Biology-Oriented Synthesis

Bioactivity-Guided Navigation of Chemical Space

(2010) Robin S. Bon et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

(2010) Stefan Wetzel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

(2010) Oliver Rocks et al.   CELL

Silver catalyzed cascade synthesis of alkaloid ring systems: concise total synthesis of fascaplysin, homofascaplysin C and analogues

(2010) Herbert Waldmann et al.   CHEMICAL COMMUNICATIONS

Enhancements of screening collections to address areas of unmet medical need: an industry perspective

(2010) David H Drewry et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Synthesis and Structure−Activity Correlation of Natural-Product Inspired Cyclodepsipeptides Stabilizing F-Actin

(2010) René Tannert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

The art of the chemical probe

(2010) Stephen V Frye   Nature Chemical Biology

Structure-based discovery of antibacterial drugs

(2010) Katie J. Simmons et al.   NATURE REVIEWS MICROBIOLOGY

The Ras Pathway Modulator Melophlin A Targets Dynamins

(2009) Tanja Knoth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Natural Product Inspired Compound Collections

(2009) Kamal Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Principles, implementation, and application of biology-oriented synthesis (BIOS)

(2009) Wolfram Wilk et al.   BIOLOGICAL CHEMISTRY

Synthesis and Structure-Activity Correlation of a Brunsvicamide-Inspired Cyclopeptide Collection

(2009) Thilo Walther  et al.   CHEMBIOCHEM

Advances in Solution- and Solid-Phase Synthesis toward the Generation of Natural Product-like Libraries

(2009) Jyoti P. Nandy et al.   CHEMICAL REVIEWS

From Machine Learning to Natural Product Derivatives that Selectively Activate Transcription Factor PPARγ

(2009) Matthias Rupp et al.   ChemMedChem

The therapeutic potential of phosphatase inhibitors

(2009) Viktor V Vintonyak et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Novel Chemical Space Exploration via Natural Products

(2009) Josefin Rosén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioactivity-guided mapping and navigation of chemical space

(2009) Steffen Renner et al.   Nature Chemical Biology

Erratum: Corrigendum: Interactive exploration of chemical space with Scaffold Hunter

(2009) Stefan Wetzel et al.   Nature Chemical Biology

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Discovery of a New Class of Inhibitors ofMycobacterium tuberculosisProtein Tyrosine Phosphatase B by Biology-Oriented Synthesis

(2008) Andrea Nören-Müller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric Synthesis of Natural Product Inspired Tricyclic Benzopyrones by an Organocatalyzed Annulation Reaction

(2008) Herbert Waldmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Total Synthesis of Chondramide C and Its Binding Mode to F-Actin

(2008) Herbert Waldmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biology-inspired synthesis of compound libraries

(2008) M. Kaiser et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Signal Transducers and Activators of Transcription as Targets for Small Organic Molecules

(2008) Thorsten Berg   CHEMBIOCHEM

Scaffold diversity of natural products: inspiration for combinatorial library design

(2008) Kristina Grabowski et al.   NATURAL PRODUCT REPORTS

Reverse engineering intracellular biochemical networks

(2008) Eli Zamir et al.   Nature Chemical Biology

Rapid generation of macrocycles with natural-product-like side chains by multiple multicomponent macrocyclizations (MiBs)

(2008) Daniel G. Rivera et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Solid-Support Based Total Synthesis and Stereochemical Correction of Brunsvicamide A

(2008) Thilo Walther et al.   ORGANIC LETTERS

Synthesis of a dysidiolide-inspired compound library and discovery of acetylcholinesterase inhibitors based on protein structure similarity clustering (PSSC)

(2008) Michael Scheck et al.   TETRAHEDRON