Review
Cell Biology
Zi-Yi Zhou, Lin Wang, Yu-Sheng Wang, Guo-Rui Dou
Summary: The current treatment for ocular pathological angiogenesis focuses on anti-VEGF signals, but regulation of endothelial glycolysis has emerged as a potential treatment targeting vessel sprouting.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Shengchen Lin, Yunzhan Li, Dezhen Wang, Chongbiao Huang, David Marino, Oana Bollt, Chaodong Wu, Matthew D. Taylor, Wei Li, Gina M. DeNicola, Jihui Hao, Pankaj K. Singh, Shengyu Yang
Summary: Fascin, a pro-metastatic actin-bundling protein, promotes cancer cell migration and invasion by increasing glycolysis in lung cancer through activation of yes-associated protein 1 (YAP1). The fascin-YAP1-PFKFB3 axis is likely conserved across different types of cancers, and pharmacological inhibitors of fascin may be used to reprogram cancer metabolism in lung and potentially other cancers with fascin upregulation.
Article
Medicine, General & Internal
Yanyan Song, Song Chen, Wei Xiang, Muran Xiao, Hui Xiao
Summary: Patients with type 2 diabetes have a higher risk of malignancy, but treatment with metformin can reduce this risk. The study showed that metformin can enhance the sensitivity of multiple myeloma cells to melphalan by promoting DNA damage and decreasing ATP concentration to hinder the anti-apoptotic process.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Letter
Oncology
Seiichi Okabe, Yuko Tanaka, Akihiko Gotoh
Summary: The treatment of multiple myeloma has been improved with the introduction of new drugs, but relapse is still common. Hypoxia plays a crucial role in the bone marrow microenvironment. Inhibitors of PFKFB3 and PFKFB4 show potential in inhibiting myeloma cell growth and enhancing cytotoxicity. Combination treatment with proteasome inhibitors and PFKFB inhibitors has shown enhanced cytotoxic effects.
BIOMARKER RESEARCH
(2022)
Article
Oncology
Lingzhi Wang, Yanling Lin, Xiaohan Zhou, Yuting Chen, Xueying Li, Wenxiao Luo, Yingtong Zhou, Longmei Cai
Summary: CYLD inhibits glycolysis in nasopharyngeal carcinoma by regulating p53 and FZR1, delaying tumor growth and progression, and serving as a biomarker for poor prognosis.
Article
Oncology
Arne Van der Vreken, Inge Oudaert, Gamze Ates, Sylvia Faict, Philip Vlummens, Hatice Satilmis, Rong Fan, Anke Maes, Ann Massie, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Eline Menu
Summary: This study suggests an alternative combination treatment for multiple myeloma by targeting metabolic pathways. The combination of syrosingopine and metformin shows strong cytotoxic effects on multiple myeloma cell lines and patient samples, suppressing both glycolysis and oxidative phosphorylation. Furthermore, the combination treatment leads to a significant reduction in tumor burden in vivo.
JOURNAL OF PATHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Beth A. Griesel, Satoshi Matsuzaki, Albert Batushansky, Timothy M. Griffin, Kenneth M. Humphries, Ann Louise Olson
Summary: This study using 3T3-L1 adipocytes as a model system found that an increase in glucose uptake during the first 3 days of differentiation promoted the expansion of the adipocyte metabolome and proteome. The positive effects were specifically due to increased expression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), highlighting its critical role in regulating cellular metabolic remodeling for adipocyte differentiation and maturation.
Review
Chemistry, Medicinal
Izabela Szymczak-Pajor, Sylwia Wenclewska, Agnieszka Sliwinska
Summary: Metformin, a first-line drug for T2DM treatment, influences metabolism through various mechanisms. It suppresses hepatic glucose production and intestinal lipid secretion, while enhancing fatty acid oxidation in adipose tissue and muscles. Additionally, metformin improves systemic insulin sensitivity by altering gut microbiota composition, maintaining intestinal barrier integrity, and alleviating low-grade inflammation.
Article
Multidisciplinary Sciences
Irene Lopez-Fabuel, Marina Garcia-Macia, Costantina Buondelmonte, Olga Burmistrova, Nicolo Bonora, Paula Alonso-Batan, Brenda Morant-Ferrando, Carlos Vicente-Gutierrez, Daniel Jimenez-Blasco, Ruben Quintana-Cabrera, Emilio Fernandez, Jordi Llop, Pedro Ramos-Cabrer, Aseel Sharaireh, Marta Guevara-Ferrer, Lorna Fitzpatrick, Christopher D. Thompton, Tristan R. McKay, Stephan Storch, Diego L. Medina, Sara E. Mole, Peter O. Fedichev, Angeles Almeida, Juan P. Bolanos
Summary: The study reveals that failure in autophagy leads to the accumulation of impaired neuronal mitochondria in a CLN7 disease mouse model. It also shows that the increased activity of glycolytic enzyme PFKFB3 may contribute to the pathogenesis of CLN7 and that its inhibition can alleviate disease hallmarks.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Chengcheng Song, Shuqiang Wang, Zhangning Fu, Kun Chi, Xiaodong Geng, Chao Liu, Guangyan Cai, Xiangmei Chen, Di Wu, Quan Hong
Summary: Renal inflammation is a critical characteristic of diabetic kidney disease (DKD), but effective treatments are limited. This study found that insulin-like growth factor-binding protein 5 (IGFBP5) is significantly increased in the kidneys of diabetic mice. Elimination of IGFBP5 alleviated kidney inflammation in DKD mice. Mechanistically, IGFBP5 increased glycolysis in endothelial cells through the activation of the transcription factor EGR1 and enhanced expression of PFKFB3, which in turn enhanced renal inflammation.
CELL DEATH & DISEASE
(2022)
Article
Biology
Antonius Christianto, Takashi Baba, Fumiya Takahashi, Kai Inui, Miki Inoue, Mikita Suyama, Yusuke Ono, Yasuyuki Ohkawa, Ken-ichirou Morohashi
Summary: Baba et al. analyzed the transcriptomes of quadriceps type IIB fibers in male and female mice, identifying Pfkfb3 and Pdk4 as differentially regulated genes and potential switches between sexually dimorphic metabolic pathways. The study demonstrates male-enriched and estradiol-enhanced expression of Pfkfb3 and Pdk4, shedding light on energy metabolism differences between the sexes.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ulli Heydasch, Renate Kessler, Jan-Peter Warnke, Klaus Eschrich, Nicole Scholz, Marina Bigl
Summary: The study highlights the significance of PFKFB3 in cancer, particularly in glioblastoma. Experimental findings suggest that different splice variants of PFKFB3 may have distinct effects, altering cell behavior and tumor growth, providing valuable insights for the treatment and diagnosis of glioblastoma.
Article
Oncology
Xinling Liu, Jiaqiu Li, Zhanju Wang, Jie Meng, Aihong Wang, Xiaofei Zhao, Qilu Xu, Zhen Cai, Zhenbo Hu
Summary: The lysine demethylase KDM2A plays a crucial role in multiple myeloma by regulating key biological processes such as cell proliferation, glycolysis, and angiogenesis through its ubiquitin ligase activity. Patients with low KDM2A and high PFKFB3 levels have a worse prognosis, indicating KDM2A as a potential therapeutic target for MM treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hao Zeng, Ting Pan, Meiling Zhan, Renaguli Hailiwu, Baolin Liu, Hua Yang, Ping Li
Summary: Endothelial cells can undergo endothelial-to-mesenchymal transition (EndoMT) in cardiac fibrosis, and this process is driven by abnormal glycolysis mediated by 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3). Pharmacological intervention of PFKFB3 with salvianolic acid C (SAC) can attenuate EndoMT and fibrotic response.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Haiyan He, Mengting Liu, Rong He, Wei Zhao
Summary: This study extracted soluble soybean polysaccharides from soybean dregs and used them as a carrier material to prepare metformin-soluble soybean polysaccharide nanoparticles. The nanoparticles were found to lower cholesterol levels and affect the expression of related proteins. Animal experiments also confirmed the lipid-lowering effect of these nanoparticles. Therefore, they have potential applications in lipid lowering.
Article
Oncology
Xingying Li, Hui Yu, Xiaorui Fu, Lei Zhang, Xin Li, Ling Li, Xinhua Wang, Zhenchang Sun, Xudong Zhang, Zhaoming Li, Jingjing Wu, Yu Chang, Jiaqin Yan, Zhiyuan Zhou, Feifei Nan, Xiaolong Wu, Li Tian, Mingzhi Zhang
Summary: Extranodal natural killer (NK)/T-cell lymphoma (NKTL) rarely involves the central nervous system (CNS) and has a poor prognosis with no standard treatment. In a study of 414 ENKL patients, 4.59% were diagnosed with CNS involvement. 2 patients had primary CNS (PCNS) NKTL and 17 patients had secondary CNS (SCNS) invasion. 9 patients survived with a median overall survival time of 55 months, and the median survival time after CNS invasion was 17 months. The 5-year cumulative survival probability was 45.7%. Evaluation and prophylaxis treatment for CNS risk is recommended for patients with NK/T-cell lymphoma prognostic index risk group III/IV, and systemic therapy based on methotrexate combined with radiotherapy and intrathecal chemotherapy can be considered.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Metallurgy & Metallurgical Engineering
Xiangchen Meng, Yuming Xie, Xiaotian Ma, Mingyang Liang, Xiaoyang Peng, Shiwei Han, Lei Kan, Xin Wang, Sihao Chen, Yongxian Huang
Summary: Volumetric defects in high-strength aluminum alloy components were successfully repaired using friction stir remanufacturing (FSR). The design of consumable pins had a significant impact on material flow, forging at the repairing interface, load transfer, and fracture characteristics. Proper design criteria resulted in sound repaired components with improved tensile strength and elongation.
ACTA METALLURGICA SINICA-ENGLISH LETTERS
(2023)
Article
Endocrinology & Metabolism
Shangling Wu, Pinning Feng, Wanlin Li, Shuyu Zhuo, Wei Lu, Peiyan Chen, Yi Sui, Shi Fang, Zhongyi Yang, Yanbin Ye
Summary: The study suggests that a high intake of folate and vitamin B6, but not vitamin B12, may be associated with a reduced risk of cardiovascular disease (CVD) in patients with type 2 diabetes (T2D). Folate intake from eggs, vegetables, fruits, soy, and other foods was found to be inversely associated with CVD risk, while folate intake from grains showed no significant association.
ANNALS OF NUTRITION AND METABOLISM
(2023)
Article
Entomology
Xiaomei Wang, Ruting Chen, Niya Jia, Jiaxing Sun, Yuxin Luo, Yunzhao Yang, Yutong Zhuang, Jingfeng Wang, Hongru Guo, Defu Chi
Summary: Spraying bacterial or fungal solutions during the flowering stage of Korean pine positively impacted seed quality and effectively decreased damage by lepidopteran species that feed on the cones and seeds in this study.
BULLETIN OF ENTOMOLOGICAL RESEARCH
(2023)
Article
Environmental Sciences
Yan Yang, Li Zhou, Wenling Zhang, Yanjun Yang, Yanyan Liu, Li Pan, Yanbei Huo, Ruijuan Wang, Yupei Ba, Xiaoyu Ren, Yana Bai, Ning Cheng
Summary: This study provides further evidence that exposure to air pollutants in the first trimester of pregnancy significantly increases the risk of neural tube defects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Min Li, Bin Dong, Zhidong Chang, Hui Dang, Sihang Ma, Wenjun Li
Summary: In this study, spent SCR catalyst was used to recover TiO2 and modified with g-C3N4 to prepare the R-TiO2/g-C3N4 photocatalyst. XRD patterns confirmed that R-TiO2 maintained the crystal structure of anatase TiO2. The photodegradation efficiency of R-TiO2/g-C3N4 photocatalyst reached 97.11% for Rhodamine B degradation under visible light, which was 1.9 times higher than that of pure TiO2/g-C3N4 photocatalyst.
WASTE AND BIOMASS VALORIZATION
(2023)
Review
Oncology
Hang Yang, Xinyi Zhou, Dongliang Fu, Chenqin Le, Jiafeng Wang, Quan Zhou, Xiangrui Liu, Ying Yuan, Kefeng Ding, Qian Xiao
Summary: RAS genes are frequently mutated oncogenes that play critical roles in malignancy. Currently, only a small portion of RAS-targeted therapies are effective clinically. Further research on RAS signal transduction, metabolism, and immune microenvironment is needed to develop more effective treatments.
CANCER COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Gui-Yan Shao, Qing-Qing Tian, Wen-Bo Li, Su-Yan Wang, Yu-Xi Lu, Fei Liu, Bo-Xing Cheng
Summary: In this study, the role and expression of Kazal-type serine protease inhibitors in the salivary glands of Poecilobdella manillensis were investigated. The results showed that these proteins inhibit thrombin activity.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Energy & Fuels
Wei Liu, Jing Liu, Yingju Yang, Bo Xiong, Hongcun Bai
Summary: The study investigates the performance of a series of trimetallic TM-NiFe catalysts for electrochemical CO2 reduction reaction. The results demonstrate that different compositions of catalysts exhibit advantages in converting CO2 to different chemical products, providing a reliable foundation for improving catalyst activity and selectivity in CO2 conversion.
Article
Engineering, Mechanical
Xin Bao, Shutao Li, Jingbo Liu, Fei Wang, Yeqing Chen, Longming Chen, Qing Zhu
Summary: This study focuses on the dynamic responses and damage mechanisms of a deep-buried underground structure subjected to explosions. Model tests were conducted and analyzed, revealing that the underground structure experienced minimal damage compared to the surrounding rock model. However, the spectral acceleration on the floor of the prototype structure posed a safety threat to human usage.
INTERNATIONAL JOURNAL OF IMPACT ENGINEERING
(2023)
Article
Computer Science, Artificial Intelligence
Peisong Wang, Fanrong Li, Gang Li, Jian Cheng
Summary: In this article, the advantages of extremely sparse networks with binary connections for image classification through software-hardware codesign are investigated. A binary augmented extremely pruning method is proposed to achieve high sparsity with minimal accuracy degradation, and a hardware architecture based on the resulting sparse and binary networks is designed to explore the benefits of extreme sparsity with negligible consumption. Experiments on ImageNet classification and FPGA demonstrate a significant tradeoff between accuracy and efficiency in the proposed software-hardware architecture.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Computer Science, Artificial Intelligence
Bo Jiang, Leiling Wang, Jian Cheng, Jin Tang, Bin Luo
Summary: Compact representation of graph data is a fundamental problem in pattern recognition and machine learning. Graph neural networks (GNNs) have been widely studied for graph-structured data representation and learning. In this article, a new model called graph propagation-embedding networks (GPENs) is proposed, which integrates feature propagation and low-dimensional embedding into a unified network. GPENs have good motivation and can be well-explained, and they guarantee both compactness and efficiency. Experiments demonstrate the effectiveness and benefits of GPENs and M-GPENs.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Computer Science, Artificial Intelligence
Jiangrong Shen, Yu Zhao, Jian K. Liu, Yueming Wang
Summary: In this article, the authors propose a hybrid deep spiking neural network model called HybridSNN, which utilizes data-driven greedy optimization to build powerful classifiers and avoids derivative problems in gradient descent. HybridSNN combines the advantages of low power consumption and global data-driven optimization, and its flexible network structure is learned from training samples.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Clinical Neurology
Dongling Zhang, Yuting Shi, Junye Yao, Liche Zhou, Hongjiang Wei, Jun Liu, Qiqi Tong, Lingyan Ma, Hongjian He, Tao Wu
Summary: Pathogenic variants in the GBA gene are associated with substantia nigra damage in Parkinson's disease. Elevated free water values in the posterior substantia nigra are observed in GBA pathogenic variant carriers and Parkinson's disease patients, and they predict the development of non-motor symptoms.
MOVEMENT DISORDERS
(2023)
Article
Ecology
Luhua Yang, Renhua Sun, Jungai Li, Limei Zhai, Huiling Cui, Bingqian Fan, Hongyuan Wang, Hongbin Liu
Summary: This study investigated the impact of different soil types, plant varieties, and fertilizer regimens on soil and root bacterial communities. The results showed that combined organic-inorganic fertilization led to higher stability of microbial networks. The variation in root microbiome was mainly influenced by total nitrogen, while the variation in soil microbiome was primarily influenced by pH and soil organic matter.
SOIL ECOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
