Recent insights into the role of glia and oxidative stress in Alzheimer's disease gained from Drosophila

Alpha‐lipoic acid ameliorates tauopathy‐induced oxidative stress, apoptosis, and behavioral deficits through the balance of DIAP1/DrICE ratio and redox homeostasis: Age is a determinant factor

(2021) Elahe Zarini-Gakiye et al.   METABOLIC BRAIN DISEASE

Tau strains shape disease

(2021) Jaime Vaquer-Alicea et al.   ACTA NEUROPATHOLOGICA

Hedgehog Signaling Modulates Glial Proteostasis and Lifespan

(2020) Andrew Rallis et al.   Cell Reports

Glia in neurodegeneration: Drivers of disease or along for the ride?

(2020) Amy J. Gleichman et al.   NEUROBIOLOGY OF DISEASE

Early Mitochondrial Fragmentation and Dysfunction in a Drosophila Model for Alzheimer’s Disease

(2020) Xingjun Wang et al.   MOLECULAR NEUROBIOLOGY

Suppression of tau‐induced phenotypes by vitamin E demonstrates the dissociation of oxidative stress and phosphorylation in mechanisms of tau toxicity

(2020) Catherine M. Cowan et al.   JOURNAL OF NEUROCHEMISTRY

Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model

(2020) Kelly M. Lohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity

(2020) Victor Girard et al.   Scientific Reports

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Unraveling Novel Mechanisms of Neurodegeneration Through a Large-Scale Forward Genetic Screen in Drosophila

(2019) Samantha L. Deal et al.   Frontiers in Genetics

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Biotin in metabolism, gene expression, and human disease

(2019) Alfonso León‐Del‐Río   JOURNAL OF INHERITED METABOLIC DISEASE

Is CSF SOD1 a Biomarker of Tau but not Amyloid Induced Neurodegeneration in Alzheimer's Disease?

(2019) Kelsey E. McLimans et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

(2019) Judit M. Perez Ortiz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation

(2019) Gaynor A. Smith et al.   NEURON

Association of Early-Onset Alzheimer Disease With Elevated Low-density Lipoprotein Cholesterol Levels and Rare Genetic Coding Variants of APOB

(2019) Thomas S. Wingo et al.   JAMA Neurology

Vitamin E and Alzheimer’s disease: what do we know so far?

(2019) Declan Browne et al.   Clinical Interventions in Aging

V232M substitution restricts a distinct O-glycosylation of PLD3 and its neuroprotective function

(2019) Atanas Vladimirov Demirev et al.   NEUROBIOLOGY OF DISEASE

Beta-Amyloid Increases the Expression Levels of Tid1 Responsible for Neuronal Cell Death and Amyloid Beta Production

(2019) Chunyu Zhou et al.   MOLECULAR NEUROBIOLOGY

Lipid peroxidation biomarkers correlation with medial temporal atrophy in early Alzheimer Disease

(2019) Carmen Peña-Bautista et al.   NEUROCHEMISTRY INTERNATIONAL

Mammalian phospholipase D: Function, and therapeutics

(2019) M.I. McDermott et al.   PROGRESS IN LIPID RESEARCH

Mitochondrial dysfunction and neurodegenerative proteinopathies: mechanisms and prospects for therapeutic intervention

(2018) Thomas Briston et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Experimental Induction of Type 2 Diabetes in Aging-Accelerated Mice Triggered Alzheimer-Like Pathology and Memory Deficits

(2018) Jogender Mehla et al.   JOURNAL OF ALZHEIMERS DISEASE

The Emerging Role of Glutathione in Alzheimer's Disease

(2018) Sumiti Saharan et al.   JOURNAL OF ALZHEIMERS DISEASE

A Multi-Center Human Brain Glutathione Conformation Study from Magnetic Resonance Spectroscopy

(2018) Deepika Shukla et al.   JOURNAL OF ALZHEIMERS DISEASE

Changes in Glutathione Redox Potential Are Linked to Aβ42-Induced Neurotoxicity

(2018) Zeenna A. Stapper et al.   Cell Reports

Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

(2018) Daan M. Van Den Brink et al.   PLoS Genetics

Differential protective effects of connective tissue growth factor against Aβ neurotoxicity on neurons and glia

(2017) Cheng-Ning Yang et al.   HUMAN MOLECULAR GENETICS

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

(2017) Seung Hyun Baek et al.   JOURNAL OF NEUROSCIENCE

Glial Draper Rescues Aβ Toxicity in aDrosophilaModel of Alzheimer's Disease

(2017) Arpita Ray et al.   JOURNAL OF NEUROSCIENCE

PLD3 gene and processing of APP

(2017) Pietro Fazzari et al.   NATURE

Drosophilatools and assays for the study of human diseases

(2016) Berrak Ugur et al.   Disease Models & Mechanisms

Expression of the alternative oxidase mitigates beta-amyloid production and toxicity in model systems

(2016) Riyad El-Khoury et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic changes may precede proteostatic dysfunction in a  Drosophila model of amyloid beta peptide toxicity

(2016) Stanislav Ott et al.   NEUROBIOLOGY OF AGING

A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian Disorders

(2016) Xuting Wang et al.   Cell Reports

Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update

(2015) Melissa A. Bradley-Whitman et al.   ARCHIVES OF TOXICOLOGY

Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration

(2015) Lucy Liu et al.   CELL

Drosophilaas anIn VivoModel for Human Neurodegenerative Disease

(2015) Leeanne McGurk et al.   GENETICS

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

Diabetes and Alzheimer Disease, Two Overlapping Pathologies with the Same Background: Oxidative Stress

(2015) Sergio Rosales-Corral et al.   Oxidative Medicine and Cellular Longevity

Drosophilaas anIn VivoModel for Human Neurodegenerative Disease

(2015) Leeanne McGurk et al.   GENETICS

Association Between Alzheimer Dementia Mortality Rate and Altitude in California Counties

(2015) Stephen Thielke et al.   JAMA Psychiatry

Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer’s disease

(2013) Carlos Cruchaga et al.   NATURE

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Antioxidant clinical trials in mild cognitive impairment and Alzheimer's disease

(2011) Patrizia Mecocci et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

In Vivo Mapping of Hydrogen Peroxide and Oxidized Glutathione Reveals Chemical and Regional Specificity of Redox Homeostasis

(2011) Simone C. Albrecht et al.   Cell Metabolism

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Power tools for gene expression and clonal analysis in Drosophila

(2011) Alberto del Valle Rodríguez et al.   NATURE METHODS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS