) R. O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

(2011) Andrew S. Doré et al.   STRUCTURE

Ligand-Induced Modulation of the Free-Energy Landscape of G Protein-Coupled Receptors Explored by Adaptive Biasing Techniques

(2011) Davide Provasi et al.   PLoS Computational Biology

Functional Role of the “Ionic Lock”—An Interhelical Hydrogen-Bond Network in Family A Heptahelical Receptors

(2008) Reiner Vogel et al.   JOURNAL OF MOLECULAR BIOLOGY

Activation of G Protein–Coupled Receptors: Beyond Two-State Models and Tertiary Conformational Changes

(2007) Paul S.-H. Park et al.   Annual Review of Pharmacology and Toxicology

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY