Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

(2019) João Moura et al.   Scientific Reports

Effects of metformin and phenformin on apoptosis and epithelial‐mesenchymal transition in chemoresistant rectal cancer

(2019) Ji‐Hye Park et al.   CANCER SCIENCE

Association of Elevated Urinary miR-126, miR-155, and miR-29b with Diabetic Kidney Disease

(2018) Cristina Beltrami et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuroprotective effects of metformin on traumatic brain injury in rats associated with NF-κB and MAPK signaling pathway

(2018) Li Tao et al.   BRAIN RESEARCH BULLETIN

Antitumor effects of metformin are a result of inhibiting nuclear factor kappa B nuclear translocation in esophageal squamous cell carcinoma

(2018) Nobufumi Sekino et al.   CANCER SCIENCE

Prevention of progression of diabetic nephropathy by the SGLT2 inhibitor ipragliflozin in uninephrectomized type 2 diabetic mice

(2018) Atsuo Tahara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MiR-155 targets PTCH1 to mediate endothelial progenitor cell dysfunction caused by high glucose

(2018) Jie Gao et al.   EXPERIMENTAL CELL RESEARCH

Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease

(2018) Yue Wang et al.   Journal of Translational Medicine

Tenascin‑C promotes the migration of bone marrow stem cells via toll‑like receptor 4‑mediated signaling pathways: MAPK, AKT and Wnt

(2018) Huaiyu Ding et al.   Molecular Medicine Reports

Homeobox a5 Promotes White Adipose Tissue Browning Through Inhibition of the Tenascin C/Toll-Like Receptor 4/Nuclear Factor Kappa B Inflammatory Signaling in Mice

(2018) Weina Cao et al.   Frontiers in Immunology

The Potential Role of Platelet-Related microRNAs in the Development of Cardiovascular Events in High-Risk Populations, Including Diabetic Patients: A Review

(2018) Justyna Pordzik et al.   Frontiers in Endocrinology

Endothelial function and dysfunction: Impact of metformin

(2018) Asma Nafisa et al.   PHARMACOLOGY & THERAPEUTICS

Regulation of IL-6 Secretion by Astrocytes via TLR4 in the Fragile X Mouse Model

(2018) Victoria Krasovska et al.   Frontiers in Molecular Neuroscience

Tenascin-C accelerates adverse ventricular remodelling after myocardial infarction by modulating macrophage polarization

(2018) Taizo Kimura et al.   CARDIOVASCULAR RESEARCH

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development

(2018) Claudiane Guay et al.   Cell Metabolism

In silico identification of potential drug compound against Peroxisome proliferator-activated receptor-gamma by virtual screening and toxicity studies for the treatment of Diabetic Nephropathy

(2017) Smrita Singh et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease

(2017) Shashi Bala et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers

(2017) Lorena Zuliani-Alvarez et al.   Nature Communications

Diet-Induced Obesity Enhances Progression of Hepatocellular Carcinoma through Tenascin-C/Toll-Like Receptor 4 Signaling

(2016) Jennifer H. Benbow et al.   AMERICAN JOURNAL OF PATHOLOGY

Diabetic nephropathy: where are we on the journey from pathophysiology to treatment?

(2016) H. Gallagher et al.   DIABETES OBESITY & METABOLISM

Spatiotemporal expression of endogenous TLR4 ligands leads to inflammation and bone erosion in mouse collagen-induced arthritis

(2016) Gaëlle Wambiekele Kiyeko et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: An update

(2016) Niloy Bhattacharjee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis

(2016) Shashi Bala et al.   JOURNAL OF HEPATOLOGY

Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis

(2016) Haiyan Fu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages

(2016) Anna M. Piccinini et al.   Science Signaling

Tenascin-C drives persistence of organ fibrosis

(2016) Swati Bhattacharyya et al.   Nature Communications

miRNAs in Urine Extracellular Vesicles as Predictors of Early-Stage Diabetic Nephropathy

(2016) Yijie Jia et al.   Journal of Diabetes Research

Distinct microenvironmental cues stimulate divergent TLR4-mediated signaling pathways in macrophages

(2016) Anna M. Piccinini et al.   Science Signaling

HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration

(2015) A Aguado et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dicer Cleavage by Calpain Determines Platelet microRNA Levels and Function in DiabetesNovelty and Significance

(2015) Amro Elgheznawy et al.   CIRCULATION RESEARCH

ATF3 Inhibits Tenascin-C-induced Foam Cell Formation in LPS-Stimulated THP-1 Macrophages by Suppressing TLR-4

(2015) Hong Luo et al.   Journal of Atherosclerosis and Thrombosis

Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes

(2015) Gina Manda et al.   MEDIATORS OF INFLAMMATION

Innate immunity in diabetes and diabetic nephropathy

(2015) Jun Wada et al.   Nature Reviews Nephrology

MicroRNA-155 Deficiency Promotes Nephrin Acetylation and Attenuates Renal Damage in Hyperglycemia-Induced Nephropathy

(2014) Xu Lin et al.   INFLAMMATION

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status

(2014) Amandine Everard et al.   Nature Communications

Tenascin‐C Aggravates Autoimmune Myocarditis via Dendritic Cell Activation and Th17 Cell Differentiation

(2014) Tomoko Machino‐Ohtsuka et al.   Journal of the American Heart Association

Tenascin-C induces prolonged constriction of cerebral arteries in rats

(2013) Masashi Fujimoto et al.   NEUROBIOLOGY OF DISEASE

KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update

(2012)   AMERICAN JOURNAL OF KIDNEY DISEASES

Increased Tenascin C And Toll-Like Receptor 4 Levels in Visceral Adipose Tissue as a Link between Inflammation and Extracellular Matrix Remodeling in Obesity

(2012) Victoria Catalán et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Isolated Toll-like Receptor Transmembrane Domains Are Capable of Oligomerization

(2012) James I. Godfroy et al.   PLoS One

Endogenous Control of Immunity against Infection: Tenascin-C Regulates TLR4-Mediated Inflammation via MicroRNA-155

(2012) Anna M. Piccinini et al.   Cell Reports

Tenascins and the Importance of Adhesion Modulation

(2011) R. Chiquet-Ehrismann et al.   Cold Spring Harbor Perspectives in Biology

High circulating levels of large splice variants of tenascin-C is associated with mortality and cardiovascular disease in chronic kidney disease patients

(2010) Sophie Liabeuf et al.   ATHEROSCLEROSIS

Up-regulation of MicroRNA-155 in Macrophages Contributes to Increased Tumor Necrosis Factor α (TNFα) Production via Increased mRNA Half-life in Alcoholic Liver Disease

(2010) Shashi Bala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Regulation of the Endogenous Danger Signal Tenascin-C: A Novel Autocrine Loop in Inflammation

(2010) Fui G. Goh et al.   JOURNAL OF IMMUNOLOGY

Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice

(2010) Toru Hosoi et al.   PLoS One

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

MicroRNAs: Novel Regulators During the Immune Response

(2008) Yujing Bi et al.   JOURNAL OF CELLULAR PHYSIOLOGY