Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins

Absence of ApoE Upregulates Murine Brain ApoD and ABCA1 Levels, But Does Not Affect Brain Sterol Levels, While Human ApoE3 and Human ApoE4 Upregulate Brain Cholesterol Precursor Levels

(2017) Paula J. Jansen et al.   JOURNAL OF ALZHEIMERS DISEASE

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Reconstituted high-density lipoproteins acutely reduce soluble brain Aβ levels in symptomatic APP/PS1 mice

(2016) Jérôme Robert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Relation between plasma and brain lipids

(2016) Cheryl L. Wellington et al.   CURRENT OPINION IN LIPIDOLOGY

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of preβ-1 HDL In Vitro

(2015) Anouar Hafiane et al.   PLoS One

HDL and cholesterol handling in the brain

(2014) C. Vitali et al.   CARDIOVASCULAR RESEARCH

High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

(2014) Sophie Stukas et al.   Cell Metabolism

Amyloid-β Pathology andAPOEGenotype Modulate Retinoid X Receptor Agonist Activityin Vivo

(2014) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease

(2014) Judes Poirier et al.   NEUROBIOLOGY OF AGING

ATP-binding cassette transporter A1: From metabolism to neurodegeneration

(2014) Radosveta Koldamova et al.   NEUROBIOLOGY OF DISEASE

Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus

(2014) Sophie Stukas et al.   Journal of the American Heart Association

Molecular Mechanisms Responsible for the Differential Effects of ApoE3 and ApoE4 on Plasma Lipoprotein–Cholesterol Levels

(2013) Hui Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Levels of Soluble Apolipoprotein E/Amyloid-β (Aβ) Complex Are Reduced and Oligomeric Aβ Increased withAPOE4and Alzheimer Disease in a Transgenic Mouse Model and Human Samples

(2013) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

(2013) Jason D Ulrich et al.   Molecular Neurodegeneration

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

(2013) Ori Liraz et al.   Molecular Neurodegeneration

Cerebrovascular Effects of Apolipoprotein E

(2013) Berislav V. Zlokovic   JAMA Neurology

Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides

(2013) Angela J. Hanson et al.   JAMA Neurology

Apolipoprotein A–V modulates multiple atherogenic mechanisms in a mouse model of disturbed clearance of triglyceride-rich lipoproteins

(2012) Itamar Grosskopf et al.   ATHEROSCLEROSIS

New insights into the determination of HDL structure by apolipoproteins

(2012) Michael C. Phillips   JOURNAL OF LIPID RESEARCH

The Role of Clusterin in Alzheimer’s Disease: Pathways, Pathogenesis, and Therapy

(2012) Jin-Tai Yu et al.   MOLECULAR NEUROBIOLOGY

The Effects of Apolipoproteins E3 and E4 on the Transforming Growth Factor-ß System in Targeted Replacement Mice

(2012) Adi Haas et al.   Neurodegenerative Diseases

Apolipoprotein E4 Is Deficient in Inducing Macrophage ABCA1 Expression and Stimulating the Sp1 Signaling Pathway

(2012) Emmanuel Ugochukwu Okoro et al.   PLoS One

Formation and function of apolipoprotein E-containing lipoproteins in the nervous system

(2010) Jean E. Vance et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Apolipoproteins in the brain: implications for neurological and psychiatric disorders

(2010) David A Elliott et al.   Clinical Lipidology

A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice

(2010) John K. Bielicki et al.   JOURNAL OF LIPID RESEARCH

Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass

(2010) Marius R Robciuc et al.   Lipids in Health and Disease

The cell cholesterol exporter ABCA1 as a protector from cardiovascular disease and diabetes

(2009) Chongren Tang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Structural Characterization of Clusterin-Chaperone Client Protein Complexes

(2009) Amy R. Wyatt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ApoE4-dependent Aβ-mediated neurodegeneration is associated with inflammatory activation in the hippocampus but not the septum

(2009) Haim Belinson et al.   JOURNAL OF NEURAL TRANSMISSION

Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture

(2009) Hirohisa Minagawa et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Activation of the Amyloid Cascade in Apolipoprotein E4 Transgenic Mice Induces Lysosomal Activation and Neurodegeneration Resulting in Marked Cognitive Deficits

(2008) H. Belinson et al.   JOURNAL OF NEUROSCIENCE