Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
Authors
Keywords
-
Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-06-07
DOI
10.1038/s41467-021-23762-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- APOE-amyloid interaction: Therapeutic targets
- (2020) Thomas Wisniewski et al. NEUROBIOLOGY OF DISEASE
- Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice
- (2020) Nicholas F. Fitz et al. Molecular Neurodegeneration
- APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease
- (2020) Aivi T. Nguyen et al. ACTA NEUROPATHOLOGICA
- Microglia and lipids: how metabolism controls brain innate immunity
- (2020) Bruno Chausse et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
- (2019) Carlo Sala Frigerio et al. Cell Reports
- APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain
- (2019) Iliya Lefterov et al. Alzheimers Research & Therapy
- Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice
- (2018) Kyong Nyon Nam et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics
- (2018) Kelly Street et al. BMC GENOMICS
- Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration
- (2018) Aleksandra Deczkowska et al. CELL
- Optogenetic investigation of the variable neurovascular coupling along the interhemispheric circuits
- (2018) Bistra Iordanova et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism
- (2018) Wilbur M. Song et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Integrating single-cell transcriptomic data across different conditions, technologies, and species
- (2018) Andrew Butler et al. NATURE BIOTECHNOLOGY
- Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes
- (2018) Timothy R. Hammond et al. IMMUNITY
- The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives
- (2018) Cody Wolfe et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice
- (2017) Nicholas F. Fitz et al. JOURNAL OF ALZHEIMERS DISEASE
- Microglia in Alzheimer’s disease
- (2017) David V. Hansen et al. JOURNAL OF CELL BIOLOGY
- Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
- (2017) Thais F Galatro et al. NATURE NEUROSCIENCE
- Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer’s model mice
- (2017) Kyong Nyon Nam et al. Scientific Reports
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Lipidomics Analyses Reveal Temporal and Spatial Lipid Organization and Uncover Daily Oscillations in Intracellular Organelles
- (2016) Rona Aviram et al. MOLECULAR CELL
- TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
- (2016) Peng Yuan et al. NEURON
- TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
- (2016) Felix L. Yeh et al. NEURON
- The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function
- (2016) Samuel E. Marsh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
- (2015) Yaming Wang et al. CELL
- Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
- (2015) Yuka Atagi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment
- (2015) Iliya Lefterov et al. NEUROBIOLOGY OF DISEASE
- ATP-binding cassette transporter A1: From metabolism to neurodegeneration
- (2014) Radosveta Koldamova et al. NEUROBIOLOGY OF DISEASE
- ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?
- (2014) Takahisa Kanekiyo et al. NEURON
- Characterization of cardiolipins and their oxidation products by LC–MS analysis
- (2013) Yulia Y. Tyurina et al. CHEMISTRY AND PHYSICS OF LIPIDS
- Phospholipids and Alzheimer’s Disease: Alterations, Mechanisms and Potential Biomarkers
- (2013) Marko Kosicek et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- ApoE influences amyloid- (A ) clearance despite minimal apoE/A association in physiological conditions
- (2013) P. B. Verghese et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice
- (2012) N. F. Fitz et al. JOURNAL OF NEUROSCIENCE
- Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses
- (2011) Xianlin Han et al. MASS SPECTROMETRY REVIEWS
- Apolipoprotein A-I Deficiency Increases Cerebral Amyloid Angiopathy and Cognitive Deficits in APP/PS1ΔE9 Mice
- (2010) Iliya Lefterov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Liver X Receptor Agonist Treatment Ameliorates Amyloid Pathology and Memory Deficits Caused by High-Fat Diet in APP23 Mice
- (2010) N. F. Fitz et al. JOURNAL OF NEUROSCIENCE
- Automated Lipid Identification and Quantification by Multidimensional Mass Spectrometry-Based Shotgun Lipidomics
- (2009) Kui Yang et al. ANALYTICAL CHEMISTRY
- apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
- (2008) Rashid Deane et al. JOURNAL OF CLINICAL INVESTIGATION
- Characterization and properties of preβ-HDL particles formed by ABCA1-mediated cellular lipid efflux to apoA-I
- (2008) Phu T. Duong et al. JOURNAL OF LIPID RESEARCH
- ApoE Promotes the Proteolytic Degradation of Aβ
- (2008) Qingguang Jiang et al. NEURON
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started