Polycomb repression regulates Schwann cell proliferation and axon regeneration after nerve injury

mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation

(2018) Camilla Norrmén et al.   JOURNAL OF NEUROSCIENCE

A histone deacetylase 3–dependent pathway delimits peripheral myelin growth and functional regeneration

(2018) Xuelian He et al.   NATURE MEDICINE

Epigenetic Control of Schwann Cells

(2018) Ki H. Ma et al.   NEUROSCIENTIST

After Nerve Injury, Lineage Tracing Shows That Myelin and Remak Schwann Cells Elongate Extensively and Branch to Form Repair Schwann Cells, Which Shorten Radically on Remyelination

(2017) Jose A. Gomez-Sanchez et al.   JOURNAL OF NEUROSCIENCE

STAT3 Controls the Long-Term Survival and Phenotype of Repair Schwann Cells during Nerve Regeneration

(2017) Cristina Benito et al.   JOURNAL OF NEUROSCIENCE

Significance of H3K27me3 loss in the diagnosis of malignant peripheral nerve sheath tumors

(2017) Melike Pekmezci et al.   MODERN PATHOLOGY

The Wound Microenvironment Reprograms Schwann Cells to Invasive Mesenchymal-like Cells to Drive Peripheral Nerve Regeneration

(2017) Melanie P. Clements et al.   NEURON

Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury

(2017) Amanda Brosius Lutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration

(2017) Valérie Brügger et al.   Nature Communications

Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury

(2017) Peter J. Arthur-Farraj et al.   Cell Reports

The Challenge of Cancer Genomics in Rare Nervous System Neoplasms

(2016) Steven L. Carroll   AMERICAN JOURNAL OF PATHOLOGY

CNTF protects neurons from hypoxic injury through the activation of STAT3pTyr705

(2016) Ying Li Gu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells

(2016) Jianbo Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury

(2016) K. H. Ma et al.   JOURNAL OF NEUROSCIENCE

The repair Schwann cell and its function in regenerating nerves

(2016) K. R. Jessen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Loss of H3K27 tri-methylation is a diagnostic marker for malignant peripheral nerve sheath tumors and an indicator for an inferior survival

(2016) Arjen H G Cleven et al.   MODERN PATHOLOGY

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors

(2016) Ami V. Patel et al.   EBioMedicine

Temporal Analysis of Gene Expression in the Murine Schwann Cell Lineage and the Acutely Injured Postnatal Nerve

(2016) Anjali Balakrishnan et al.   PLoS One

Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves

(2015) Anne-Laure Cattin et al.   CELL

PRC2 mediated H3K27 methylations in cellular identity and cancer

(2015) Eric Conway et al.   CURRENT OPINION IN CELL BIOLOGY

The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration

(2015) Giulia Ronchi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Intrinsic facilitation of adult peripheral nerve regeneration by the Sonic hedgehog morphogen

(2015) Jose A. Martinez et al.   EXPERIMENTAL NEUROLOGY

Differential Sox10 genomic occupancy in myelinating glia

(2015) Camila Lopez-Anido et al.   GLIA

Microprocessor Complex Subunit DiGeorge Syndrome Critical Region Gene 8 (Dgcr8) Is Required for Schwann Cell Myelination and Myelin Maintenance

(2015) Hsin-Pin Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic Regulation of Schwann Cell Enhancers after Peripheral Nerve Injury

(2015) Holly A. Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

(2015) Jose A. Gomez-Sanchez et al.   JOURNAL OF CELL BIOLOGY

Inactivation of Protein Tyrosine Phosphatase Receptor Type Z by Pleiotrophin Promotes Remyelination through Activation of Differentiation of Oligodendrocyte Precursor Cells

(2015) K. Kuboyama et al.   JOURNAL OF NEUROSCIENCE

Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2

(2015) K. H. Ma et al.   JOURNAL OF NEUROSCIENCE

Let-7 microRNAs Regenerate Peripheral Nerve Regeneration by Targeting Nerve Growth Factor

(2015) Shiying Li et al.   MOLECULAR THERAPY

Combined suppression of CASP2 and CASP6 protects retinal ganglion cells from apoptosis and promotes axon regeneration through CNTF-mediated JAK/STAT signalling

(2014) Vasanthy Vigneswara et al.   BRAIN

Contrasting the Glial Response to Axon Injury in the Central and Peripheral Nervous Systems

(2014) Amanda Brosius Lutz et al.   DEVELOPMENTAL CELL

A comparative morphological, electrophysiological and functional analysis of axon regeneration through peripheral nerve autografts genetically modified to overexpress BDNF, CNTF, GDNF, NGF, NT3 or VEGF

(2014) Stefan A. Hoyng et al.   EXPERIMENTAL NEUROLOGY

HDAC1 and HDAC2 Control the Specification of Neural Crest Cells into Peripheral Glia

(2014) C. Jacob et al.   JOURNAL OF NEUROSCIENCE

PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

(2014) Thomas De Raedt et al.   NATURE

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

(2014) Ming Zhang et al.   NATURE GENETICS

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors

(2014) William Lee et al.   NATURE GENETICS

Soluble neuregulin-1 modulates disease pathogenesis in rodent models of Charcot-Marie-Tooth disease 1A

(2014) Robert Fledrich et al.   NATURE MEDICINE

Neuregulin-1 overexpression and Trp53 haploinsufficiency cooperatively promote de novo malignant peripheral nerve sheath tumor pathogenesis

(2013) Stephanie N. Brosius et al.   ACTA NEUROPATHOLOGICA

Transgenic Mice Overexpressing Neuregulin-1 Model Neurofibroma-Malignant Peripheral Nerve Sheath Tumor Progression and Implicate Specific Chromosomal Copy Number Variations in Tumorigenesis

(2013) Syed J. Kazmi et al.   AMERICAN JOURNAL OF PATHOLOGY

Epigenetic induction of the Ink4a/Arf locus prevents Schwann cell overproliferation during nerve regeneration and after tumorigenic challenge

(2013) Jose Antonio Gomez-Sanchez et al.   BRAIN

Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner

(2013) Huafeng Xie et al.   Cell Stem Cell

The Neuregulin-Rac-MKK7 pathway regulates antagonistic c-jun/Krox20 expression in Schwann cell dedifferentiation

(2013) Yoon Kyung Shin et al.   GLIA

A Critical Role for Macrophages Near Axotomized Neuronal Cell Bodies in Stimulating Nerve Regeneration

(2013) J. P. Niemi et al.   JOURNAL OF NEUROSCIENCE

Ciliary neurotrophic factor and fibroblast growth factor increase the speed and number of regenerating axons after optic nerve injury in adultRana pipiens

(2013) Giam S. Vega-Meléndez et al.   JOURNAL OF NEUROSCIENCE RESEARCH

STAT3 integrates cytokine and neurotrophin signals to promote sympathetic axon regeneration

(2013) Michael J. Pellegrino et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor

(2013) Brian Biehs et al.   NATURE CELL BIOLOGY

Mechanisms regulating the development of oligodendrocytes and central nervous system myelin

(2013) S. Mitew et al.   NEUROSCIENCE

Effect of Delayed Peripheral Nerve Repair on Nerve Regeneration, Schwann Cell Function and Target Muscle Recovery

(2013) Samuel Jonsson et al.   PLoS One

Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration

(2013) M Leibinger et al.   Cell Death & Disease

Injury Signals Cooperate with Nf1 Loss to Relieve the Tumor-Suppressive Environment of Adult Peripheral Nerve

(2013) Sara Ribeiro et al.   Cell Reports

Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor

(2012) Robin D. S. Doddrell et al.   GLIA

c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling

(2012) Xavier Fontana et al.   JOURNAL OF CELL BIOLOGY

Local axonal function of STAT3 rescues axon degeneration in thepmnmodel of motoneuron disease

(2012) Bhuvaneish Thangaraj Selvaraj et al.   JOURNAL OF CELL BIOLOGY

The Nucleosome Remodeling and Deacetylase Chromatin Remodeling (NuRD) Complex Is Required for Peripheral Nerve Myelination

(2012) H. Hung et al.   JOURNAL OF NEUROSCIENCE

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

(2012) Laurens Kruidenier et al.   NATURE

A role for Schwann cell–derived neuregulin-1 in remyelination

(2012) Ruth M Stassart et al.   NATURE NEUROSCIENCE

A Central Role for the ERK-Signaling Pathway in Controlling Schwann Cell Plasticity and Peripheral Nerve Regeneration In Vivo

(2012) Ilaria Napoli et al.   NEURON

c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration

(2012) Peter J. Arthur-Farraj et al.   NEURON

Modulation of MAPK and Akt signaling pathways in proximal segment of injured sciatic nerves

(2012) Guixin Sun et al.   NEUROSCIENCE LETTERS

The MMP-9/TIMP-1 Axis Controls the Status of Differentiation and Function of Myelin-Forming Schwann Cells in Nerve Regeneration

(2012) Youngsoon Kim et al.   PLoS One

Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart

(2011) Aibin He et al.   CIRCULATION RESEARCH

Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration

(2011) J Homs et al.   GENE THERAPY

EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair

(2011) E. Ezhkova et al.   GENES & DEVELOPMENT

Wallerian degeneration: the innate-immune response to traumatic nerve injury

(2011) Shlomo Rotshenker   Journal of Neuroinflammation

A Nuclear Variant of ErbB3 Receptor Tyrosine Kinase Regulates Ezrin Distribution and Schwann Cell Myelination

(2011) T. Adilakshmi et al.   JOURNAL OF NEUROSCIENCE

Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: Identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration

(2010) Benoit Barrette et al.   BRAIN BEHAVIOR AND IMMUNITY

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

HOXA13 Promotes Cancer Cell Growth and Predicts Poor Survival of Patients with Esophageal Squamous Cell Carcinoma

(2009) Z.-D. Gu et al.   CANCER RESEARCH

A spatio-temporal analysis of motoneuron survival, axonal regeneration and neurotrophic factor expression after lumbar ventral root avulsion and implantation

(2009) R. Eggers et al.   EXPERIMENTAL NEUROLOGY

Polycomb protein Ezh2 regulates pancreatic  -cell Ink4a/Arf expression and regeneration in diabetes mellitus

(2009) H. Chen et al.   GENES & DEVELOPMENT

Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy

(2009) Christian M. Simon et al.   HUMAN MOLECULAR GENETICS

Activation of MAP kinases, Akt and PDGF receptors in injured peripheral nerves

(2009) Takashi Yamazaki et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Exogenous CNTF stimulates axon regeneration of retinal ganglion cells partially via endogenous CNTF

(2009) Adrienne Müller et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ROLE OF CHRONIC SCHWANN CELL DENERVATION IN POOR FUNCTIONAL RECOVERY AFTER NERVE INJURIES AND EXPERIMENTAL STRATEGIES TO COMBAT IT

(2009) Olawale A.R. Sulaiman et al.   NEUROSURGERY

Treatment of transected peripheral nerves with artemin improved motor neuron regeneration, but did not reduce nerve injury-induced pain behaviour

(2009) Johan Widenfalk et al.   SCANDINAVIAN JOURNAL OF PLASTIC AND RECONSTRUCTIVE SURGERY AND HAND SURGERY

NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F

(2008) S. Parrinello et al.   GENES & DEVELOPMENT

Increase of MCP-1 (CCL2) in myelin mutant Schwann cells is mediated by MEK-ERK signaling pathway

(2008) Stefan Fischer et al.   GLIA

Long-term changes in neurotrophic factor expression in distal nerve stump following denervation and reinnervation with motor or sensory nerve

(2008) B. Michalski et al.   JOURNAL OF NEUROCHEMISTRY

Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: Axon-dependent removal of newly generated Schwann cells by apoptosis

(2008) David P. Yang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE