Late-Stage Diversification: A Motivating Force in Organic Synthesis
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Title
Late-Stage Diversification: A Motivating Force in Organic Synthesis
Authors
Keywords
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Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 143, Issue 41, Pages 16890-16901
Publisher
American Chemical Society (ACS)
Online
2021-10-07
DOI
10.1021/jacs.1c08920
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Note: Only part of the references are listed.- Enzymatic Late‐Stage Modifications: Better Late than Never
- (2021) Elvira Romero et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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- Erinacine A and related cyathane diterpenoids: Molecular diversity and mechanisms underlying their neuroprotection and anticancer activities
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- (2020) Benke Hong et al. ACS Central Science
- Optically Active Flavaglines-Inspired Molecules by a Palladium-Catalyzed Decarboxylative Dearomative Asymmetric Allylic Alkylation
- (2020) Meng-Yue Cao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Late-Stage Functionalization
- (2020) Jonas Börgel et al. Chem
- Collective Total Synthesis of Casbane Diterpenes: One Strategy, Multiple Targets
- (2020) Alois Fürstner et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- P450 Monooxygenases Enable Rapid Late-Stage Diversification of Natural Products via C−H Bond Activation
- (2019) Nico D. Fessner ChemCatChem
- Synthesis of α‐Quaternary Aldehydes via a Stereoselective Semi‐Pinacol Rearrangement of Optically Active Epoxy Alcohols
- (2019) Naomichi Hirama et al. Asian Journal of Organic Chemistry
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- (2019) Kelly E. Kim et al. TETRAHEDRON
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- (2018) Rashad R. Karimov et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Divergent Strategy in Natural Product Total Synthesis
- (2018) Lei Li et al. CHEMICAL REVIEWS
- Cyanthiwigin Natural Product Core as a Complex Molecular Scaffold for Comparative Late-Stage C–H Functionalization Studies
- (2018) Kelly E. Kim et al. JOURNAL OF ORGANIC CHEMISTRY
- Total Synthesis of (−)-Nodulisporic Acids D, C, and B: Evolution of a Unified Synthetic Strategy
- (2018) Yike Zou et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Stereoselective Total Synthesis of (±)-5-epi-Cyanthiwigin I via an Intramolecular Pauson–Khand Reaction as the Key Step
- (2018) Yuanyuan Chang et al. ORGANIC LETTERS
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- Aliphatic C—H Oxidations for Late-Stage Functionalization
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- (2018) Eric R. Welin et al. SCIENCE
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- (2017) Makoto Yoritate et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Short, Enantioselective Total Synthesis of Highly Oxidized Taxanes
- (2016) Changxia Yuan et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Natural Products as Sources of New Drugs from 1981 to 2014
- (2016) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- Catalytic Anti-Markovnikov Transformations of Hindered Terminal Alkenes Enabled by Aldehyde-Selective Wacker-Type Oxidation
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- (2013) Paul E. Gormisky et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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- (2013) Grant M. Shibuya et al. ORGANIC LETTERS
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- (2013) Ashley M. Adams et al. Chemical Science
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- (2012) Hugo Lachance et al. JOURNAL OF MEDICINAL CHEMISTRY
- Site-Selective Bromination of Vancomycin
- (2012) Tejas P. Pathak et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The generation of “unNatural” products: Synthetic biology meets synthetic chemistry
- (2012) Rebecca J. M. Goss et al. NATURAL PRODUCT REPORTS
- Synthesis of substituted isoquinolines utilizing palladium-catalyzed -arylation of ketones
- (2012) T. J. Donohoe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Total synthesis and cytotoxicity of (−)-jorumycin and its analogues
- (2012) Wei Liu et al. TETRAHEDRON
- Catalytic C–H oxidation by a triazamacrocyclic ruthenium complex
- (2012) Eric McNeill et al. Chemical Science
- Meta-omic Characterization of the Marine Invertebrate Microbial Consortium That Produces the Chemotherapeutic Natural Product ET-743
- (2011) Christopher M. Rath et al. ACS Chemical Biology
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- (2011) Stefan Wetzel et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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- (2011) Duo-Sheng Wang et al. CHEMICAL REVIEWS
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- (2011) Cornelius J. O' Connor et al. CHEMICAL SOCIETY REVIEWS
- Total Syntheses of Cyanthiwigins B, F, and G
- (2011) John A. Enquist et al. CHEMISTRY-A EUROPEAN JOURNAL
- Transformation products of pharmaceuticals in surface waters and wastewater formed during photolysis and advanced oxidation processes – Degradation, elucidation of byproducts and assessment of their biological potency
- (2011) D. Fatta-Kassinos et al. CHEMOSPHERE
- Collective synthesis of natural products by means of organocascade catalysis
- (2011) Spencer B. Jones et al. NATURE
- Scalable enantioselective total synthesis of taxanes
- (2011) Abraham Mendoza et al. Nature Chemistry
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- (2010) Alison N. Campbell et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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- (2010) Samuel Danishefsky NATURAL PRODUCT REPORTS
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- (2010) Aaron L. Nelson et al. NATURE REVIEWS DRUG DISCOVERY
- Combined Effects on Selectivity in Fe-Catalyzed Methylene Oxidation
- (2010) M. S. Chen et al. SCIENCE
- Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules
- (2010) Warren R.J.D. Galloway et al. Nature Communications
- An Approach to the Site-Selective Diversification of Apoptolidin A with Peptide-Based Catalysts
- (2009) Chad A. Lewis et al. JOURNAL OF NATURAL PRODUCTS
- Synthetic efforts toward cyathane diterpenoid natural products
- (2009) John A. Enquist et al. NATURAL PRODUCT REPORTS
- Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem
- (2009) Carmen Cuevas et al. NATURAL PRODUCT REPORTS
- Total synthesis of eudesmane terpenes by site-selective C–H oxidations
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- (2009) Yan-Chao Wu et al. ORGANIC LETTERS
- Catalytic site-selective synthesis and evaluation of a series of erythromycin analogs
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- (2008) M. Kaiser et al. CELLULAR AND MOLECULAR LIFE SCIENCES
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- Site-Selective sp2and Benzylic sp3Palladium-Catalyzed Direct Arylation
- (2008) Louis-Charles Campeau et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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- (2008) Mark S. Butler NATURAL PRODUCT REPORTS
- The total synthesis of (-)-cyanthiwigin F by means of double catalytic enantioselective alkylation
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- Conversion of cyanthiwigin U to related cyanthiwigins: total syntheses of cyanthiwigin W and cyanthiwigin Z
- (2008) Matthew W.B. Pfeiffer et al. TETRAHEDRON LETTERS
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- (2007) Paul A. Wender et al. ACCOUNTS OF CHEMICAL RESEARCH
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