Lessons from Injury: How Nerve Injury Studies Reveal Basic Biological Mechanisms and Therapeutic Opportunities for Peripheral Nerve Diseases

The prion protein is not required for peripheral nerve de- and remyelination after crush injury

(2021) Anna Henzi et al.   PLoS One

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

(2021) Laura J Wagstaff et al.   eLife

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

(2021) Matthew D. Figley et al.   NEURON

Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy

(2021) Todd Bosanac et al.   BRAIN

Protection against oxaliplatin-induced mechanical and thermal hypersensitivity in Sarm1−/− mice

(2021) Stacey Anne Gould et al.   EXPERIMENTAL NEUROLOGY

H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve

(2021) Phu Duong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nerve guide conduits for peripheral nerve injury repair: A review on design, materials and fabrication methods

(2020) Sanjairaj Vijayavenkataraman   Acta Biomaterialia

DNA methylation in Schwann cells and in oligodendrocytes

(2020) Peter Arthur‐Farraj et al.   GLIA

Cytotoxic Immunity in Peripheral Nerve Injury and Pain

(2020) Alexander J. Davies et al.   Frontiers in Neuroscience

Programmed axon degeneration: from mouse to mechanism to medicine

(2020) Michael P. Coleman et al.   NATURE REVIEWS NEUROSCIENCE

Axon-dependent expression of YAP/TAZ mediates Schwann cell remyelination but not proliferation after nerve injury

(2020) Matthew Grove et al.   eLife

Characterising cellular and molecular features of human peripheral nerve degeneration

(2020) Matthew B. Wilcox et al.   Acta Neuropathologica Communications

Axo‐glial interaction in the injured PNS

(2020) Ruth M. Stassart et al.   Developmental Neurobiology

Assessing non-Mendelian inheritance in inherited axonopathies

(2020) Dana M. Bis-Brewer et al.   GENETICS IN MEDICINE

Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge

(2020) Qing Min et al.   GLIA

Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury

(2020) Chelsey B. Reed et al.   JOURNAL OF NEUROSCIENCE

EEF1A1 deacetylation enables transcriptional activation of remyelination

(2020) Mert Duman et al.   Nature Communications

The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1

(2020) Yuefeng Jiang et al.   NATURE

A glycolytic shift in Schwann cells supports injured axons

(2020) Elisabetta Babetto et al.   NATURE NEUROSCIENCE

CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair

(2020) Jincheng Wang et al.   Nature Communications

Satellite glial cells promote regenerative growth in sensory neurons

(2020) Oshri Avraham et al.   Nature Communications

YAP and TAZ regulate Schwann cell proliferation and differentiation during peripheral nerve regeneration

(2020) Haley Jeanette et al.   GLIA

Cisplatin induced neurotoxicity is mediated by Sarm1 and calpain activation

(2020) Aysel Cetinkaya-Fisgin et al.   Scientific Reports

Direct conversion of adult human skin fibroblasts into functional Schwann cells that achieve robust recovery of the severed peripheral nerve in rats

(2019) Masaaki Kitada et al.   GLIA

Repair Schwann cell update: Adaptive reprogramming, EMT, and stemness in regenerating nerves

(2019) Kristjan R Jessen et al.   GLIA

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

(2019) Joseph R. Klim et al.   NATURE NEUROSCIENCE

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

(2019) Ze’ev Melamed et al.   NATURE NEUROSCIENCE

A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome

(2019) Akira Wiberg et al.   Nature Communications

The Success and Failure of the Schwann Cell Response to Nerve Injury

(2019) Kristjan R. Jessen et al.   Frontiers in Cellular Neuroscience

Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence

(2019) Marshall Lukacs et al.   EXPERIMENTAL NEUROLOGY

Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia

(2019) Peter Huppke et al.   EXPERIMENTAL NEUROLOGY

Time-restricted release of multiple neurotrophic factors promotes axonal regeneration and functional recovery after peripheral nerve injury

(2019) Liangliang Huang et al.   FASEB JOURNAL

Schwann cell plasticity-roles in tissue homeostasis, regeneration, and disease

(2019) Salome Stierli et al.   GLIA

RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation

(2019) Jorge Galino et al.   JOURNAL OF CELL BIOLOGY

NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies

(2019) Robert Fledrich et al.   Nature Communications

Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration

(2019) Adrien Vaquié et al.   Cell Reports

Role of Long Noncoding RNAs and Circular RNAs in Nerve Regeneration

(2019) Chun Yao et al.   Frontiers in Molecular Neuroscience

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration

(2019) Daniel W. Summers et al.   MOLECULAR NEUROBIOLOGY

Gpr126/Adgrg6 contributes to the terminal Schwann cell response at the neuromuscular junction following peripheral nerve injury

(2019) Albina Jablonka‐Shariff et al.   GLIA

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

(2019) Andrea Loreto et al.   NEUROBIOLOGY OF DISEASE

Integrins promote axonal regeneration after injury of the nervous system

(2018) Bart Nieuwenhuis et al.   BIOLOGICAL REVIEWS

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis

(2018) Owen M Peters et al.   HUMAN MOLECULAR GENETICS

Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells

(2018) Clara Gomis-Coloma et al.   JOURNAL OF CELL BIOLOGY

Sustained Expression of Negative Regulators of Myelination Protects Schwann Cells from Dysmyelination in a Charcot–Marie–Tooth 1B Mouse Model

(2018) Francesca Florio et al.   JOURNAL OF NEUROSCIENCE

mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation

(2018) Camilla Norrmén et al.   JOURNAL OF NEUROSCIENCE

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

(2018) Kuan-Chuan Pao et al.   NATURE

A histone deacetylase 3–dependent pathway delimits peripheral myelin growth and functional regeneration

(2018) Xuelian He et al.   NATURE MEDICINE

Intrinsic mechanisms of neuronal axon regeneration

(2018) Marcus Mahar et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetic Control of Schwann Cells

(2018) Ki H. Ma et al.   NEUROSCIENTIST

Schwann cell O-GlcNAcylation promotes peripheral nerve remyelination via attenuation of the AP-1 transcription factor JUN

(2018) Sungsu Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Palmitoylation enables MAPK-dependent proteostasis of axon survival factors

(2018) Daniel W. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration

(2018) Ruben Eggers et al.   BRAIN

The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population

(2018) Salome Stierli et al.   DEVELOPMENT

Polycomb repression regulates Schwann cell proliferation and axon regeneration after nerve injury

(2018) Ki H. Ma et al.   GLIA

Low levels of NMNAT2 compromise axon development and survival

(2018) Jonathan Gilley et al.   HUMAN MOLECULAR GENETICS

Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury

(2018) Zhengxin Ying et al.   MOLECULAR CELL

KIAA1199: A novel regulator of MEK/ERK-induced Schwann cell dedifferentiation

(2017) Angélique Boerboom et al.   GLIA

Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity

(2017) Thomas Mindos et al.   JOURNAL OF CELL BIOLOGY

The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair

(2017) Sheridan L. Roberts et al.   JOURNAL OF NEUROCHEMISTRY

After Nerve Injury, Lineage Tracing Shows That Myelin and Remak Schwann Cells Elongate Extensively and Branch to Form Repair Schwann Cells, Which Shorten Radically on Remyelination

(2017) Jose A. Gomez-Sanchez et al.   JOURNAL OF NEUROSCIENCE

Postinjury Induction of Activated ErbB2 Selectively Hyperactivates Denervated Schwann Cells and Promotes Robust Dorsal Root Axon Regeneration

(2017) Seung Baek Han et al.   JOURNAL OF NEUROSCIENCE

Sustained MAPK/ERK Activation in Adult Schwann Cells Impairs Nerve Repair

(2017) Ilaria Cervellini et al.   JOURNAL OF NEUROSCIENCE

STAT3 Controls the Long-Term Survival and Phenotype of Repair Schwann Cells during Nerve Regeneration

(2017) Cristina Benito et al.   JOURNAL OF NEUROSCIENCE

Graded Elevation of c-Jun in Schwann CellsIn Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination

(2017) Shaline V. Fazal et al.   JOURNAL OF NEUROSCIENCE

Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy

(2017) Elliot Turkiew et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly

(2017) Lukas J. Neukomm et al.   NEURON

The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration

(2017) Melanie P. Clements et al.   NEURON

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

First human experience with autologous Schwann cells to supplement sciatic nerve repair: report of 2 cases with long-term follow-up

(2017) Zachary C. Gersey et al.   Neurosurgical Focus

Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury

(2017) Amanda Brosius Lutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular analysis of axonal-intrinsic and glial-associated co-regulation of axon degeneration

(2017) Alejandra Catenaccio et al.   Cell Death & Disease

Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration

(2017) Valérie Brügger et al.   Nature Communications

Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells

(2017) Pietro Giuseppe Mazzara et al.   Nature Communications

Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury

(2017) Peter J. Arthur-Farraj et al.   Cell Reports

Sarm1 Deletion, but Not Wld S , Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy

(2017) Jonathan Gilley et al.   Cell Reports

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

(2017) Lauren J Walker et al.   eLife

Methylation-based classification of benign and malignant peripheral nerve sheath tumors

(2016) Manuel Röhrich et al.   ACTA NEUROPATHOLOGICA

TBCE Mutations Cause Early-Onset Progressive Encephalopathy with Distal Spinal Muscular Atrophy

(2016) Antonella Sferra et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice

(2016) Stefanie Geisler et al.   BRAIN

The multicellular complexity of peripheral nerve regeneration

(2016) Anne-Laure Cattin et al.   CURRENT OPINION IN NEUROBIOLOGY

Loss of Schwann cell plasticity in chronic inflammatory demyelinating polyneuropathy (CIDP)

(2016) Abhijeet R. Joshi et al.   Journal of Neuroinflammation

Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury

(2016) K. H. Ma et al.   JOURNAL OF NEUROSCIENCE

Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair

(2016) Amit Mogha et al.   JOURNAL OF NEUROSCIENCE

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

(2016) Wouter van Rheenen et al.   NATURE GENETICS

Zeb2 recruits HDAC–NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination

(2016) Lai Man Natalie Wu et al.   NATURE NEUROSCIENCE

Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair

(2016) Susanne Quintes et al.   NATURE NEUROSCIENCE

An Atypical SCF-like Ubiquitin Ligase Complex Promotes Wallerian Degeneration through Regulation of Axonal Nmnat2

(2016) Yuya Yamagishi et al.   Cell Reports

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

(2016) Yousuf O. Ali et al.   PLOS BIOLOGY

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

(2016) Yo Sasaki et al.   eLife

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

(2016) Samuel A.J. Trammell et al.   Scientific Reports

Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury

(2015) Peiwen Chen et al.   ACTA NEUROPATHOLOGICA

The Role of Cell Plasticity in Tissue Repair: Adaptive Cellular Reprogramming

(2015) Kristjan R. Jessen et al.   DEVELOPMENTAL CELL

Clinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesion

(2015) Ruben Eggers et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen

(2015) Jose A. Martinez et al.   EXPERIMENTAL NEUROLOGY

Autophagic myelin destruction by schwann cells during wallerian degeneration and segmental demyelination

(2015) So Young Jang et al.   GLIA

Microprocessor Complex Subunit DiGeorge Syndrome Critical Region Gene 8 (Dgcr8) Is Required for Schwann Cell Myelination and Myelin Maintenance

(2015) Hsin-Pin Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Regulation of Schwann Cell Enhancers after Peripheral Nerve Injury

(2015) Holly A. Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

(2015) Jose A. Gomez-Sanchez et al.   JOURNAL OF CELL BIOLOGY

The lh3 Glycosyltransferase Directs Target-Selective Peripheral Nerve Regeneration

(2015) Jesse Isaacman-Beck et al.   NEURON

Mechanisms of distal axonal degeneration in peripheral neuropathies

(2015) Christopher R. Cashman et al.   NEUROSCIENCE LETTERS

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

Perineurial Glia

(2015) Sarah Kucenas   Cold Spring Harbor Perspectives in Biology

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

(2015) Jonathan Gilley et al.   Cell Reports

Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca 2+ Influx but Only Modestly Influenced by Mitochondria

(2015) Andrea Loreto et al.   Cell Reports

c-Jun activation in Schwann cells protects against loss of sensory axons in inherited neuropathy

(2014) Janina Hantke et al.   BRAIN

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Generation of Multipotent Induced Neural Crest by Direct Reprogramming of Human Postnatal Fibroblasts with a Single Transcription Factor

(2014) Yong Jun Kim et al.   Cell Stem Cell

Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes

(2014) Keisuke Hikosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Schwann Cells and Deleted in Colorectal Carcinoma Direct Regenerating Motor Axons Towards Their Original Path

(2014) A. F. Rosenberg et al.   JOURNAL OF NEUROSCIENCE

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

(2014) Thomas De Raedt et al.   NATURE

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

(2014) Ming Zhang et al.   NATURE GENETICS

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors

(2014) William Lee et al.   NATURE GENETICS

Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A

(2014) Robert Fledrich et al.   NATURE MEDICINE

Wallerian degeneration: an emerging axon death pathway linking injury and disease

(2014) Laura Conforti et al.   NATURE REVIEWS NEUROSCIENCE

Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration

(2014) Michio W. Painter et al.   NEURON

Malignant Peripheral Nerve Sheath Tumors

(2014) M. Farid et al.   ONCOLOGIST

Chemical Conversion of Human Fibroblasts into Functional Schwann Cells

(2014) Eva C. Thoma et al.   Stem Cell Reports

Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature

(2014) Andreas Argyriou et al.   Cancer Management and Research

Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge

(2013) Jose Antonio Gomez-Sanchez et al.   BRAIN

Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination

(2013) Florence R. Fricker et al.   BRAIN

Schwann cell phenotype is regulated by axon modality and central–peripheral location, and persists in vitro

(2013) T.M. Brushart et al.   EXPERIMENTAL NEUROLOGY

A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis

(2013) I. Fogh et al.   HUMAN MOLECULAR GENETICS

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

Sustained Activation of ERK1/2 MAPK in Oligodendrocytes and Schwann Cells Enhances Myelin Growth and Stimulates Oligodendrocyte Progenitor Expansion

(2013) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2

(2013) J. Gilley et al.   JOURNAL OF NEUROSCIENCE

Axon–soma communication in neuronal injury

(2013) Ida Rishal et al.   NATURE REVIEWS NEUROSCIENCE

Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin

(2013) Jing Yang et al.   NEURON

Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo

(2013) Stefan Milde et al.   Scientific Reports

The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction

(2013) Elisabetta Babetto et al.   Cell Reports

Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2

(2013) Stefan Milde et al.   PLOS BIOLOGY

c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling

(2012) Xavier Fontana et al.   JOURNAL OF CELL BIOLOGY

In Vivo Nerve-Macrophage Interactions Following Peripheral Nerve Injury

(2012) A. F. Rosenberg et al.   JOURNAL OF NEUROSCIENCE

p38 MAPK Activation Promotes Denervated Schwann Cell Phenotype and Functions as a Negative Regulator of Schwann Cell Differentiation and Myelination

(2012) D. P. Yang et al.   JOURNAL OF NEUROSCIENCE

Erbin Is Required for Myelination in Regenerated Axons after Injury

(2012) C. Liang et al.   JOURNAL OF NEUROSCIENCE

A role for Schwann cell–derived neuregulin-1 in remyelination

(2012) Ruth M Stassart et al.   NATURE NEUROSCIENCE

Assembly of a new growth cone after axotomy: the precursor to axon regeneration

(2012) Frank Bradke et al.   NATURE REVIEWS NEUROSCIENCE

Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types

(2012) Rosario Villegas et al.   Neural Development

A Central Role for the ERK-Signaling Pathway in Controlling Schwann Cell Plasticity and Peripheral Nerve Regeneration In Vivo

(2012) Ilaria Napoli et al.   NEURON

c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration

(2012) Peter J. Arthur-Farraj et al.   NEURON

Nicotinamide Mononucleotide Adenylyltransferase 2 (Nmnat2) Regulates Axon Integrity in the Mouse Embryo

(2012) Amy N. Hicks et al.   PLoS One

SCG10 is a JNK target in the axonal degeneration pathway

(2012) J. E. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

(2012) Xin Xiong et al.   PLOS BIOLOGY

Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration

(2011) Laura Conforti et al.   FEBS Journal

Wallerian degeneration: the innate-immune response to traumatic nerve injury

(2011) Shlomo Rotshenker   Journal of Neuroinflammation

Axonally Derived Neuregulin-1 Is Required for Remyelination and Regeneration after Nerve Injury in Adulthood

(2011) F. R. Fricker et al.   JOURNAL OF NEUROSCIENCE

MicroRNAs Modulate Schwann Cell Response to Nerve Injury by Reinforcing Transcriptional Silencing of Dedifferentiation-Related Genes

(2011) A. Viader et al.   JOURNAL OF NEUROSCIENCE

c-Jun expression in human neuropathies: a pilot study

(2011) Elspeth J. Hutton et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Involvement of placental growth factor in Wallerian degeneration

(2010) Linda Chaballe et al.   GLIA

Mechanisms of Axonal Spheroid Formation in Central Nervous System Wallerian Degeneration

(2010) Bogdan Beirowski et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Targeting NMNAT1 to Axons and Synapses Transforms Its Neuroprotective Potency In Vivo

(2010) E. Babetto et al.   JOURNAL OF NEUROSCIENCE

An assessment of mechanisms underlying peripheral axonal degeneration caused by aminoacyl-tRNA synthetase mutations

(2010) Morgane Stum et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Tight Junction Proteins in Human Schwann Cell Autotypic Junctions

(2009) Maria H. Alanne et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Nicotinamide Mononucleotide Adenylyltransferase Expression in Mitochondrial Matrix Delays Wallerian Degeneration

(2009) N. Yahata et al.   JOURNAL OF NEUROSCIENCE

Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration In Vivo

(2009) Y. Sasaki et al.   JOURNAL OF NEUROSCIENCE

Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity

(2009) Ashwin Woodhoo et al.   NATURE NEUROSCIENCE

The role of neurotrophic factors in nerve regeneration

(2009) Tessa Gordon   Neurosurgical Focus

A G Protein-Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination

(2009) K. R. Monk et al.   SCIENCE

The Wallerian degeneration slow ( Wlds ) gene does not attenuate disease in a mouse model of spinal muscular atrophy

(2008) Ferrill F. Rose et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differential effects of lentiviral vector-mediated overexpression of nerve growth factor and glial cell line-derived neurotrophic factor on regenerating sensory and motor axons in the transected peripheral nerve

(2008) Martijn R. Tannemaat et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

TheWldSgene delays axonal but not somatic degeneration in a rat glaucoma model

(2008) Bogdan Beirowski et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

(2008) Xiangyou Hu et al.   FASEB JOURNAL

Collagen XVIII and corneal reinnervation following keratectomy

(2008) Tohru Sakimoto et al.   FEBS LETTERS

Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection

(2008) Ikuo Tsunoda   Future Virology

E-cadherin expression in postnatal Schwann cells is regulated by the cAMP-dependent protein kinase a pathway

(2008) Audrita T. Crawford et al.   GLIA

c-Jun is a negative regulator of myelination

(2008) David B. Parkinson et al.   JOURNAL OF CELL BIOLOGY

Requirement of Myeloid Cells for Axon Regeneration

(2008) B. Barrette et al.   JOURNAL OF NEUROSCIENCE

The neuroprotective factor Wlds fails to mitigate distal axonal and neuromuscular junction (NMJ) defects in mouse models of spinal muscular atrophy

(2008) Shingo Kariya et al.   NEUROSCIENCE LETTERS

Comparison of cytokine expression profile during Wallerian degeneration of myelinated and unmyelinated peripheral axons

(2007) Therapoj Cheepudomwit et al.   NEUROSCIENCE LETTERS