Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights

(2017) David S. Hewings et al.   FEBS Journal

Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1

(2017) Katja K. Dove et al.   STRUCTURE

Mechanism and disease association of E2-conjugating enzymes: lessons from UBE2T and UBE2L3

(2016) A. F. Alpi et al.   BIOCHEMICAL JOURNAL

Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation

(2016) Bernhard C. Lechtenberg et al.   NATURE

Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation

(2016) Kuan-Chuan Pao et al.   Nature Chemical Biology

The PHR proteins: intracellular signaling hubs in neuronal development and axon degeneration

(2016) Brock Grill et al.   Neural Development

Orthogonal Thiol Functionalization at a Single Atomic Center for Profiling Transthiolation Activity of E1 Activating Enzymes

(2015) Mathew Stanley et al.   ACS Chemical Biology

Enzyme Inhibitor Discovery by Activity-Based Protein Profiling

(2014) Micah J. Niphakis et al.   Annual Review of Biochemistry

Wallerian degeneration: an emerging axon death pathway linking injury and disease

(2014) Laura Conforti et al.   NATURE REVIEWS NEUROSCIENCE

Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer

(2013) Shaun K. Olsen et al.   MOLECULAR CELL

Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP

(2013) Benjamin Stieglitz et al.   NATURE

The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction

(2013) Elisabetta Babetto et al.   Cell Reports

Subcellular Localization Determines the Stability and Axon Protective Capacity of Axon Survival Factor Nmnat2

(2013) Stefan Milde et al.   PLOS BIOLOGY

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

(2012) Benjamin Stieglitz et al.   EMBO REPORTS

Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

(2012) Jonathan N. Pruneda et al.   MOLECULAR CELL

Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

(2012) Anna Plechanovová et al.   NATURE

Identification of cross-linked peptides from complex samples

(2012) Bing Yang et al.   NATURE METHODS

BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

(2012) Xin Xiong et al.   PLOS BIOLOGY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

(2011) Dawn M. Wenzel et al.   NATURE

Ubiquitination of Substrates by Esterification

(2011) Xiaoli Wang et al.   TRAFFIC

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Ubiquitylation of an ERAD Substrate Occurs on Multiple Types of Amino Acids

(2010) Yuichiro Shimizu et al.   MOLECULAR CELL

Substrate-Assisted Inhibition of Ubiquitin-like Protein-Activating Enzymes: The NEDD8 E1 Inhibitor MLN4924 Forms a NEDD8-AMP Mimetic In Situ

(2010) James E. Brownell et al.   MOLECULAR CELL

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols