Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer’s disease–associated genes
出版年份 2021 全文链接
标题
Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer’s disease–associated genes
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 118, Issue 52, Pages e2112095118
出版商
Proceedings of the National Academy of Sciences
发表日期
2021-12-24
DOI
10.1073/pnas.2112095118
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Astrocytes in stress accumulate lipid droplets
- (2021) Tina Smolič et al. GLIA
- Recent insights into the role of glia and oxidative stress in Alzheimer's disease gained from Drosophila
- (2021) Lindsey D. Goodman et al. CURRENT OPINION IN NEUROBIOLOGY
- Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
- (2020) Julia Marschallinger et al. NATURE NEUROSCIENCE
- BRAIN LIPID PEROXIDATION AND ALZHEIMER DISEASE: SYNERGY BETWEEN THE BUTTERFIELD AND MATTSON LABORATORIES
- (2020) D. Allan Butterfield AGEING RESEARCH REVIEWS
- The MUC6/AP2A2 Locus and Its Relevance to Alzheimer’s Disease: A Review
- (2020) Peter T Nelson et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Association of genetic variants of ABCA1 with susceptibility to dementia: (SADEM study)
- (2020) Juárez-Cedillo Teresa et al. METABOLIC BRAIN DISEASE
- Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms
- (2020) Hyung-lok Chung et al. NEURON
- Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease
- (2020) Ruinan Shen et al. Translational Neurodegeneration
- ApoE Lipidation as a Therapeutic Target in Alzheimer’s Disease
- (2020) Maria Fe Lanfranco et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- APOE4 impairs neuron‐astrocyte coupling of fatty acid metabolism
- (2020) Guoyuan Qi et al. Alzheimers & Dementia
- Alzheimer's disease GWAS weighted by multi‐omics and endophenotypes identifies novel risk loci
- (2020) Yiyi Ma et al. Alzheimers & Dementia
- Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
- (2019) Iris E. Jansen et al. NATURE GENETICS
- Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities
- (2019) Alireza Nazarian et al. Alzheimers Research & Therapy
- Prediction of Alzheimer’s Disease-Associated Genes by Integration of GWAS Summary Data and Expression Data
- (2019) Sicheng Hao et al. Frontiers in Genetics
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
- (2019) Brian W. Kunkle et al. NATURE GENETICS
- CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway
- (2019) Kotaro Furusawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oxidative Stress: A Key Modulator in Neurodegenerative Diseases
- (2019) Anju Singh et al. MOLECULES
- Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors
- (2019) Zoë P. Van Acker et al. Molecular Neurodegeneration
- Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project
- (2019) Sonia Moreno-Grau et al. Alzheimers & Dementia
- cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis
- (2019) Shamsideen A. Ojelade et al. Cell Reports
- Lipid peroxidation biomarkers correlation with medial temporal atrophy in early Alzheimer Disease
- (2019) Carmen Peña-Bautista et al. NEUROCHEMISTRY INTERNATIONAL
- Neuroimaging of Diseases Causing Dementia
- (2019) Joseph C. Masdeu NEUROLOGIC CLINICS
- ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer’s disease
- (2019) Ya-Ting Chang et al. Alzheimers Research & Therapy
- Markers of oxidative damage to lipids, nucleic acids and proteins and antioxidant enzymes activities in Alzheimer's disease brain: A meta-analysis in human pathological specimens
- (2018) Matthew Zabel et al. FREE RADICAL BIOLOGY AND MEDICINE
- Oxidative Stress, Amyloid-β Peptide, and Altered Key Molecular Pathways in the Pathogenesis and Progression of Alzheimer’s Disease
- (2018) D. Allan Butterfield et al. JOURNAL OF ALZHEIMERS DISEASE
- Mechanisms of clathrin-mediated endocytosis
- (2018) Marko Kaksonen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- ABCA1 rs2230805 and rs2230806 common gene variants are associated with Alzheimer’s disease
- (2018) Ágnes Fehér et al. NEUROSCIENCE LETTERS
- Synaptic Vesicle Endocytosis in Different Model Systems
- (2018) Quan Gan et al. Frontiers in Cellular Neuroscience
- A gene-specific T2A-GAL4 library for Drosophila
- (2018) Pei-Tseng Lee et al. eLife
- Dynamic clustering of dynamin-amphiphysin helices regulates membrane constriction and fission coupled with GTP hydrolysis
- (2018) Tetsuya Takeda et al. eLife
- Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
- (2018) C. Cheignon et al. Redox Biology
- Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina
- (2018) Daan M. Van Den Brink et al. PLoS Genetics
- Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila
- (2018) Scott Barish et al. PLoS Genetics
- Recycling the LDL receptor to combat atherosclerosis
- (2018) Dyonne Vos et al. Aging-US
- Sphingolipids in the Pathogenesis of Parkinson’s Disease and Parkinsonism
- (2018) Guang Lin et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Dietary Modulation of Oxidative Stress in Alzheimer’s Disease
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Alzheimer’s Disease Genetics and ABCA7 Splicing
- (2017) Jared B. Vasquez et al. JOURNAL OF ALZHEIMERS DISEASE
- Role of LRP1 in the pathogenesis of Alzheimer’s disease: evidence from clinical and preclinical studies
- (2017) Mitsuru Shinohara et al. JOURNAL OF LIPID RESEARCH
- Brain aging and neurodegeneration: from a mitochondrial point of view
- (2017) Amandine Grimm et al. JOURNAL OF NEUROCHEMISTRY
- Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome
- (2017) Michele Ferrari et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease
- (2017) Courtney Lane-Donovan et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-β42 in APOE Knock-in and Knock-out Mice
- (2017) Matthew J. Sharman et al. JOURNAL OF ALZHEIMERS DISEASE
- The influence of common free radicals and antioxidants on development of Alzheimer’s Disease
- (2016) Karolina A. Wojtunik-Kulesza et al. BIOMEDICINE & PHARMACOTHERAPY
- The Cellular Phase of Alzheimer’s Disease
- (2016) Bart De Strooper et al. CELL
- Bin1 and CD2AP polarise the endocytic generation of beta‐amyloid
- (2016) Florent Ubelmann et al. EMBO REPORTS
- ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies
- (2016) Anat Boehm-Cagan et al. JOURNAL OF ALZHEIMERS DISEASE
- The Adaptor Protein CD2AP Is a Coordinator of Neurotrophin Signaling-Mediated Axon Arbor Plasticity
- (2016) B. J. Harrison et al. JOURNAL OF NEUROSCIENCE
- Influence of four polymorphisms in ABCA1 and PTGS2 genes on risk of Alzheimer’s disease: a meta-analysis
- (2016) Qicong Chen et al. NEUROLOGICAL SCIENCES
- Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation
- (2016) Tobi Van den Bossche et al. NEUROLOGY
- Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse
- (2016) Ye Zhang et al. NEURON
- Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins
- (2016) Anat Boehm-Cagan et al. PLoS One
- Hypoxia as a therapy for mitochondrial disease
- (2016) I. H. Jain et al. SCIENCE
- Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease
- (2016) Amit K. Chouhan et al. Acta Neuropathologica Communications
- Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update
- (2015) Melissa A. Bradley-Whitman et al. ARCHIVES OF TOXICOLOGY
- Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis
- (2015) Celeste M. Karch et al. BIOLOGICAL PSYCHIATRY
- Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration
- (2015) Lucy Liu et al. CELL
- Lipophilicity of amyloid β-peptide 12–28 and 25–35 to unravel their ability to promote hydrophobic and electrostatic interactions
- (2015) G. Ermondi et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease
- (2015) Stacy Steinberg et al. NATURE GENETICS
- DrosophilaCentral Nervous System Glia
- (2015) Marc R. Freeman Cold Spring Harbor Perspectives in Biology
- Drosophila Lipophorin Receptors Recruit the Lipoprotein LTP to the Plasma Membrane to Mediate Lipid Uptake
- (2015) Míriam Rodríguez-Vázquez et al. PLoS Genetics
- Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of preβ-1 HDL In Vitro
- (2015) Anouar Hafiane et al. PLoS One
- APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease
- (2014) Daniel M. Michaelson Alzheimers & Dementia
- An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
- (2014) Y. Zhang et al. JOURNAL OF NEUROSCIENCE
- Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications
- (2014) Joanne Walsh et al. Journal of Proteomics
- ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?
- (2014) Takahisa Kanekiyo et al. NEURON
- The Use of Pharmacological Retromer Chaperones in Alzheimer’s Disease and other Endosomal-related Disorders
- (2014) Diego E. Berman et al. Neurotherapeutics
- The Retromer Complex Is Required for Rhodopsin Recycling and Its Loss Leads to Photoreceptor Degeneration
- (2014) Shiuan Wang et al. PLOS BIOLOGY
- Amyloid-β and Tau
- (2014) George S. Bloom JAMA Neurology
- Oxidative damage to macromolecules in human Parkinson disease and the rotenone model
- (2013) Laurie H. Sanders et al. FREE RADICAL BIOLOGY AND MEDICINE
- Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
- (2013) J Chapuis et al. MOLECULAR PSYCHIATRY
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- (2013) Jean-Charles Lambert et al. NATURE GENETICS
- ApoE influences amyloid- (A ) clearance despite minimal apoE/A association in physiological conditions
- (2013) P. B. Verghese et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Role of ABC transporters in lipid transport and human disease
- (2013) Elizabeth J. Tarling et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Probing Mechanisms That Underlie Human Neurodegenerative Diseases inDrosophila
- (2012) M. Jaiswal et al. Annual Review of Genetics
- A constant and similar assembly defect of mitochondrial respiratory chain complex I allows rapid identification of NDUFS4 mutations in patients with Leigh syndrome
- (2012) Z. Assouline et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Fatal breathing dysfunction in a mouse model of Leigh syndrome
- (2012) Albert Quintana et al. JOURNAL OF CLINICAL INVESTIGATION
- Fiji: an open-source platform for biological-image analysis
- (2012) Johannes Schindelin et al. NATURE METHODS
- Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex
- (2012) Gerard M J Beaudoin et al. Nature Protocols
- Identification of Alzheimer disease-associated variants in genes that regulate retromer function
- (2012) Badri N. Vardarajan et al. NEUROBIOLOGY OF AGING
- Antioxidant Pathways in Alzheimers Disease: Possibilities of Intervention
- (2011) J. Vina et al. CURRENT PHARMACEUTICAL DESIGN
- Lipid peroxidation and neurodegenerative disease
- (2011) Tanea T. Reed FREE RADICAL BIOLOGY AND MEDICINE
- Extending life span by increasing oxidative stress
- (2011) Michael Ristow et al. FREE RADICAL BIOLOGY AND MEDICINE
- Linking lipids to Alzheimer's disease: cholesterol and beyond
- (2011) Gilbert Di Paolo et al. NATURE REVIEWS NEUROSCIENCE
- Prevalence of Apolipoprotein E4 Genotype and Homozygotes (APOE e4/4) among Patients Diagnosed with Alzheimer’s Disease: A Systematic Review and Meta-Analysis
- (2011) Alex Ward et al. NEUROEPIDEMIOLOGY
- Distribution and Expression of Picalm in Alzheimer Disease
- (2010) Shabnam Baig et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression
- (2010) Melissa A. Bradley et al. NEUROBIOLOGY OF AGING
- Apolipoprotein E receptors in the nervous system
- (2009) Joachim Herz CURRENT OPINION IN LIPIDOLOGY
- Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
- (2008) Suzanne E. Wahrle et al. JOURNAL OF CLINICAL INVESTIGATION
- Engrailed Homeobox Genes Determine the Organization of Purkinje Cell Sagittal Stripe Gene Expression in the Adult Cerebellum
- (2008) R. V. Sillitoe et al. JOURNAL OF NEUROSCIENCE
- Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and A accumulation
- (2008) A. Muhammad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started