Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms21113965
Keywords
copper coordination compounds; antitumor drug; antibacterial agents; PET imagining agents; mycobacterium tuberculosis; Alzheimer's disease
Funding
- Ministry of Education and Science of the Russian Federation [211]
- Russian Science Foundation [19-74-10059]
- Russian Foundation for Basic Research [19-29-08007]
- Russian Science Foundation [19-74-10059] Funding Source: Russian Science Foundation
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Copper-containing coordination compounds attract wide attention due to the redox activity and biogenicity of copper ions, providing multiple pathways of biological activity. The pharmacological properties of metal complexes can be fine-tuned by varying the nature of the ligand and donor atoms. Copper-containing coordination compounds are effective antitumor agents, constituting a less expensive and safer alternative to classical platinum-containing chemotherapy, and are also effective as antimicrobial, antituberculosis, antimalarial, antifugal, and anti-inflammatory drugs. Cu-64-labeled coordination compounds are promising PET imaging agents for diagnosing malignant pathologies, including head and neck cancer, as well as the hallmark of Alzheimer's disease amyloid-beta (A beta). In this review article, we summarize different strategies for possible use of coordination compounds in the treatment and diagnosis of various diseases, and also various studies of the mechanisms of antitumor and antimicrobial action.
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