Wallerian degeneration: an emerging axon death pathway linking injury and disease
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Title
Wallerian degeneration: an emerging axon death pathway linking injury and disease
Authors
Keywords
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Journal
NATURE REVIEWS NEUROSCIENCE
Volume 15, Issue 6, Pages 394-409
Publisher
Springer Nature
Online
2014-05-20
DOI
10.1038/nrn3680
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Note: Only part of the references are listed.- Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis
- (2013) Giovanni Nardo et al. BRAIN
- Vesicular Glycolysis Provides On-Board Energy for Fast Axonal Transport
- (2013) Diana Zala et al. CELL
- Efficient Retrograde Transport of Pseudorabies Virus within Neurons Requires Local Protein Synthesis in Axons
- (2013) Orkide O. Koyuncu et al. Cell Host & Microbe
- The challenges of axon survival: Introduction to the special issue on axonal degeneration
- (2013) Michael P. Coleman EXPERIMENTAL NEUROLOGY
- NAD+ acts on mitochondrial SirT3 to prevent axonal caspase activation and axonal degeneration
- (2013) Sébastien Magnifico et al. FASEB JOURNAL
- Diversification of NAD biological role : the importance of location
- (2013) Michele Di Stefano et al. FEBS Journal
- Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLDS-mediated axon protection independent of axonal mitochondria
- (2013) Brandon M. Kitay et al. HUMAN MOLECULAR GENETICS
- A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis
- (2013) I. Fogh et al. HUMAN MOLECULAR GENETICS
- Activation of the Innate Signaling Molecule MAVS by Bunyavirus Infection Upregulates the Adaptor Protein SARM1, Leading to Neuronal Death
- (2013) Piyali Mukherjee et al. IMMUNITY
- Neuronally-expressed Sarm1 regulates expression of inflammatory and antiviral cytokines in brains
- (2013) Chia-Wen Lin et al. Innate Immunity
- Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions
- (2013) J. Gerdts et al. JOURNAL OF NEUROSCIENCE
- Rescue of Peripheral and CNS Axon Defects in Mice Lacking NMNAT2
- (2013) J. Gilley et al. JOURNAL OF NEUROSCIENCE
- Sodium and Potassium Currents Influence Wallerian Degeneration of Injured Drosophila Axons
- (2013) B. Mishra et al. JOURNAL OF NEUROSCIENCE
- WldS and PGC-1 Regulate Mitochondrial Transport and Oxidation State after Axonal Injury
- (2013) K. C. O'Donnell et al. JOURNAL OF NEUROSCIENCE
- Maintaining energy homeostasis is an essential component of WldS-mediated axon protection
- (2013) Hua Shen et al. NEUROBIOLOGY OF DISEASE
- Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration
- (2013) Marek Ma et al. NEUROBIOLOGY OF DISEASE
- Regulation of Axon Degeneration after Injury and in Development by the Endogenous Calpain Inhibitor Calpastatin
- (2013) Jing Yang et al. NEURON
- Simultaneous Single-Sample Determination of NMNAT Isozyme Activities in Mouse Tissues
- (2013) Giuseppe Orsomando et al. PLoS One
- The Evolutionary Portrait of Metazoan NAD Salvage
- (2013) João Carneiro et al. PLoS One
- Insight into Molecular and Functional Properties of NMNAT3 Reveals New Hints of NAD Homeostasis within Human Mitochondria
- (2013) Roberta Felici et al. PLoS One
- Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo
- (2013) Stefan Milde et al. Scientific Reports
- The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction
- (2013) Elisabetta Babetto et al. Cell Reports
- Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2
- (2013) Stefan Milde et al. PLOS BIOLOGY
- Retinal ganglion cell survival and axon regeneration in WldS transgenic rats after optic nerve crush and lens injury
- (2012) Barbara Lorber et al. BMC NEUROSCIENCE
- T-cell death following immune activation is mediated by mitochondria-localized SARM
- (2012) P Panneerselvam et al. CELL DEATH AND DIFFERENTIATION
- Chemical Genetic-Mediated Spatial Regulation of Protein Expression in Neurons Reveals an Axonal Function for WldS
- (2012) Michael S. Cohen et al. CHEMISTRY & BIOLOGY
- A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity
- (2012) Yanshan Fang et al. CURRENT BIOLOGY
- WldS Prevents Axon Degeneration through Increased Mitochondrial Flux and Enhanced Mitochondrial Ca2+ Buffering
- (2012) Michelle A. Avery et al. CURRENT BIOLOGY
- Molecular characterization of porcine SARM1 and its role in regulating TLRs signaling during highly pathogenic porcine reproductive and respiratory syndrome virus infection in vivo
- (2012) Xiang Zhou et al. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
- Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot
- (2012) Shaoyun Zang et al. EMBO REPORTS
- The mechanism of axonal degeneration after perikaryal excitotoxic injury to the retina
- (2012) Natalie D. Bull et al. EXPERIMENTAL NEUROLOGY
- Axonal transport of adeno-associated viral vectors is serotype-dependent
- (2012) E A Salegio et al. GENE THERAPY
- Molecular chaperones protect against JNK- and Nmnat-regulated axon degeneration in Drosophila
- (2012) A. Rallis et al. JOURNAL OF CELL SCIENCE
- The NAMPT inhibitor FK866 reverts the damage in spinal cord injury
- (2012) Emanuela Esposito et al. Journal of Neuroinflammation
- A Model of Toxic Neuropathy in Drosophila Reveals a Role for MORN4 in Promoting Axonal Degeneration
- (2012) M. R. C. Bhattacharya et al. JOURNAL OF NEUROSCIENCE
- A Caspase Cascade Regulating Developmental Axon Degeneration
- (2012) D. J. Simon et al. JOURNAL OF NEUROSCIENCE
- WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity
- (2012) Jo Ann V Antenor-Dorsey et al. Molecular Neurodegeneration
- Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
- (2012) Hemmo Meyer et al. NATURE CELL BIOLOGY
- Mutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophy
- (2012) Isabelle Perrault et al. NATURE GENETICS
- NMNAT1 mutations cause Leber congenital amaurosis
- (2012) Marni J Falk et al. NATURE GENETICS
- Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis
- (2012) Pei-Wen Chiang et al. NATURE GENETICS
- Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration
- (2012) Robert K Koenekoop et al. NATURE GENETICS
- An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
- (2012) Sabrina M Lehmann et al. NATURE NEUROSCIENCE
- Will the real multiple sclerosis please stand up?
- (2012) Peter K. Stys et al. NATURE REVIEWS NEUROSCIENCE
- Intra-axonal calcium changes after axotomy in wild-type and slow Wallerian degeneration axons
- (2012) R. Adalbert et al. NEUROSCIENCE
- Animal Models of Peripheral Neuropathies
- (2012) Ahmet Höke Neurotherapeutics
- Reduced Axonal Transport and Increased Excitotoxic Retinal Ganglion Cell Degeneration in Mice Transgenic for Human Mutant P301S Tau
- (2012) Natalie D. Bull et al. PLoS One
- Nicotinamide Mononucleotide Adenylyltransferase 2 (Nmnat2) Regulates Axon Integrity in the Mouse Embryo
- (2012) Amy N. Hicks et al. PLoS One
- SCG10 is a JNK target in the axonal degeneration pathway
- (2012) J. E. Shin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway
- (2012) J. M. Osterloh et al. SCIENCE
- Mitochondria as a central sensor for axonal degenerative stimuli
- (2012) Felipe A. Court et al. TRENDS IN NEUROSCIENCES
- The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein
- (2012) Xin Xiong et al. PLOS BIOLOGY
- Mutations in a P-Type ATPase Gene Cause Axonal Degeneration
- (2012) Xianjun Zhu et al. PLoS Genetics
- Diapause Formation and Downregulation of Insulin-Like Signaling via DAF-16/FOXO Delays Axonal Degeneration and Neuronal Loss
- (2012) Andrea Calixto et al. PLoS Genetics
- Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy
- (2011) Jone López-Erauskin et al. ANNALS OF NEUROLOGY
- Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence
- (2011) Porkodi Panneerselvam et al. BIOCHEMICAL JOURNAL
- Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot–Marie–Tooth disease type 1X
- (2011) Janos Groh et al. BRAIN
- WldS Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis
- (2011) J. Wu et al. DIABETES
- Wld S protects against peripheral neuropathy and retinopathy in an experimental model of diabetes in mice
- (2011) S. S. Zhu et al. DIABETOLOGIA
- Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration
- (2011) Laura Conforti et al. FEBS Journal
- CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy
- (2011) M. Cecilia Ljungberg et al. HUMAN MOLECULAR GENETICS
- NMNAT suppresses Tau-induced neurodegeneration by promoting clearance of hyperphosphorylated Tau oligomers in a Drosophila model of tauopathy
- (2011) Yousuf O. Ali et al. HUMAN MOLECULAR GENETICS
- Nicotinamide Mononucleotide Adenylyltransferase Is a Stress Response Protein Regulated by the Heat Shock Factor/Hypoxia-inducible Factor 1α Pathway
- (2011) Yousuf O. Ali et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Image-based Screening Identifies Novel Roles for IκB Kinase and Glycogen Synthase Kinase 3 in Axonal Degeneration
- (2011) Josiah Gerdts et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells
- (2011) Andrey Nikiforov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology
- (2011) Chiung-Ya Chen et al. JOURNAL OF CELL BIOLOGY
- Age-Related Alterations in Neurons of the Mouse Retina
- (2011) M. A. Samuel et al. JOURNAL OF NEUROSCIENCE
- Axonal Degeneration Is Mediated by the Mitochondrial Permeability Transition Pore
- (2011) S. A. Barrientos et al. JOURNAL OF NEUROSCIENCE
- Wallerian degeneration slow mouse neurons are protected against cell death caused by mechanisms involving mitochondrial electron transport dysfunction
- (2011) Shinji Tokunaga et al. JOURNAL OF NEUROSCIENCE RESEARCH
- ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation
- (2011) Shuji Wakatsuki et al. NATURE CELL BIOLOGY
- A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
- (2011) Ivana Nikić et al. NATURE MEDICINE
- Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death
- (2011) P. B. Verghese et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Wallerian degeneration of zebrafish trigeminal axons in the skin is required for regeneration and developmental pruning
- (2010) S. M. Martin et al. DEVELOPMENT
- Axonal Degeneration Is Blocked by Nicotinamide Mononucleotide Adenylyltransferase (Nmnat) Protein Transduction into Transected Axons
- (2010) Yo Sasaki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The WldSmutation delays anterograde, but not retrograde, axonal degeneration of the dopaminergic nigro-striatal pathwayin vivo
- (2010) Hsiao-Chun Cheng et al. JOURNAL OF NEUROCHEMISTRY
- Targeting NMNAT1 to Axons and Synapses Transforms Its Neuroprotective Potency In Vivo
- (2010) E. Babetto et al. JOURNAL OF NEUROSCIENCE
- Amyloid Precursor Protein Cleavage-Dependent and -Independent Axonal Degeneration Programs Share a Common Nicotinamide Mononucleotide Adenylyltransferase 1-Sensitive Pathway
- (2010) B. P. S. Vohra et al. JOURNAL OF NEUROSCIENCE
- Axonal Degeneration Is Regulated by the Apoptotic Machinery or a NAD+-Sensitive Pathway in Insects and Mammals
- (2010) Z. Schoenmann et al. JOURNAL OF NEUROSCIENCE
- An assessment of mechanisms underlying peripheral axonal degeneration caused by aminoacyl-tRNA synthetase mutations
- (2010) Morgane Stum et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration
- (2010) Gerd Meyer zu Horste et al. NEUROBIOLOGY OF DISEASE
- Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons
- (2010) Jonathan Gilley et al. PLOS BIOLOGY
- Early ultrastructural defects of axons and axon-glia junctions in mice lacking expression ofCnp1
- (2009) Julia M. Edgar et al. GLIA
- Enzymes in the NAD+Salvage Pathway Regulate SIRT1 Activity at Target Gene Promoters
- (2009) Tong Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- WldSrequires Nmnat1 enzymatic activity and N16–VCP interactions to suppress Wallerian degeneration
- (2009) Michelle A. Avery et al. JOURNAL OF CELL BIOLOGY
- WldSprotein requires Nmnat activity and a short N-terminal sequence to protect axons in mice
- (2009) Laura Conforti et al. JOURNAL OF CELL BIOLOGY
- Non-Nuclear WldS Determines Its Neuroprotective Efficacy for Axons and Synapses In Vivo
- (2009) B. Beirowski et al. JOURNAL OF NEUROSCIENCE
- Nicotinamide Mononucleotide Adenylyltransferase Expression in Mitochondrial Matrix Delays Wallerian Degeneration
- (2009) N. Yahata et al. JOURNAL OF NEUROSCIENCE
- Transgenic Mice Expressing the Nmnat1 Protein Manifest Robust Delay in Axonal Degeneration In Vivo
- (2009) Y. Sasaki et al. JOURNAL OF NEUROSCIENCE
- Nicotinamide Mononucleotide Adenylyl Transferase-Mediated Axonal Protection Requires Enzymatic Activity But Not Increased Levels of Neuronal Nicotinamide Adenine Dinucleotide
- (2009) Y. Sasaki et al. JOURNAL OF NEUROSCIENCE
- The Immune Adaptor Molecule SARM Modulates Tumor Necrosis Factor Alpha Production and Microglia Activation in the Brainstem and Restricts West Nile Virus Pathogenesis
- (2009) K. J. Szretter et al. JOURNAL OF VIROLOGY
- APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
- (2009) Anatoly Nikolaev et al. NATURE
- A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration
- (2009) Bradley R Miller et al. NATURE NEUROSCIENCE
- Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity
- (2009) Tingting Yan et al. NEUROCHEMISTRY INTERNATIONAL
- Prion disease development in slow Wallerian degeneration (WldS) mice
- (2009) Sandra Gültner et al. NEUROSCIENCE LETTERS
- The Wallerian degeneration slow ( Wlds ) gene does not attenuate disease in a mouse model of spinal muscular atrophy
- (2008) Ferrill F. Rose et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- TheWldSgene delays axonal but not somatic degeneration in a rat glaucoma model
- (2008) Bogdan Beirowski et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Axonal degeneration as a self-destructive defense mechanism against neurotropic virus infection
- (2008) Ikuo Tsunoda Future Virology
- Nmnat Delays Axonal Degeneration Caused by Mitochondrial and Oxidative Stress
- (2008) C. Press et al. JOURNAL OF NEUROSCIENCE
- NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration
- (2008) R. Grace Zhai et al. NATURE
- The neuroprotective factor Wlds fails to mitigate distal axonal and neuromuscular junction (NMJ) defects in mouse models of spinal muscular atrophy
- (2008) Shingo Kariya et al. NEUROSCIENCE LETTERS
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