Journal
JOURNAL OF NATURAL PRODUCTS
Volume 76, Issue 9, Pages 1789-1795Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np400538q
Keywords
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Funding
- National Natural Science Foundation of China [20802045, 21172153]
- National Basic Research Program of China (973 Program) [2012CB833200]
- Foundation of the Education Ministry of China for Returnees
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Three renieramycin-type antitumor alkaloids, (-)-jorunnamycins A (1) and C (2) and (-)-jorumycin (3), have been synthesized by a new convergent approach, which features a highly regio- and stereoselective Pictet-Spengler cydization to couple the isoquinoline and the trisubstituted phenylalaninol partners. This synthetic strategy opens an economical access to these important antitumor alkaloids with high yields: (-)-jorunnamycin A, as a common precursor to other renieramycin-type alkaloids and their analogues, is obtained with 18.1% overall yield from L-tyrosine.
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