Metformin Corrects Glucose Metabolism Reprogramming and NLRP3 Inflammasome-Induced Pyroptosis via Inhibiting the TLR4/NF-κB/PFKFB3 Signaling in Trophoblasts: Implication for a Potential Therapy of Preeclampsia

TLR4-Associated IRF-7 and NFκB Signaling Act as a Molecular Link Between Androgen and Metformin Activities and Cytokine Synthesis in the PCOS Endometrium

(2021) Min Hu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop

(2021) Yang Zhou et al.   World Journal of Diabetes

PFKFB3 regulates lipopolysaccharide-induced excessive inflammation and cellular dysfunction in HTR-8/Svneo cells: Implications for the role of PFKFB3 in preeclampsia

(2021) Yang Zhang et al.   PLACENTA

Placental Mitochondrial Abnormalities in Preeclampsia

(2021) Philippe Vangrieken et al.   Reproductive Sciences

Metformin prevents PFKFB3‑related aerobic glycolysis from enhancing collagen synthesis in lung fibroblasts by regulating AMPK/mTOR pathway

(2021) Ci-Jun Tang et al.   Experimental and Therapeutic Medicine

Impact of metformin treatment during pregnancy on maternal outcomes: a systematic review/meta-analysis

(2021) Jane L. Tarry-Adkins et al.   Scientific Reports

Metformin Attenuates Ischemia-reperfusion Injury of Fatty Liver in Rats Through Inhibition of the TLR4/NF-κB Axis

(2021) Xiaohua Li et al.   Balkan Medical Journal

Pigment epithelium‑derived factor facilitates NLRP3 inflammasome activation through downregulating cytidine monophosphate kinase 2: A potential treatment strategy for missed abortion

(2020) Xi Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Comparative analysis of the mitochondrial morphology, energy metabolism, and gene expression signatures in three types of blastocyst-derived stem cells

(2020) Joonhyuk Choi et al.   Redox Biology

Role of the NLRP3 Inflammasome in Preeclampsia

(2020) Koumei Shirasuna et al.   Frontiers in Endocrinology

Gastrodin improves preeclampsia‐induced cell apoptosis by regulation of TLR4/NF‐κB in rats

(2020) Zhixiong Mei et al.   Food Science & Nutrition

Metabolomics of a mouse model of preeclampsia induced by overexpressing soluble fms-like tyrosine kinase 1

(2020) Emiko Sato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Metformin activates AMPK/SIRT1/NF-κB pathway and induces mitochondrial dysfunction to drive caspase3/GSDME-mediated cancer cell pyroptosis

(2020) Zhaodi Zheng et al.   CELL CYCLE

Quantitative assessment of morphology and sub-cellular changes in macrophages and trophoblasts during inflammation

(2020) RAJWINDER SINGH et al.   Biomedical Optics Express

Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway

(2020) Yifan Jia et al.   Redox Biology

Metformin and Its Benefits for Various Diseases

(2020) Ziquan Lv et al.   Frontiers in Endocrinology

SIRT1 Alleviates LPS-Induced IL-1β Production by Suppressing NLRP3 Inflammasome Activation and ROS Production in Trophoblasts

(2020) Sumi Park et al.   Cells

The NLRP3 Inflammasome Role in the Pathogenesis of Pregnancy Induced Hypertension and Preeclampsia

(2020) Maciej W. Socha et al.   Cells

Preeclampsia—Pathophysiology and Clinical Presentations

(2020) Christopher W. Ives et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Apocynin inhibits placental TLR4/NF-κB signaling pathway and ameliorates preeclampsia-like symptoms in rats

(2020) Han Sha et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Metformin protects against myocardial ischemia-reperfusion injury and cell pyroptosis via AMPK/NLRP3 inflammasome pathway

(2020) Jing Zhang et al.   Aging-US

Regulation of trophoblast cell invasion by Pyruvate Kinase isozyme M2 (PKM2)

(2020) Kary Y.F. Tsai et al.   PLACENTA

Current Researches, Rationale, Plausibility, and Evidence Gaps on Metformin for the Management of Hypertensive Disorders of Pregnancy

(2020) Yang Zhang et al.   Frontiers in Pharmacology

Placental energy metabolism in health and disease—significance of development and implications for preeclampsia

(2020) Irving L.M.H. Aye et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Direct toxicity of insulin on the human placenta and protection by metformin

(2019) Mario Vega et al.   FERTILITY AND STERILITY

NF-κB as the mediator of metformin's effect on ageing and ageing-related diseases

(2019) Gönül Kanigur Sultuybek et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The synergistic effect of PFK15 with metformin exerts anti-myeloma activity via PFKFB3

(2019) Xinling Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protective effect of metformin on a rat model of lipopolysaccharide‐induced preeclampsia

(2019) Jilin Hu et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Ablation of endothelial Pfkfb3 protects mice from acute lung injury in LPS-induced endotoxemia

(2019) Lina Wang et al.   PHARMACOLOGICAL RESEARCH

Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia

(2019) Hong Wa Yung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JASPAR 2020: update of the open-access database of transcription factor binding profiles

(2019) Oriol Fornes et al.   NUCLEIC ACIDS RESEARCH

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

(2019) Yu Wang et al.   Cell Reports

Metformin attenuates hepatoma cell proliferation by decreasing glycolytic flux through the HIF-1α/PFKFB3/PFK1 pathway

(2019) La Hu et al.   LIFE SCIENCES

LPS enhances platelets aggregation via TLR4, which is related to mitochondria damage caused by intracellular ROS, but not extracellular ROS

(2018) Guo Feng et al.   CELLULAR IMMUNOLOGY

Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts

(2018) G. S. Stødle et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

How safe is metformin when initiated in early pregnancy? A retrospective 5-year study of pregnant women with gestational diabetes mellitus from India

(2018) Vanlalhruaii et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Involvement of mTOR, JNK and PI3K in the negative effect of ethanol and metformin on the human first-trimester extravillous trophoblast HTR-8/SVneo cell line

(2018) Ana Correia-Branco et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Soluble Fms-Like Tyrosine Kinase-1 Alters Cellular Metabolism and Mitochondrial Bioenergetics in Preeclampsia

(2018) Lissette C. Sánchez-Aranguren et al.   Frontiers in Physiology

Metformin inhibited colitis and colitis-associated cancer (CAC) through protecting mitochondrial structures of colorectal epithelial cells in mice

(2018) Shu-Qing Wang et al.   CANCER BIOLOGY & THERAPY

Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome

(2018) Xiaofei Peng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Metabolic regulation of NLRP3

(2017) Mark M. Hughes et al.   IMMUNOLOGICAL REVIEWS

Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts

(2017) Kazuhiro Tamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis

(2017) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates inflammasome-induced pyroptosis through inhibiting NF-κB/GSDMD signal in mice adipose tissue

(2017) Zhenjiang Liu et al.   JOURNAL OF PINEAL RESEARCH

Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia

(2017) Ingrid C.Weel et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Oxygen and placental development; parallels and differences with tumour biology

(2017) Graham J. Burton et al.   PLACENTA

Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3

(2016) Jian Fu   CELLULAR SIGNALLING

Metabolomic determination of pathogenesis of late-onset preeclampsia

(2016) Ray O. Bahado-Singh et al.   Journal of Maternal-Fetal & Neonatal Medicine

Metformin versus Placebo in Obese Pregnant Women without Diabetes Mellitus

(2016) Argyro Syngelaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

(2016) Min Xie et al.   Nature Communications

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2E3 Ligase

(2015) SeungHye Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation

(2015) Jong-Seok Moon et al.   Cell Reports

Single Administration of Ultra-Low-Dose Lipopolysaccharide in Rat Early Pregnancy Induces TLR4 Activation in the Placenta Contributing to Preeclampsia

(2015) Pingping Xue et al.   PLoS One

Glucose and Metformin Modulate Human First Trimester Trophoblast Function: a Model and Potential Therapy for Diabetes-Associated Uteroplacental Insufficiency

(2014) Christina S. Han et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

(2014) Takehiro Yamamoto et al.   Nature Communications

Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome

(2013) T. Fernandes-Alnemri et al.   JOURNAL OF IMMUNOLOGY

A leading role for the immune system in the pathophysiology of preeclampsia

(2013) Estibalitz Laresgoiti-Servitje   JOURNAL OF LEUKOCYTE BIOLOGY

Non-transcriptional Priming and Deubiquitination Regulate NLRP3 Inflammasome Activation

(2012) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolomics and first-trimester prediction of early-onset preeclampsia

(2012) Ray O. Bahado-Singh et al.   Journal of Maternal-Fetal & Neonatal Medicine

MIR-210 modulates mitochondrial respiration in placenta with preeclampsia

(2012) S. Muralimanoharan et al.   PLACENTA

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta

(2010) S. Haché et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer

(2009) Abdullah Yalcin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY