Article
Chemistry, Physical
Debkumar Bera, Mousumi Baruah, Asish K. Dehury, Animesh Samanta, Yatendra S. Chaudhary, Nirmal Goswami
Summary: Nanoscale assembly of ultrasmall metal nanoclusters using molecular forces has been shown to be a powerful strategy to manipulate their properties in various dimensions. In this study, we demonstrate the formation of kinetically trapped assemblies with enhanced photoluminescence and extended this principle to other materials. We also show a thermal energy driven process to isolate these assemblies, which exhibit thermodynamic stability and unique properties. Our strategy may have broader applications in creating different MNC-based assemblies with unforeseen arrangements and properties.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Multidisciplinary Sciences
Jianqin Wan, Jiahao Liang, Shiyun Xian, Xiao Gong, Hangxiang Wang
Summary: This study designed and prepared solid-state fluorescent organosilica nanoparticles (ONs) which can be applied in fingerprint detection, white light-emitting diodes (WLEDs) fabrication, and cellular imaging. The ultrasmall ONs specifically localized to lysosomes, making them potential candidates for biological and photoelectric applications.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Paul Rocchi, Delphine Brichart-Vernos, Francois Lux, Isabelle Morfin, Laurent David, Claire Rodriguez-Lafrasse, Olivier Tillement
Summary: This study developed a multimodal ultrasmall nanoparticle, CuPRiX, for cancer treatment. CuPRiX nanoparticles can prevent tumor cell dissemination and metastasis by depleting copper in tumors, and they also increase the sensitivity of tumors to radiotherapy.
Article
Biotechnology & Applied Microbiology
Fangman Chen, Fan Zhang, Yanbin Wang, Jiahui Peng, Lei Cao, Qian Mei, Mingfeng Ge, Li Li, Meiwan Chen, Wen-fei Dong, Zhimin Chang
Summary: In this study, mesoporous organosilica nanoparticles (MON) coated with biomimetic cancer cell membrane were developed for controlled release of cisplatin and reduction inactivation, aiming to enhance platinum-based chemotherapy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Prabhusrinivas Yavvari, Anna Laporte, Laura Elomaa, Fabian Schraufstetter, Inga Pacharzina, Aline Dominique Daberkow, Anke Hoppensack, Marie Weinhart
Summary: Vascular-disrupting agents are an interesting class of anticancer compounds that can prevent new blood vessel formation and disrupt existing vasculature in tumors. The lack of appropriate in vitro angiogenesis models has hindered the validation of these drugs' vascular disruption properties. This study reports a novel indirect coculture model that successfully forms three-dimensional vascular-like networks for testing the effects of antiangiogenic and vascular disrupting agents.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Julie Blatt, Jennifer E. Brondon, Elizabeth L. Nieman, Kynlon Phillips, Arti Pandya
Summary: Vascular anomalies are developmental abnormalities of veins, arteries, lymphatics, or capillaries caused by mutations in genes involved in angiogenesis. The current treatments targeting these genes are limited. This study reviewed the literature to identify medications with antiangiogenic activity from conventional and traditional medicine, and found fewer than 50 drugs that showed credible human activity in treating vascular anomalies. Further research is needed to explore the potential of these drugs for repurposing.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Yuanyuan Ma, Zheng Su, Liming Zhou, Liangcan He, Zhenyu Hou, Jianhua Zou, Yu Cai, Di Chang, Jinbing Xie, Chen Zhu, Wenpei Fan, Xiaoyuan Chen, Shenghong Ju
Summary: This study achieved targeted delivery of cisplatin using biocompatible and biodegradable hollow mesoporous organosilica (HMOS) nanoparticles by blocking the pores with a bimetallic Zn2+/Cu2+ co-doped metal-organic framework (MOF). The MOF decomposes in the acidic tumor microenvironment to release cisplatin for chemotherapy, while the released Cu2+ depletes intracellular glutathione (GSH) and catalyzes the decomposition of intratumoral H2O2 into highly toxic •OH for chemodynamic therapy. The reduced GSH also protects the •OH from scavenging, enhancing the chemodynamic therapy effect.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Behnam Gholipour, Afsaneh Zonouzi, Sadegh Rostamnia, Xiao Liu
Summary: In this study, a dual catalysis method was used to convert primary aromatic alcohols to amides using ultrasmall Pd-NPs inside hybrid mesoporous organosilica nanotubes. The catalyst exhibited excellent performance and high stability in water. The catalytic activity towards the tandem oxidation of alcohols to their corresponding amides was evaluated, and high yields were obtained. The structure of the organosilica nanotubes containing palladium nanoparticles was investigated using various characterization techniques. Catalyst recycling tests showed that the catalytic power was preserved after multiple cycles with a slight decrease in activity.
Article
Chemistry, Multidisciplinary
Lili Feng, Bin Liu, Rui Xie, Dongdong Wang, Cheng Qian, Weiqiang Zhou, Jiawei Liu, Deblin Jana, Piaoping Yang, Yanli Zhao
Summary: The newly introduced TME-modulated nanozyme combines photothermal therapy, photodynamic therapy, and chemodynamic therapy for efficient tumor treatment in the tumor microenvironment. This all-in-one nanozyme demonstrates promising therapeutic effects and offers a new perspective for the design of other TME-based anticancer strategies.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Oncology
Yun Liu, Yang Li, Yuxi Wang, Congcong Lin, Dan Zhang, Juncheng Chen, Liang Ouyang, Fengbo Wu, Jifa Zhang, Lei Chen
Summary: This perspective provides an overview of the development of VEGFR dual-target inhibitors, including rational target combinations, drug discovery strategies, structure-activity relationships, and future directions.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Chemistry, Physical
Jia Ren, Xiaorui Jiao, Mahmood Hassan Akhtar, Muhammad Azhar Hayat Nawaz, Na Yang, Chang Liu, Xin Wen, Ying Li, Ning Liu, Cong Yu
Summary: In this study, a multifunctional organosilica nanoagent was developed to specifically target tumor cells and induce cellular oxidation and apoptosis. The nanoagent released copper ions and arginine, which in turn converted hydrogen peroxide to hydroxyl radicals at the tumor sites. This novel approach achieved efficient cancer therapy with minimal side effects.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Review
Oncology
Ting Yang, Hongqi Xiao, Xiaoxia Liu, Zhihui Wang, Qingbai Zhang, Nianjin Wei, Xinggang Guo
Summary: The normalization of tumor blood vessels has shown to reduce tumor invasion and metastasis while enhancing the effectiveness of chemotherapy, radiation therapy, and immunotherapy. By maintaining the balance between proangiogenic and antiangiogenic factors and targeting endothelial cell metabolism, microRNAs, and the extracellular matrix, the normalization of tumor blood vessels can be promoted, leading to improved immunotherapy outcomes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zhi-Peng Han, Shiqi Wang, Qiming Sun, Xiao-Ping Xu, Shun-Jun Ji
Summary: A series of azoxy compounds were constructed via facile coupling reactions using cost-effective N-methoxyformamide and nitroso compounds over Cu-based catalysts, with high product yields and excellent tolerance of functional groups. A mesoporous silica nanosphere-encapsulated ultrasmall Cu (Cu@MSN) catalyst was developed and exhibited remarkably enhanced catalytic activity and superior recycling stability compared to copper salt catalysts. This work provides a green and efficient method for the construction of azoxy compounds and opens up new prospects for the application of nanoporous materials confined metal catalysts in organic synthesis.
Article
Chemistry, Multidisciplinary
Zhiguo Gao, Yaojia Li, Zhikun Liu, Yu Zhang, Fanghui Chen, Peijing An, Wenjun Lu, Jinzhong Hu, Chaoqun You, Jun Xu, Xiangyang Zhang, Baiwang Sun
Summary: A novel material TTASi and its application in catalysis were reported, showing high selectivity and efficiency, with potential for in vivo applications in biological systems.
Article
Pharmacology & Pharmacy
Jie Lin, Shi-Wei Li, Jing Zhang, Fu-Hao Chu, Cheng-Ze Li, Zhi-Xu Bie, Han-Lu Tang, Shan Gao, Ping Li, Meng-Ting Liao, Tian-Xi Xin, Fu Zhao, Pi-Nan Liu, Xia Ding
Summary: This study evaluated the antitumor efficacy of Qu-Du-San-Jie (QDSJ) decoction, a traditional Chinese medicine formula, on neurofibromatosis type 2 (NF2)-associated vestibular schwannomas (VSs). The study identified the components of QDSJ and their targets using ultra high-performance liquid chromatography-mass spectroscopy (UHPLC-MS) analysis. It also investigated the potential mechanisms of QDSJ in treating NF2-associated VS through network pharmacology. The results showed that QDSJ induced cell death and apoptosis of schwannoma cells in vitro and suppressed tumor growth in vivo. QDSJ was found to regulate necroptosis, apoptosis, cell cycle, angiogenesis, adherens junction, and neuroactive ligand-receptor interaction. Overall, QDSJ decoction showed significant antitumor activity against NF2-associated schwannoma and has the potential to be tested in future clinical trials.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shumin Li, Liang Zhao, Yining Yao, Zhengying Gu, Chao Liu, Wenli Hu, Ye Zhang, Qian Zhao, Chengzhong Yu
Summary: The integration of different types of metal-organic frameworks (MOFs) into hybrid MOF-on-MOF heterostructures has been extensively studied to increase the diversity of MOF-on-MOF hybrids. This study reports the structure regulation of MOF-on-MOF hybrids by controlling the nucleation and growth of guest MOFs. By using ZIF-90 as the host and ZIF-8 as the guest, binary ZIF-90@ZIF-8 complexes with different structures were successfully synthesized, enhancing the structural diversity of MOF-on-MOF materials.
Review
Chemistry, Multidisciplinary
Jianing Li, Wanyue Lu, Yannan Yang, Ruiqing Xiang, Yun Ling, Chengzhong Yu, Yaming Zhou
Summary: Nano-immunotherapy, a combination of nanotechnology and immunotherapy, is considered a highly promising strategy for cancer treatment. Hybrid nanomaterials, consisting of different organic and inorganic components, have been engineered with integrated functions and potential for boosting cancer immunotherapy. This review summarizes the use of hybrid nanomaterials in cancer immunotherapy, including metal-organic frameworks, metal-phenolic networks, organosilica nanoparticles, metallofullerene nanomaterials, polymer-lipid, and biomacromolecule-based hybrids. The review also discusses the combination of immunotherapy with different therapies based on hybrid nanomaterials, such as chemotherapy, photothermal therapy, and radiotherapy.
Article
Chemistry, Multidisciplinary
Tao Yang, Yaowei Jin, Yingchu Wang, Aiguo Kong, Yue Chen, Yingying Zou, Chao Liu, Guangfeng Wei, Chengzhong Yu
Summary: A covalent furan-benzimidazole-linked polymer (Furan-BILP) membrane is reported as a photocatalyst for the production of clean H2O2 in pure water. The membrane delivers clean H2O2 solution directly with a high production rate. The strategy of combining molecular engineering and macrostructural engineering may be applied to design other coordination organic polymer photocatalysts with improved performance.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ling Yuan, Chaoqi Zhang, Yingying Zou, Tong Bao, Jing Wang, Cheng Tang, Aijun Du, Chengzhong Yu, Chao Liu
Summary: Constructing MOF-on-MOF heterojunction with elaborate charge transfer and interface can greatly enhance the photocatalytic properties of MOFs. In this study, a Step-scheme (S-scheme) MIL125-NH2@CoFe Prussian blue analogue (PBA) heterojunction was reported for the first time. The designed MOF-on-MOF heterojunction demonstrated significantly enhanced photocatalytic activity for degrading various organic pollutants, which was attributed to the internal electric field and increased active site exposure.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Environmental Sciences
Jun Zhang, Sukitha Kothalawala, Chengzhong Yu
Summary: In the past decade, nanopesticides have been rapidly developed as effective and safe alternatives to conventional pesticides. Various nanotechnologies, such as pesticide nanoemulsions, polymer-based nanopesticides, and metal/metal oxide nanoparticle-based pesticides, have been extensively reviewed. Engineered silica nanomaterials (ESNs) have shown promising potential as carriers in nanopesticides for modern agriculture. However, there is limited research specifically on ESN-based nanopesticides. This comprehensive review provides an introduction to synthetic technology, formation mechanism, and surface engineering technology. The advantages of ESN-based pesticide formulation and their structure-function relationship are discussed in detail. Moreover, the challenges and future research in ESN-based nanopesticide development are also discussed.
ENVIRONMENTAL POLLUTION
(2023)
Article
Chemistry, Applied
Yilun Weng, Supun Ranaweera, Da Zou, Anna P. Cameron, Xiaojing Chen, Hao Song, Chun-Xia Zhao
Summary: Enzymes are essential for industries, but their sensitivity to high temperatures can be problematic. Encapsulation with alginate microparticles has been shown to improve enzyme thermal stability, but other factors like enzyme loading and bioavailability also need to be considered. This study optimized the efficiency of enzyme encapsulation and achieved high enzyme loading and thermal stability, with excellent bioavailability demonstrated in an animal trial.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Multidisciplinary
Chaoqi Zhang, Ling Yuan, Chao Liu, Zimeng Li, Yingying Zou, Xinchan Zhang, Yue Zhang, Zhiqiang Zhang, Guangfeng Wei, Chengzhong Yu
Summary: An elaborate design enables the precise control of Zn/Co bimetallic zeolite imidazole frameworks (ZnCo-ZIFs) and makes them excellent 2e-ORR electrocatalysts. The control at both atomic and nano-scale regulates the role of water molecules and adjusts the coordination unsaturation degree of active sites. The optimized ZnCo-ZIF exhibits high 2e(-) selectivity and H2O2 yield, paving a new avenue for the development of multivariate MOFs as advanced 2e-ORR electrocatalysts.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Applied
Ye Zhang, Zhengying Gu, Wenli Hu, Shumin Li, Yining Yao, Chengzhong Yu
Summary: Bubble-like manganese silicate nanoparticles have attracted much attention due to their wide range of applications, but there is still debate over their formation mechanisms. In this study, we revisit the formation of these nanoparticles and demonstrate a solid-to-hollow conversion process. An intermediate solid MnxOy(CO3)mSiz is formed during the hydrothermal reaction, and its thermal decomposition leads to the transformation from solid to hollow structure. Finally, bubble-like manganese silicate nanoparticles are formed. These findings are expected to provide insights for designing other hollow metal silicate nanoparticles.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Chunhong Xia, Ling Yuan, Hao Song, Chaoqi Zhang, Zimeng Li, Yingying Zou, Jiaxin Li, Tong Bao, Chengzhong Yu, Chao Liu
Summary: Reported here is the spatial specific S-scheme heterojunction design by introducing a novel semiconducting pair with a S-scheme mechanism in a purpose-designed Janus core-shell-structured hollow morphology for photocatalytic oxygen reduction reaction (ORR) and H2O2 production. The TiO2@RF photocatalyst with the spatial specific Janus design shows high H2O2 yield and solar-to-chemical conversion efficiency, surpassing other reported photocatalysts under similar reaction conditions. This work paves the way for the design of next-generation photocatalysts for green synthesis of H2O2 production.
Article
Chemistry, Multidisciplinary
Min Zhang, Yiming Huang, Jie Zou, Yang Yang, Yue Yao, Guofeng Cheng, Yannan Yang
Summary: An advanced oxidation nanoprocessing strategy (AONP) is developed to enhance the immunogenicity of whole tumor cells. AONP utilizes peroxymonosulfate activated by ZIF-67 nanocatalysts to continuously produce SO4- radicals, causing sustained oxidative damage and extensive cell death. AONP-treated whole tumor cells induce immunogenic apoptosis and maintain cellular integrity, maximizing antigen diversity.
Review
Pharmacology & Pharmacy
Bing Sun, Weixi Wu, Eshan A. Narasipura, Yutian Ma, Chengzhong Yu, Owen S. Fenton, Hao Song
Summary: The concept of using mRNA to produce its own medicine in situ in the body holds great potential to revolutionize medicine. The unique characteristics of mRNA call for the design of delivery systems to protect and transport mRNA molecules. This review presents a nanoparticle toolkit for the development of mRNA-based therapeutics, summarizing natural and synthetic nano-delivery systems and discussing strategies for tissue targeting, mRNA release, and boosting mRNA drug activity. Insights into the clinical and translational development of mRNA nano-drugs are also provided.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Dan Cheng, Jun Zhang, Jianye Fu, Hao Song, Chengzhong Yu
Summary: This study presents a hierarchical spatial assembly strategy for fabricating silica-polymer composites and obtaining silica and carbon nanoparticles with unprecedented structures. Through a deeper understanding of the hierarchical spatial assembly mechanism, precise regulation of the structures of nanoparticles is achieved.
Review
Medicine, General & Internal
Pooyan Makvandi, Hao Song, Cynthia K. Y. Yiu, Rossella Sartorius, Ehsan Nazarzadeh Zare, Navid Rabiee, Wei-Xi Wu, Ana Claudia Paiva-Santos, Xiang-Dong Wang, Cheng-Zhong Yu, Franklin R. Tay
Summary: Fungi and bacteria cause numerous pathogen-related infections and diseases in humans. To specifically target and combat these pathogenic species, novel antimicrobials have been developed. This review highlights the cell wall features and antimicrobial mechanisms of these microorganisms, as well as the design of selective antimicrobials. The recent advances in antimicrobial immunomodulation strategy are also discussed.
MILITARY MEDICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Yiru Shi, Zan Dai, Yue Wang, Jiangqi Luo, Larry Cai, Jie Tang, Chengzhong Yu, Yannan Yang
Summary: The study introduces a crystallinity gradient-based selective etching strategy to control the structure and composition of CaO2 nanoparticles. This strategy not only reduces the production of harmful substances and enhances anticancer activity, but also inhibits tumor growth through the lysosome-dependent cell death pathway.
Article
Materials Science, Biomaterials
Mengmeng Zhang, Tianze Wu, Hui Zhang, Zhenxia Chen, Yannan Yang, Yun Ling, Yaming Zhou
Summary: Fe-Gd/CHS exhibits enhanced photothermal properties compared to symmetric Fe-Gd/CS, showing satisfactory MR/PA imaging-guided photothermal therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)