Journal
REDOX BIOLOGY
Volume 16, Issue -, Pages 352-358Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.redox.2018.03.013
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Funding
- Project for Cancer Research And Therapeutic Evolution (P-CREATE) from AMED [16 cm0106202h0001]
- Center of Innovation Stream from JST
- National Science Fund of Bulgaria [DN11/2]
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This review is directed to the redox-modulating properties and anticancer effect of vitamin K. The concept is focused on two aspects: (i) redox-cycle of vitamin K and its effect on the calcium homeostasis, oncogenic and onco-suppressive reactive oxygen species and the specific induction of oxidative stress in cancer; (ii) vitamin K plus C as a powerful redox-system, which forms a bypass between mitochondrial complexes II and III and thus prevents mitochondrial dysfunction, restores oxidative phosphorylation and aerobic glycolysis, modulates the redox-state of endogenous redox-pairs, eliminates the hypoxic environment of cancer cells and induces cell death. The analyzed data suggest that vitamin C&K can sensitize cancer cells to conventional chemotherapy, which allows achievement of a lower effective dose of the drug and minimizing the harmful side-effects. The review is intended for a wide audience of readers - from students to specialists in the field.
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