Coffee Leaves: An Upcoming Novel Food?

Phylogenomic analysis clarifies the evolutionary origin of Coffea arabica

(2020) Yves Bawin et al.   Journal of Systematics and Evolution

Green coffee infusion as a source of caffeine and chlorogenic acid

(2019) Lukas Macheiner et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Polyphenol Extracts from Three Colombian Passifloras (Passion Fruits) Prevent Inflammation-Induced Barrier Dysfunction of Caco-2 Cells

(2019) Juan Carlos Carmona-Hernandez et al.   MOLECULES

Dietary Antioxidants in Coffee Leaves: Impact of Botanical Origin and Maturity on Chlorogenic Acids and Xanthones

(2019) Ângelo Monteiro et al.   Antioxidants

Chlorogenic acid (CGA): A pharmacological review and call for further research

(2018) Muhammad Naveed et al.   BIOMEDICINE & PHARMACOTHERAPY

Effects of processing method and age of leaves on phytochemical profiles and bioactivity of coffee leaves

(2018) Xiu-Min Chen et al.   FOOD CHEMISTRY

Metabolomics fingerprint of coffee species determined by untargeted-profiling study using LC-HRMS

(2018) Florence Souard et al.   FOOD CHEMISTRY

A review on coffee leaves: Phytochemicals, bioactivities and applications

(2018) Xiumin Chen   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Nutraceutical compounds: Echinoids, flavonoids, xanthones and caffeine identified and quantitated in the leaves of Coffea arabica trees from three regions of Brazil

(2018) Ricardo Farias de Almeida et al.   FOOD RESEARCH INTERNATIONAL

Antioxidant extracts of coffee leaves and its active ingredient 5-caffeoylquinic acid reduce chemically-induced inflammation in mice

(2018) Luciana Segheto et al.   INDUSTRIAL CROPS AND PRODUCTS

Cafestol, a Bioactive Substance in Coffee, Has Antidiabetic Properties in KKAy Mice

(2017) Fredrik Brustad Mellbye et al.   JOURNAL OF NATURAL PRODUCTS

Mangiferin: a natural miracle bioactive compound against lifestyle related disorders

(2017) Muhammad Imran et al.   Lipids in Health and Disease

Chlorogenic acids and the acyl-quinic acids: discovery, biosynthesis, bioavailability and bioactivity

(2017) Michael N. Clifford et al.   NATURAL PRODUCT REPORTS

Chlorogenic acids, caffeine content and antioxidant properties of green coffee extracts: influence of green coffee bean preparation

(2016) Magdalena Jeszka-Skowron et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Quantitation by HPLC-UV of Mangiferin and Isomangiferin in Coffee (Coffea arabica) Leaves from Brazil and Costa Rica After Solvent Extraction and Infusion

(2016) Maria T. S. Trevisan et al.   Food Analytical Methods

Anti-Angiogenic Properties of Cafestol and Kahweol Palmitate Diterpene Esters

(2016) Marzieh Moeenfard et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Neuroprotective and Antiapoptotic Potential of Trigonelline in a Striatal 6-Hydroxydopamine Rat Model of Parkinson’s Disease

(2016) M. Mirzaie et al.   NEUROPHYSIOLOGY

Chlorogenic acid enhances the effects of 5-fluorouracil in human hepatocellular carcinoma cells through the inhibition of extracellular signal-regulated kinases

(2015) Yuan Yan et al.   ANTI-CANCER DRUGS

Simultaneous Determination of Alkaloids in Green Coffee Beans from Ethiopia: Chemometric Evaluation of Geographical Origin

(2015) Bewketu Mehari et al.   Food Analytical Methods

Dietary Polyphenols in Prevention and Treatment of Prostate Cancer

(2015) Rahul Lall et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduces hyperglycemia and obesity in db/db mice

(2015) Jun Han et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Significance of filamin A in mTORC2 function in glioblastoma

(2015) Naphat Chantaravisoot et al.   Molecular Cancer

Xanthone dimers: a compound family which is both common and privileged

(2015) Tim Wezeman et al.   NATURAL PRODUCT REPORTS

Dietary Polyphenols for Treatment of Alzheimer’s Disease– Future Research and Development

(2014) D. Malar et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways

(2014) Jin-Ju Jeong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Quantification of caffeine, trigonelline and nicotinic acid in espresso coffee: the influence of espresso machines and coffee cultivars

(2014) Giovanni Caprioli et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

5-Caffeoylquinic acid decreases diet-induced obesity in rats by modulating PPARα and LXRα transcription

(2014) Kang Huang et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Correction: Mangiferin Attenuates Diabetic Nephropathy by Inhibiting Oxidative Stress Mediated Signaling Cascade, TNFα Related and Mitochondrial Dependent Apoptotic Pathways in Streptozotocin-Induced Diabetic Rats

(2014)   PLoS One

Ethnomedicinal plants used to treat human ailments in the prehistoric place of Harla and Dengego valleys, eastern Ethiopia

(2014) Anteneh Belayneh et al.   Journal of Ethnobiology and Ethnomedicine

Plant terpenes: defense responses, phylogenetic analysis, regulation and clinical applications

(2014) Bharat Singh et al.   3 Biotech

Mangiferin attenuates MPTP induced dopaminergic neurodegeneration and improves motor impairment, redox balance and Bcl-2/Bax expression in experimental Parkinson’s disease mice

(2013) Mani Kavitha et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Roasting process affects differently the bioactive compounds and the antioxidant activity of arabica and robusta coffees

(2013) Josiane Alessandra Vignoli et al.   FOOD RESEARCH INTERNATIONAL

Identification of Chemical Clusters Discriminators of Arabica and Robusta Green Coffee

(2013) Natalina Cavaco Bicho et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

Caffeine Effects on Sleep Taken 0, 3, or 6 Hours before Going to Bed

(2013) Christopher Drake et al.   Journal of Clinical Sleep Medicine

Caffeine in tea Camellia sinensis — Content, absorption, benefits and risks of consumption

(2013) A. Gramza-Michałowska   Journal of Nutrition Health & Aging

The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction

(2013) Liang-Yu Chen et al.   MOLECULES

2-O-β-d-Glucopyranosyl-carboxyatractyligenin from Coffea L. inhibits adenine nucleotide translocase in isolated mitochondria but is quantitatively degraded during coffee roasting

(2013) Roman Lang et al.   PHYTOCHEMISTRY

A survey of mangiferin and hydroxycinnamic acid ester accumulation in coffee (Coffea) leaves: biological implications and uses

(2012) Claudine Campa et al.   ANNALS OF BOTANY

A cross-over study of the acute effects of espresso coffee on glucose tolerance and insulin sensitivity in people with type 2 diabetes mellitus

(2012) Jeremy D. Krebs et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation

(2011) Min Jung Choi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Experimental diabetes treated with trigonelline: effect on β cell and pancreatic oxidative parameters

(2011) Jiyin Zhou et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice

(2010) Ae-Sim Cho et al.   FOOD AND CHEMICAL TOXICOLOGY

Coffea arabica extract and its constituents prevent photoaging by suppressing MMPs expression and MAP kinase pathway

(2010) Hsiu-Mei Chiang et al.   FOOD AND CHEMICAL TOXICOLOGY

Total phenol concentrations in coffee tree leaves during fruit development

(2010) Paula Rodrigues Salgado et al.   SCIENTIA AGRICOLA

The coffee diterpene kahweol induces apoptosis in human leukemia U937 cells through down-regulation of Akt phosphorylation and activation of JNK

(2009) Jung Hwa Oh et al.   APOPTOSIS

High-Dosage Pyridoxine-Induced Auditory Neuropathy and Protection with Coffee in Mice

(2009) Bin Na Hong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Evaluation of Kahweol and Cafestol in Coffee Tissues and Roasted Coffee by a New High-Performance Liquid Chromatography Methodology

(2009) Rafael Carlos Eloy Dias et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Induced resistance to pests and pathogens in trees

(2009) Alieta Eyles et al.   NEW PHYTOLOGIST

Kahweol blocks STAT3 phosphorylation and induces apoptosis in human lung adenocarcinoma A549 cells

(2009) Hyung Gyun Kim et al.   TOXICOLOGY LETTERS

Caffeine induces Ca2+release by reducing the threshold for luminal Ca2+activation of the ryanodine receptor

(2008) Huihui Kong et al.   BIOCHEMICAL JOURNAL

Caffeine and related purine alkaloids: Biosynthesis, catabolism, function and genetic engineering

(2007) Hiroshi Ashihara et al.   PHYTOCHEMISTRY

Phosphodiesterase inhibitors

(2006) Victoria Boswell-Smith et al.   BRITISH JOURNAL OF PHARMACOLOGY