Journal
GENETICS AND MOLECULAR RESEARCH
Volume 10, Issue 4, Pages 3236-3245Publisher
FUNPEC-EDITORA
DOI: 10.4238/2011.December.22.1
Keywords
Drosophila melanogaster; Naphthoquinone; Lapachol; Doxorubicin; wts
Funding
- CAPES/CNPq/UFU
Ask authors/readers for more resources
The search for new and effective antitumor agents with fewer cytotoxic side effects on normal tissue has increasingly become important. Lapachol, a natural organic compound isolated from the lapacho tree (Tabebuia avellandedae), is chemically identified as belonging to the naphthoquinone group and is known for its anti-inflammatory, analgesic and antibiotic properties, although there are questions about its effectiveness for treating neoplasic cells. We evaluated the antitumoral effects of lapachol by testing for clones of epithelial tumors in Drosophila melanogaster. Seventy-two-hour old larvae bred from wts/TM3, Sb-1 females and mwh/mwh males, were treated with different concentrations of lapachol (20, 40 and 60 mu g/mL). Lapachol alone did not significantly increase the number of epithelial tumors. However, lapachol did significantly reduce the number of tumors provoked by doxorubicin.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available