Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19F NMR of the β1-adrenergic receptor
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Conformational plasticity of ligand-bound and ternary GPCR complexes studied by 19F NMR of the β1-adrenergic receptor
Authors
Keywords
-
Journal
Nature Communications
Volume 11, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-02-03
DOI
10.1038/s41467-020-14526-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Molecular basis for high-affinity agonist binding in GPCRs
- (2019) Tony Warne et al. SCIENCE
- The role of NMR spectroscopy in mapping the conformational landscape of GPCRs
- (2019) Mark J Bostock et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- The Molecular Basis of G Protein–Coupled Receptor Activation
- (2018) William I. Weis et al. Annual Review of Biochemistry
- Structural Basis for G Protein–Coupled Receptor Signaling
- (2018) Sarah C. Erlandson et al. Annual Review of Biophysics
- Recent advances in the determination of G protein-coupled receptor structures
- (2018) David M Thal et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?
- (2018) Krishna Sriram et al. MOLECULAR PHARMACOLOGY
- Structure and dynamics of GPCR signaling complexes
- (2018) Daniel Hilger et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanistic insights into allosteric regulation of the A2A adenosine G protein-coupled receptor by physiological cations
- (2018) Libin Ye et al. Nature Communications
- Structure and dynamics of GPCR signaling complexes
- (2018) Daniel Hilger et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural insights into G-protein-coupled receptor allostery
- (2018) David M. Thal et al. NATURE
- GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures
- (2018) Ichio Shimada et al. NATURE REVIEWS DRUG DISCOVERY
- A2A adenosine receptor functional states characterized by 19F-NMR
- (2018) Lukas Sušac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Trends in GPCR drug discovery: new agents, targets and indications
- (2017) Alexander S. Hauser et al. NATURE REVIEWS DRUG DISCOVERY
- Insight into partial agonism by observing multiple equilibria for ligand-bound and Gs-mimetic nanobody-bound β1-adrenergic receptor
- (2017) Andras S. Solt et al. Nature Communications
- GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling
- (2016) Alex R.B. Thomsen et al. CELL
- GPCR Dynamics: Structures in Motion
- (2016) Naomi R. Latorraca et al. CHEMICAL REVIEWS
- Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor
- (2016) Shin Isogai et al. NATURE
- Activation of the A2A adenosine G-protein-coupled receptor by conformational selection
- (2016) Libin Ye et al. NATURE
- Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region
- (2016) A. J. Venkatakrishnan et al. NATURE
- β 2 -Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop
- (2016) Matthew T. Eddy et al. STRUCTURE
- Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling
- (2015) Aashish Manglik et al. CELL
- A comparison of chemical shift sensitivity of trifluoromethyl tags: optimizing resolution in 19F NMR studies of proteins
- (2015) Libin Ye et al. JOURNAL OF BIOMOLECULAR NMR
- The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin
- (2014) Aashish Manglik et al. CURRENT OPINION IN CELL BIOLOGY
- An exact solution for R2,eff in CPMG experiments in the case of two site chemical exchange
- (2014) Andrew J. Baldwin JOURNAL OF MAGNETIC RESONANCE
- The Dynamic Process of β2-Adrenergic Receptor Activation
- (2013) Rie Nygaard et al. CELL
- Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs
- (2013) Tatiana Didenko et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- The Role of Ligands on the Equilibria Between Functional States of a G Protein-Coupled Receptor
- (2013) Tae Hun Kim et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structural Features for Functional Selectivity at Serotonin Receptors
- (2013) D. Wacker et al. SCIENCE
- Agonist-bound structures of G protein-coupled receptors
- (2012) Guillaume Lebon et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Biased Signaling Pathways in 2-Adrenergic Receptor Characterized by 19F-NMR
- (2012) J. J. Liu et al. SCIENCE
- Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol
- (2012) Tony Warne et al. STRUCTURE
- Efficacy of the β2-adrenergic receptor is determined by conformational equilibrium in the transmembrane region
- (2012) Yutaka Kofuku et al. Nature Communications
- Nanobody stabilization of G protein-coupled receptor conformational states
- (2011) Jan Steyaert et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor
- (2011) Søren G. F. Rasmussen et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- Speciation with gene flow on Lord Howe Island
- (2011) Alexander S. T. Papadopulos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Current applications of 19F NMR to studies of protein structure and dynamics
- (2011) Julianne L. Kitevski-LeBlanc et al. PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
- Ligand-directed signalling at β-adrenoceptors
- (2010) Bronwyn A. Evans et al. BRITISH JOURNAL OF PHARMACOLOGY
- The structure and function of G-protein-coupled receptors
- (2009) Daniel M. Rosenbaum et al. NATURE
- Conformational Rearrangements and Signaling Cascades Involved in Ligand-Biased Mitogen-Activated Protein Kinase Signaling through the 1-Adrenergic Receptor
- (2008) S. Galandrin et al. MOLECULAR PHARMACOLOGY
- -Blockers alprenolol and carvedilol stimulate -arrestin-mediated EGFR transactivation
- (2008) I.-M. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation