Design and preparation of the class B G protein‐coupled receptors GLP‐1R and GCGR for 19 F‐NMR studies in solution

Activation of the GLP-1 receptor by a non-peptidic agonist

(2020) Peishen Zhao et al.   NATURE

Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide

(2020) Rulue Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of Gs and Gi recognition by the human glucagon receptor

(2020) Anna Qiao et al.   SCIENCE

Full-length human GLP-1 receptor structure without orthosteric ligands

(2020) Fan Wu et al.   Nature Communications

Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G protein–coupled receptors

(2019) Dean P Staus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutagenesis facilitated crystallization of GLP-1R

(2019) Yueming Xu et al.   IUCrJ

Structure of the glucagon receptor in complex with a glucagon analogue

(2018) Haonan Zhang et al.   NATURE

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

(2018) Yi-Lynn Liang et al.   NATURE

GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

(2018) Ichio Shimada et al.   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of the GLP-1 receptor bound to a peptide agonist

(2017) Ali Jazayeri et al.   NATURE

Structure of the full-length glucagon class B G-protein-coupled receptor

(2017) Haonan Zhang et al.   NATURE

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

(2017) Gaojie Song et al.   NATURE

Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

(2017) Yan Zhang et al.   NATURE

The New Biology and Pharmacology of Glucagon

(2017) T. D. Müller et al.   PHYSIOLOGICAL REVIEWS

Extra-helical binding site of a glucagon receptor antagonist

(2016) Ali Jazayeri et al.   NATURE

In-Membrane Chemical Modification (IMCM) for Site-Specific Chromophore Labeling of GPCRs

(2015) Lukas Sušac et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of class B GPCR corticotropin-releasing factor receptor 1

(2013) Kaspar Hollenstein et al.   NATURE

Structure of the human glucagon class B G-protein-coupled receptor

(2013) Fai Yiu Siu et al.   NATURE

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

(2013) D. Wootten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

(2010) Michael P. Bokoch et al.   NATURE

The metabolic actions of glucagon revisited

(2010) Kirk M. Habegger et al.   Nature Reviews Endocrinology

Membrane protein assembly into Nanodiscs

(2009) Timothy H. Bayburt et al.   FEBS LETTERS

Cardioprotective and Vasodilatory Actions of Glucagon-Like Peptide 1 Receptor Are Mediated Through Both Glucagon-Like Peptide 1 Receptor–Dependent and –Independent Pathways

(2008) Kiwon Ban et al.   CIRCULATION