DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration

ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

(2019) Joseph R. Klim et al.   NATURE NEUROSCIENCE

Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration

(2019) Ze’ev Melamed et al.   NATURE NEUROSCIENCE

Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence

(2019) Marshall Lukacs et al.   EXPERIMENTAL NEUROLOGY

Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia

(2019) Peter Huppke et al.   EXPERIMENTAL NEUROLOGY

Axon degeneration

(2019) Aaron DiAntonio   PAIN

DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury

(2019) Jung Eun Shin et al.   NEUROBIOLOGY OF DISEASE

Intrinsic Neuronal Stress Response Pathways in Injury and Disease

(2018) Madeline M. Farley et al.   Annual Review of Pathology-Mechanisms of Disease

Primary Traumatic Axonopathy in Mice Subjected to Impact Acceleration: A Reappraisal of Pathology and Mechanisms with High-Resolution Anatomical Methods

(2018) Nikolaos K. Ziogas et al.   JOURNAL OF NEUROSCIENCE

Palmitoylation enables MAPK-dependent proteostasis of axon survival factors

(2018) Daniel W. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy

(2017) Elliot Turkiew et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons

(2017) Derek S. Welsbie et al.   NEURON

Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture

(2017) Thomas Misgeld et al.   NEURON

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

(2017) Claire E. Le Pichon et al.   Science Translational Medicine

Screening with an NMNAT2-MSD platform identifies small molecules that modulate NMNAT2 levels in cortical neurons

(2017) Yousuf O. Ali et al.   Scientific Reports

Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

(2017) Jiaxing Li et al.   eLife

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

(2017) Lauren J Walker et al.   eLife

Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice

(2016) Stefanie Geisler et al.   BRAIN

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lackingSarm1

(2016) Nils Henninger et al.   BRAIN

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

(2016) Josiah Gerdts et al.   NEURON

NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies

(2016) Yousuf O. Ali et al.   PLOS BIOLOGY

NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion

(2016) Yo Sasaki et al.   eLife

An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK

(2016) Yan Hao et al.   eLife

Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

(2015) Jing Yang et al.   CELL

Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury

(2015) Vera Valakh et al.   NEUROBIOLOGY OF DISEASE

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

(2015) Jonathan Gilley et al.   Cell Reports

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

The Axon-Protective WLDS Protein Partially Rescues Mitochondrial Respiration and Glycolysis After Axonal Injury

(2014) Katharina Godzik et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mitochondrial Dysfunction Induces Sarm1-Dependent Cell Death in Sensory Neurons

(2014) D. W. Summers et al.   JOURNAL OF NEUROSCIENCE

DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury

(2014) Kimberly A. Fernandes et al.   NEUROBIOLOGY OF DISEASE

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration

(2013) Christine D. Pozniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

(2013) T. A. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

(2013) D. S. Welsbie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2

(2013) Stefan Milde et al.   PLOS BIOLOGY

A Conditioning Lesion Protects Axons from Degeneration via the Wallenda/DLK MAP Kinase Signaling Cascade

(2012) X. Xiong et al.   JOURNAL OF NEUROSCIENCE

Dual Leucine Zipper Kinase Is Required for Retrograde Injury Signaling and Axonal Regeneration

(2012) Jung Eun Shin et al.   NEURON

SCG10 is a JNK target in the axonal degeneration pathway

(2012) J. E. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

(2011) M. Cecilia Ljungberg et al.   HUMAN MOLECULAR GENETICS

Image-based Screening Identifies Novel Roles for IκB Kinase and Glycogen Synthase Kinase 3 in Axonal Degeneration

(2011) Josiah Gerdts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

(2011) Arundhati Sengupta Ghosh et al.   JOURNAL OF CELL BIOLOGY

Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

(2010) Xin Xiong et al.   JOURNAL OF CELL BIOLOGY

Calcium and Cyclic AMP Promote Axonal Regeneration in Caenorhabditis elegans and Require DLK-1 Kinase

(2010) A. Ghosh-Roy et al.   JOURNAL OF NEUROSCIENCE

The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration

(2009) Dong Yan et al.   CELL

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

(2009) Bradley R Miller et al.   NATURE NEUROSCIENCE

Axon Regeneration Requires a Conserved MAP Kinase Pathway

(2009) M. Hammarlund et al.   SCIENCE